Immune systems in developed and developing countries; implications for the design of vaccines that will work where BCG does not. (Q36410721)

14 August 2017

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title

Immune systems in developed and developing countries; implications for the design of vaccines that will work where BCG does not. (English)

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14 August 2017

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3

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14 August 2017

2

Keertan Dheda

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14 August 2017

Graham A W Rook

1

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14 August 2017

28 February 2006

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14 August 2017

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14 August 2017

86

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14 August 2017

3-4

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14 August 2017

152-162

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Geographic latitude and the efficacy of bacillus Calmette-Guérin vaccine

14 August 2017

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature

7 January 2021

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Variation in protection by BCG: implications of and for heterologous immunity

7 January 2021

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Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC).

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

The rise of childhood type 1 diabetes in the 20th century.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Increasing incidence of multiple sclerosis in South Lower Saxony, Germany

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

The effect of infections on susceptibility to autoimmune and allergic diseases

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Prospective survey of childhood inflammatory bowel disease in the British Isles

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Inflammatory bowel disease in children and adolescents in Sweden, 1984-1995.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Relation between occurrence of type 1 diabetes and asthma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Reduced transforming growth factor-beta1-producing T cells in the duodenal mucosa of children with food allergy

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

CD4+CD25bright T cells in human intestinal lamina propria as regulatory cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Failure to induce oral tolerance to a soluble protein in patients with inflammatory bowel disease

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Allergy, parasites, and the hygiene hypothesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Mycobacterium vaccae induces a population of pulmonary CD11c+ cells with regulatory potential in allergic mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Microbes, immunoregulation, and the gut.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Trichuris suis therapy in Crohn's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Immunological and pathological comparative analysis between experimental latent tuberculous infection and progressive pulmonary tuberculosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Immunotherapy with plasmid DNA encoding mycobacterial hsp65 in association with chemotherapy is a more rapid and efficient form of treatment for tuberculosis in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Persistence of DNA from Mycobacterium tuberculosis in superficially normal lung tissue during latent infection

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Lung remodeling in pulmonary tuberculosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1).

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Type 2 Cytokine Gene Activation and Its Relationship to Extent of Disease in Patients with Tuberculosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Pulmonary tuberculosis in BALB/c mice with non-functional IL-4 genes: changes in the inflammatory effects of TNF-alpha and in the regulation of fibrosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Contribution of Th1 and Th2 cells to protection and pathology in experimental models of granulomatous lung disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

IL-4-regulated enteropathy in an intestinal nematode infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Absence of interleukin-4 determines less severe pulmonary paracoccidioidomycosis associated with impaired Th2 response

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Mice incapable of making IL-4 or IL-10 display normal resistance to infection with Mycobacterium tuberculosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

IL-4 in tuberculosis: implications for vaccine design

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Environmental mycobacteria in northern Malawi: implications for the epidemiology of tuberculosis and leprosy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Prospects for low dose BCG vaccination against tuberculosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Do successful tuberculosis vaccines need to be immunoregulatory rather than merely Th1-boosting?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Validation of housekeeping genes for normalizing RNA expression in real-time PCR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

In vivo and in vitro studies of a novel cytokine, interleukin 4delta2, in pulmonary tuberculosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Structural and functional properties of IL-4delta2, an alternative splice variant of human IL-4.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Cloning of interleukin-4 delta2 splice variant (IL-4delta2) in chimpanzee and cynomolgus macaque: phylogenetic analysis of delta2 splice variant appearance, and implications for the study of IL-4-driven immune processes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Alternative Splicing of Murine Interleukin-4 mRNA

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Interleukin-4 and Its Alternatively Spliced Variant (IL-4 δ 2) in Patients with Atopic Asthma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Increased expression of mRNA encoding interleukin (IL)-4 and its splice variant IL-4delta2 in cells from contacts of Mycobacterium tuberculosis, in the absence of in vitro stimulation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4delta2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Alternative activation of macrophages

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

THP-1 cell apoptosis in response to Mycobacterial infection

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

TNF-dependent BALB/c murine macrophage apoptosis following Mycobacterium tuberculosis infection inhibits bacillary growth in an IFN-gamma independent manner

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

IL-4, IL-10 and IFN-gamma have distinct, but interacting, effects on differentiation-induced changes in TNF-alpha and TNF receptor release by cultured human monocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Effects of interleukin 4 on CD25+CD4+ regulatory T cell function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Increased Interleukin-4 production by CD8 and gammadelta T cells in health-care workers is associated with the subsequent development of active tuberculosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Regulatory T cells and mechanisms of immune system control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Induction of T helper type 1-like regulatory cells that express Foxp3 and protect against airway hyper-reactivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Autoreactive human peripheral blood CD8+ T cells with a regulatory phenotype and function.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Antigen-specific and persistent tuberculin anergy in a cohort of pulmonary tuberculosis patients from rural Cambodia

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

IL-10-producing T cells suppress immune responses in anergic tuberculosis patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Detection of low-frequency antigen-specific IL-10-producing CD4(+) T cells via ELISPOT in PBMC: cognate vs. nonspecific production of the cytokine

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

TNF-alpha, TGF-beta and NO relationship in sera from tuberculosis (TB) patients of different severity

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

The role of TGF beta in the pathogenesis of human tuberculosis.

7 January 2021

1 reference

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CD4+ T Cell Clones Producing both Interferon-γ and Interleukin-10 Predominate in Bronchoalveolar Lavages of Active Pulmonary Tuberculosis Patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Enhanced responses to Mycobacterium tuberculosis antigens by human alveolar lymphocytes during active pulmonary tuberculosis

7 January 2021

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T lymphocyte phenotypic profile in lung segments affected by cavitary and non-cavitary tuberculosis.

7 January 2021

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The success and failure of BCG - implications for a novel tuberculosis vaccine

7 January 2021

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Annulling a dangerous liaison: vaccination strategies against AIDS and tuberculosis

7 January 2021

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Immune responses to mycobacterial antigens in the Gambian population: implications for vaccines and immunodiagnostic test design

7 January 2021

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Gamma interferon responses induced by a panel of recombinant and purified mycobacterial antigens in healthy, non-mycobacterium bovis BCG-vaccinated Malawian young adults

7 January 2021

1 reference

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Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara

7 January 2021

1 reference

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Improved immunogenicity and protective efficacy of a tuberculosis DNA vaccine encoding Ag85 by protein boosting

7 January 2021

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Failure to induce enhanced protection against tuberculosis by increasing T-cell-dependent interferon-gamma generation

7 January 2021

1 reference

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A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosis

7 January 2021

1 reference

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Mycobacterium bovis BCG producing interleukin-18 increases antigen-specific gamma interferon production in mice.

7 January 2021

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Immune responses to tuberculosis in developing countries: implications for new vaccines

7 January 2021

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BCG vaccination: A comparison of post-vaccination tuberculin sensitivity after oral and intradermal vaccination of newborn infants

7 January 2021

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Mucosal bacille calmette-Guérin vaccination of humans inhibits delayed-type hypersensitivity to purified protein derivative but induces mycobacteria-specific interferon-gamma responses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Oral vaccination with subunit vaccines protects animals against aerosol infection with Mycobacterium tuberculosis

7 January 2021

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BCG-induced protection in guinea pigs vaccinated and challenged via the respiratory route

7 January 2021

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Intranasal vaccination of mice against infection with Mycobacterium tuberculosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Single intranasal mucosal Mycobacterium bovis BCG vaccination confers improved protection compared to subcutaneous vaccination against pulmonary tuberculosis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Mechanisms of mucosal and parenteral tuberculosis vaccinations: adenoviral-based mucosal immunization preferentially elicits sustained accumulation of immune protective CD4 and CD8 T cells within the airway lumen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Nasal boost with adjuvanted heat-killed BCG or arabinomannan–protein conjugate improves primary BCG-induced protection in C57BL/6 mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Intranasal bacille Calmette-Guerin (BCG) vaccine dosage needs balancing between protection and lung pathology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

Effect of in vitro infection of human monocytes with low numbers of Mycobacterium tuberculosis bacteria on monocyte apoptosis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TUBE.2006.01.018

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7 January 2021

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Identifiers

DOI

10.1016/J.TUBE.2006.01.018

1 reference

14 August 2017

1 reference

PubMed ID

16510309