The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways (Q36425893)

14 August 2017

The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways (English)

1 reference

14 August 2017

Olivier Boucherat

1

1 reference

PMCID

3507293

14 August 2017

Jamila Chakir

series ordinal

2

1 reference

PMCID

3507293

14 August 2017

Lucie Jeannotte

series ordinal

3

1 reference

14 August 2017

29 May 2012

1 reference

14 August 2017

1 reference

14 August 2017

1

1 reference

14 August 2017

7

1 reference

14 August 2017

677-691

1 reference

Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported

14 August 2017

start time

2 September 2020

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The loss of Hoxa5 function causes estrous acyclicity and ovarian epithelial inclusion cysts

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Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.

30 September 2017

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Generation and characterization of a Cyp2f2-null mouse and studies on the role of CYP2F2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa

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Notch-dependent differentiation of adult airway basal stem cells

30 September 2017

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Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation

30 September 2017

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Airway mucus function and dysfunction

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The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema.

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Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium

30 September 2017

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Multiple promoters and alternative splicing: Hoxa5 transcriptional complexity in the mouse embryo

30 September 2017

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Preparing for the first breath: genetic and cellular mechanisms in lung development

30 September 2017

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Signaling via Alk5 controls the ontogeny of lung Clara cells.

30 September 2017

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Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate

30 September 2017

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SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production

30 September 2017

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Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut

30 September 2017

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Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.

30 September 2017

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Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

30 September 2017

1 reference

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The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium

30 September 2017

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Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung

30 September 2017

1 reference

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SERKAL syndrome: an autosomal-recessive disorder caused by a loss-of-function mutation in WNT4

30 September 2017

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Gene expression profiling in lung fibroblasts reveals new players in alveolarization

30 September 2017

1 reference

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SPDEF regulates goblet cell hyperplasia in the airway epithelium

30 September 2017

1 reference

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GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo

30 September 2017

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Impact of the loss of Hoxa5 function on lung alveogenesis

30 September 2017

1 reference

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Stromal Hoxa5 function controls the growth and differentiation of mammary alveolar epithelium

30 September 2017

1 reference

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Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Beta-catenin regulates differentiation of respiratory epithelial cells in vivo

30 September 2017

1 reference

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Beta-catenin signaling marks the prospective site of primitive streak formation in the mouse embryo

30 September 2017

1 reference

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Functional diversity of notch family genes in fetal lung development

30 September 2017

1 reference

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Wnt5a participates in distal lung morphogenesis

30 September 2017

1 reference

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Role of gob-5 in mucus overproduction and airway hyperresponsiveness in asthma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Mice mutant for both Hoxa1 and Hoxb1 show extensive remodeling of the hindbrain and defects in craniofacial development

30 September 2017

1 reference

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Application of lacZ transgenic mice to cell lineage studies

30 September 2017

1 reference

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Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

30 September 2017

1 reference

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Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Early postnatal lethality in Hoxa-5 mutant mice is attributable to respiratory tract defects

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Defective development of the embryonic liver in N-myc-deficient mice.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Homeobox genes from clusters A and B demonstrate characteristics of temporal colinearity and differential restrictions in spatial expression domains in the branching mouse lung.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Canonical Wnt signaling negatively regulates branching morphogenesis of the lung and lacrimal gland.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Mucin is produced by clara cells in the proximal airways of antigen-challenged mice

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Contribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Foxa2 regulates alveolarization and goblet cell hyperplasia.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Mesenchyme specifies epithelial differentiation in reciprocal recombinants of embryonic lung and trachea.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Cellular response in naphthalene-induced Clara cell injury and bronchiolar epithelial repair in mice

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Analysis of beta 2-microglobulin gene expression in the developing mouse embryo and placenta.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3507293

Stomach regional specification requires Hoxa5-driven mesenchymal-epithelial signaling

21 September 2018

1 reference

12 December 2020

Identification of Hox genes in newborn lung and effects of gestational age and retinoic acid on their expression

1 reference

12 December 2020

Ectopic respiratory epithelial cell differentiation in bronchiolised distal airspaces in idiopathic pulmonary fibrosis

1 reference

12 December 2020

Induction in vitro of tracheal buds by pulmonary mesenchyme grafted on tracheal epithelium

1 reference

12 December 2020

Foxa2 programs Th2 cell-mediated innate immunity in the developing lung

1 reference

12 December 2020

Identifiers

DOI

10.1242/BIO.20121701

1 reference

14 August 2017

1 reference

14 August 2017

1 reference

PMCID

3507293