Protein arginine deiminase 4: evidence for a reverse protonation mechanism (Q36402001)

14 August 2017

Protein arginine deiminase 4: evidence for a reverse protonation mechanism (English)

1 reference

14 August 2017

Bryan Knuckley

1

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author name string

Monica Bhatia

series ordinal

2

1 reference

PMCID

2212595

14 August 2017

Paul R Thompson

series ordinal

3

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PMCID

2212595

14 August 2017

language of work or name

English

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publication date

12 May 2007

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14 August 2017

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14 August 2017

46

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14 August 2017

6578-6587

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14 August 2017

22

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Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock?

14 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

The role of citrullinated proteins suggests a novel mechanism in the pathogenesis of multiple sclerosis

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Methylation of the guanidino group of arginine residues prevents citrullination by peptidylarginine deiminase IV.

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Human PAD4 regulates histone arginine methylation levels via demethylimination

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Histone deimination antagonizes arginine methylation

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Structural basis for Ca(2+)-induced activation of human PAD4

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Citrullinated proteins: sparks that may ignite the fire in rheumatoid arthritis

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Newer approaches to the treatment of rheumatoid arthritis.

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Structural insight into arginine degradation by arginine deiminase, an antibacterial and parasite drug target

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Therapeutic strategies for rheumatoid arthritis

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Nuclear localization of peptidylarginine deiminase V and histone deimination in granulocytes

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Molecular mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: roles of conserved active site residues

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

ABC of rheumatology. Rheumatoid arthritis--I: Clinical features and diagnosis

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

2 references

30 September 2017

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Deuterium Isotope Effects on Papain Acylation. Evidence for Lack of General Base Catalysis and for Enzyme-Leaving-Group Interaction

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

28 June 2018

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

28 June 2018

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

A novel superfamily of enzymes that catalyze the modification of guanidino groups.

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Active site labeling of the Yersinia protein tyrosine phosphatase: the determination of the pKa of the active site cysteine and the function of the conserved histidine 402.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Mercaptide-imidazolium ion-pair: the reactive nucleophile in papain catalysis

28 June 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

28 June 2018

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Overexpression of peptidylarginine deiminase IV features in apoptosis of haematopoietic cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Kinetic analysis of Pseudomonas aeruginosa arginine deiminase mutants and alternate substrates provides insight into structural determinants of function.

21 September 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

21 September 2018

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Staphylococcus aureus sortase transpeptidase SrtA: insight into the kinetic mechanism and evidence for a reverse protonation catalytic mechanism

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Crystal structures representing the Michaelis complex and the thiouronium reaction intermediate of Pseudomonas aeruginosa arginine deiminase.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Arginine deiminase uses an active-site cysteine in nucleophilic catalysis of L-arginine hydrolysis

21 September 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

21 September 2018

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Crystal structures of arginine deiminase with covalent reaction intermediates; implications for catalytic mechanism.

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

21 September 2018

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Anisylazoformylarginine: a superior assay substrate for carboxypeptidase B type enzymes

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

21 September 2018

https://www.researchgate.net/publication/6334053_Protein_Arginine_Deiminase_4_Evidence_for_a_Reverse_Protonation_Mechanism#references

Deimination of arginine residues in nucleophosmin/B23 and histones in HL-60 granulocytes

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism † | Request PDF (English)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212595

Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa

21 September 2018

1 reference

12 December 2020

The guanidino-group modifying enzymes: structural basis for their diversity and commonality

1 reference

12 December 2020

Arginine deiminase: demonstration of two active sites and possible half-of-the-sites reactivity

1 reference

12 December 2020

Solvent isotope effects on the rates of alkylation of thiolamine models of papain

1 reference

12 December 2020

Effect of cysteine-25 on the ionization of histidine-159 in papain as determined by proton nuclear magnetic resonance spectroscopy. Evidence for a his-159--Cys-25 ion pair and its possible role in catalysis

1 reference

12 December 2020

The use of pH studies to determine chemical mechanisms of enzyme-catalyzed reactions

1 reference

12 December 2020

Roles of aspartic acid-181 and serine-222 in intermediate formation and hydrolysis of the mammalian protein-tyrosine-phosphatase PTP1

1 reference

12 December 2020

The COOH Terminus of Aminoglycoside Phosphotransferase (3′)-IIIa Is Critical for Antibiotic Recognition and Resistance

1 reference

12 December 2020

Identifiers

DOI

10.1021/BI700095S

1 reference

14 August 2017

1 reference

14 August 2017

1 reference

PMCID

2212595