Biochemistry and clinical role of trypsinogens and pancreatic secretory trypsin inhibitor (Q36414170)

14 August 2017

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title

Biochemistry and clinical role of trypsinogens and pancreatic secretory trypsin inhibitor (English)

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14 August 2017

2

Ulf-Håkan Stenman

1 reference

14 August 2017

Annukka Paju

1

1 reference

14 August 2017

1 January 2006

1 reference

Critical Reviews in Clinical Laboratory Sciences

14 August 2017

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14 August 2017

43

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14 August 2017

103-142

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14 August 2017

2

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ISOLATION FROM BEEF PANCREAS OF CRYSTALLINE TRYPSINOGEN, TRYPSIN, A TRYPSIN INHIBITOR, AND AN INHIBITOR-TRYPSIN COMPOUND

14 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Trypsinogen variants in pancreatic juice of healthy volunteers, chronic alcoholics, and patients with pancreatitis and cancer of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Cloning of the cDNA encoding human brain trypsinogen and characterization of its product

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Activation of type IV procollagenases by human tumor-associated trypsin-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

The complete 685-kilobase DNA sequence of the human beta T cell receptor locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Genes, cloned cDNAs, and proteins of human trypsinogens and pancreatitis-associated cationic trypsinogen mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Identification of a cell-specific DNA-binding activity that interacts with a transcriptional activator of genes expressed in the acinar pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

A pancreatic exocrine cell factor and AP4 bind overlapping sites in the amylase 2A enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Two human trypsinogens. Purification, molecular properties, and N-terminal sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Cloning, characterization and nucleotide sequences of two cDNAs encoding human pancreatic trypsinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Immunofluorescent localisation of enterokinase in human small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Expression of enteropeptidase in differentiated enterocytes, goblet cells, and the tumor cells in human duodenum

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Presence of cathepsin B in the human pancreatic secretory pathway and its role in trypsinogen activation during hereditary pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Human Mesotrypsin Is a Unique Digestive Protease Specialized for the Degradation of Trypsin Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Enhancement of the autocatalytic activation of trypsinogen to trypsin by bile and bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Human anionic trypsinogen: properties of autocatalytic activation and degradation and implications in pancreatic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Isolation of a crystalline trypsin inhibitor-anticoagulant protein from pancreas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Cultured human monocytes synthesize and secrete alpha2-macroglobulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Inhibition of plasmin activity by alpha-2-macroglobulin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Structure and variation of human alpha 1-antitrypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Crystal structures of rat anionic trypsin complexed with the protein inhibitors APPI and BPTI

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Pancreatic endoproteases and pancreatic secretory trypsin inhibitor immunoreactivity in human Paneth cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Paneth cell trypsin is the processing enzyme for human defensin-5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Expression of trypsin by epithelial cells of various tissues, leukocytes, and neurons in human and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Expression and characterization of trypsinogen produced in the human male genital tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Trypsin IV, a novel agonist of protease-activated receptors 2 and 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Human trypsinogen in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Trypsinogen expression in human ovarian carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Pancreatic trypsinogen and cathepsin B in human pancreatic carcinomas and associated metastatic lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

S100 family members and trypsinogens are predictors of distant metastasis and survival in early-stage non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Borderline ovarian tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Expression of trypsinogen-1, trypsinogen-2, and tumor-associated trypsin inhibitor in ovarian cancer: prognostic study on tissue and serum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Expression of tumor-associated trypsinogens (TAT-1 and TAT-2) in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Characterization of trypsinogens 1 and 2 in two human pancreatic adenocarcinoma cell lines; CFPAC-1 and CAPAN-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Identification of one- and two-chain forms of trypsinogen 1 produced by a human gastric adenocarcinoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Stimulation of cellular growth and adhesion to fibronectin and vitronectin in culture and tumorigenicity in nude mice by overexpression of trypsinogen in human gastric cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Production of trypsins by human gastric cancer cells correlates with their malignant phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Matrix metalloproteinases: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Tumor-Associated Trypsinogen-2 (Trypsinogen-2) Activates Procollagenases (MMP-1, -8, -13) and Stromelysin-1 (MMP-3) and Degrades Type I Collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

The urokinase-type plasminogen activator system in cancer metastasis: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Enhanced invasiveness of pancreatic adenocarcinoma cells stably transfected with cationic trypsinogen cDNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

MMP-9 activation by tumor trypsin-2 enhances in vivo invasion of human tongue carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Radioimmunological determination and characterization of cathodal trypsin-like immunoreactivity in normal human plasma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Demonstration of human pancreatic anionic trypsinogen in normal serum by radioimmunoassay

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Human fibroblast collagenase: glycosylation and tissue-specific levels of enzyme synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Partial purification and characterization of a neutral protease which cleaves type IV collagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Human matrix metalloproteinase-9: activation by limited trypsin treatment and generation of monoclonal antibodies specific for the activated form.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Characterization of the precursor of prostate-specific antigen. Activation by trypsin and by human glandular kallikrein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Complex formation between protein C inhibitor and prostate-specific antigen in vitro and in human semen

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

A kallikrein-like serine protease in prostatic fluid cleaves the predominant seminal vesicle protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Human prostate-specific antigen: structural and functional similarity with serine proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Enzymatic activity of prostate-specific antigen and its reactions with extracellular serine proteinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Activation of the zymogen form of prostate-specific antigen by human glandular kallikrein 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Extrapancreatic trypsin-2 cleaves proteinase-activated receptor-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Molecular cloning and functional expression of the gene encoding the human proteinase-activated receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Trypsin is produced by and activates protease-activated receptor-2 in human cancer colon cells: evidence for new autocrine loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Protease-activated receptor-2 regulates cell proliferation and enhances cyclooxygenase-2 mRNA expression in human pancreatic cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Endogenous vertebrate antibiotics. Defensins, protegrins, and other cysteine-rich antimicrobial peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Hereditary pancreatitis: new insights into acute and chronic pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Pathogenesis of acute pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Expression of mutated cationic trypsinogen reduces cellular viability in AR4-2J cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Diagnostic importance of changes in circulating concentrations of immunoreactive trypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Do trypsin 2-alpha-1-antitrypsin complexes occur naturally in the circulation?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Immunoreactive anionic and cationic trypsin in human serum

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Serum complex of trypsin 2 and alpha 1 antitrypsin as diagnostic and prognostic marker of acute pancreatitis: clinical study in consecutive patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Urinary trypsinogen-2 test strip for acute pancreatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Increased serum trypsinogen 2 and trypsin 2-alpha 1 antitrypsin complex values identify endoscopic retrograde cholangiopancreatography induced pancreatitis with high accuracy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Dried-blood spot screening for cystic fibrosis in the newborn

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Newborn screening methods for cystic fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Association of trypsin expression with recurrence and poor prognosis in human esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

The levels of trypsinogen isoenzymes in ovarian tumour cyst fluids are associated with promatrix metalloproteinase-9 but not promatrix metalloproteinase-2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Identification of novel pancreas-specific regulatory sequences in the promoter region of human pancreatic secretory trypsin inhibitor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Identification of the IL-6-responsive element in an acute-phase-responsive human pancreatic secretory trypsin inhibitor-encoding gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Site-directed mutagenesis of human pancreatic secretory trypsin inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Pancreatic secretory trypsin inhibitor in gastrointestinal mucosa and gastric juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Gastric output of pancreatic secretory trypsin inhibitor is increased by misoprostol

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Role of acrosomal matrix proteases in sperm-zona pellucida interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Epidermal growth factor: internal duplication and probable relationship to pancreatic secretory trypsin inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Identification and characterization of receptors specific for human pancreatic secretory trypsin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Pancreatic secretory trypsin inhibitor stimulates the growth of rat pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Initial characterization of aldehyde dehydrogenase from rat testis cytosol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Immunohistochemical demonstration of pancreatic secretory trypsin inhibitor in normal and neoplastic colonic mucosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Expression of pancreatic secretory trypsin inhibitor (PSTI) in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Identification of genes up-regulated in urothelial tumors: the 67-kd laminin receptor and tumor-associated trypsin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Mutations in the SPINK1 gene in idiopathic pancreatitis Italian patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Mutation in the SPINK1 trypsin inhibitor gene, alcohol use, and chronic pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Mutations N34S and P55S of the SPINK1 gene in patients with chronic pancreatitis or pancreatic cancer and in healthy subjects: a report from Finland

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Serine protease inhibitor kazal type 1 mutations and pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Two novel severe mutations in the pancreatic secretory trypsin inhibitor gene (SPINK1) cause familial and/or hereditary pancreatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Tumour-associated trypsin inhibitor, TATI, in patients with pancreatic cancer, pancreatitis and benign biliary diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Tumour-associated trypsin inhibitor (TATI): comparison with CA125 as a preoperative prognostic indicator in advanced ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Urinary levels of tumor-associated trypsin inhibitor (TATI) in the detection of transitional cell carcinoma of the urinary bladder

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Serum tumour markers CA 15-3, TPA, TPS, hCGbeta and TATI in the monitoring of chemotherapy response in metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

The primary structure of the human pancreatic secretory trypsin inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Secretion of alpha-2-macroglobulin by human alveolar macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

Cell-specific expression controlled by the 5′-flanking region of insulin and chymotrypsin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10408360500523852

10.1080/10408360500523852

21 January 2018

Identifiers

DOI

1 reference

release_mhm3znzw4bdcfl27zjm6f2pvxq

14 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mhm3znzw4bdcfl27zjm6f2pvxq

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

16517420

1 reference

PubMed ID

16517420