Inhibition of RANKL as a treatment for osteoporosis: preclinical and early clinical studies (Q36417317)

14 August 2017

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title

Inhibition of RANKL as a treatment for osteoporosis: preclinical and early clinical studies (English)

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14 August 2017

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1

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14 August 2017

publication date

1 March 2006

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Current osteoporosis reports

14 August 2017

published in

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14 August 2017

volume

4

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14 August 2017

issue

1

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14 August 2017

page(s)

28-33

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https://scigraph.springernature.com/pub.10.1007/s11914-006-0012-7

14 August 2017

exact match

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cites work

Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo

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https://api.crossref.org/works/10.1007%2FS11914-006-0012-7

Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11914-006-0012-7

Direct inhibition of NF-kappa B blocks bone erosion associated with inflammatory arthritis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11914-006-0012-7

Raloxifene concurrently stimulates osteoprotegerin and inhibits interleukin-6 production by human trabecular osteoblasts

21 January 2018

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12 December 2020

A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases

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12 December 2020

Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines

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12 December 2020

Bone resorption by osteoclasts

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12 December 2020

TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor

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12 December 2020

Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis

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12 December 2020

Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2.

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12 December 2020

OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats

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12 December 2020

Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization

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12 December 2020

Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells

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12 December 2020

A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1beta, TNF-alpha, PTH, PTHrP, and 1, 25(OH)2D3.

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12 December 2020

The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis

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12 December 2020

PTH differentially regulates expression of RANKL and OPG.

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12 December 2020

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density

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12 December 2020

The effect of a single dose of osteoprotegerin in postmenopausal women

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12 December 2020

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

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12 December 2020

Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone

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12 December 2020

Regulation of the differentiation and function of osteoclasts

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12 December 2020

Interleukin-1beta and tumor necrosis factor-alpha, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

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12 December 2020

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

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12 December 2020

Bone marrow metastatic myeloma cells promote osteoclastogenesis through RANKL on endothelial cells

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12 December 2020

Osteoprotegerin administration reduces femural bone loss in ovariectomized mice via impairment of osteoclast structure and function

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12 December 2020

Estrogen stimulates gene expression and protein production of osteoprotegerin in human osteoblastic cells

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12 December 2020

Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis

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12 December 2020

Parathyroid hormone receptor in intact embryonic chicken bone: characterization and cellular localization

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12 December 2020

A mutation in the gene TNFRSF11B encoding osteoprotegerin causes an idiopathic hyperphosphatasia phenotype

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12 December 2020

The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy.

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12 December 2020

A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women

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12 December 2020

Evidence of estrogen receptors in normal human osteoblast-like cells

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12 December 2020

Osteoprotegerin mitigates tail suspension-induced osteopenia

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12 December 2020

Osteoprotegerin deficiency and juvenile Paget's disease.

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12 December 2020

Adenoviral delivery of osteoprotegerin ameliorates bone resorption in a mouse ovariectomy model of osteoporosis

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12 December 2020

Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis

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12 December 2020

Osteoblastic cells are involved in osteoclast formation.

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12 December 2020

CORRELATION OF BONE RESORPTION AND FORMATION WITH THE PHYSICAL BEHAVIOR OF LOADED BONE

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12 December 2020

Identification of a novel tandem duplication in exon 1 of the TNFRSF11A gene in two unrelated patients with familial expansile osteolysis.

1 reference

12 December 2020

Expansile skeletal hyperphosphatasia is caused by a 15-base pair tandem duplication in TNFRSF11A encoding RANK and is allelic to familial expansile osteolysis

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12 December 2020

Proposed standard nomenclature for new tumor necrosis factor family members involved in the regulation of bone resorption. The American Society for Bone and Mineral Research President's Committee on Nomenclature

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12 December 2020

Increased osteoclast development after estrogen loss: mediation by interleukin-6

1 reference

12 December 2020

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1 reference

12 December 2020

Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy.

1 reference

12 December 2020

10.1007/S11914-006-0012-7

Identifiers

DOI

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14 August 2017

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