Rescue of pituitary function in a mouse model of isolated growth hormone deficiency type II by RNA interference (Q36415876)

14 August 2017

Rescue of pituitary function in a mouse model of isolated growth hormone deficiency type II by RNA interference (English)

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isolated growth hormone deficiency type II

14 August 2017

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Nikki Shariat

1

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14 August 2017

Robin C C Ryther

2

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14 August 2017

John A Phillips

3

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14 August 2017

Iain C A F Robinson

4

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14 August 2017

James G Patton

5

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14 August 2017

language of work or name

English

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publication date

15 November 2007

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14 August 2017

7

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inferred from page(s)

published in

Endocrinology

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14 August 2017

149

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14 August 2017

2

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14 August 2017

580-586

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describes a project that uses

14 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2219309/fullTextXML

inferred from PubMed Central ID database lookup

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Genetics of growth hormone deficiency

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GH1 splicing is regulated by multiple enhancers whose mutation produces a dominant-negative GH isoform that can be degraded by allele-specific small interfering RNA (siRNA).

30 September 2017

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Autosomal dominant growth hormone deficiency disrupts secretory vesicles in vitro and in vivo in transgenic mice.

30 September 2017

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Autosomal dominant GH deficiency due to an Arg183His GH-1 gene mutation: clinical and molecular evidence of impaired regulated GH secretion

30 September 2017

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Autosomal dominant growth hormone (GH) deficiency type II: the Del32-71-GH deletion mutant suppresses secretion of wild-type GH.

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Variability of isolated autosomal dominant GH deficiency (IGHD II): impact of the P89L GH mutation on clinical follow-up and GH secretion

21 September 2018

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Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

21 September 2018

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Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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Disruption of exon definition produces a dominant-negative growth hormone isoform that causes somatotroph death and IGHD II

21 September 2018

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Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short stature

21 September 2018

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The molecular genetics of growth hormone deficiency

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18006625

12 December 2020

inferred from PubMed ID database lookup

Inhibition of growth hormone (GH) secretion by a mutant GH-I gene product in neuroendocrine cells containing secretory granules: an implication for isolated GH deficiency inherited in an autosomal dominant manner

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18006625

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1210/EN.2007-1360

1 reference

14 August 2017

1 reference

14 August 2017

PubMed publication ID

18006625

1 reference