Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity (Q36399980)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity (English)

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16 February 2020

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5

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16 February 2020

author name string

Kaidong Zhang

1

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16 February 2020

Brian M Shafer

2

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16 February 2020

Matthew D Demars

3

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16 February 2020

Harry A Stern

4

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16 February 2020

language of work or name

English

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publication date

2 November 2012

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Journal of the American Chemical Society

16 February 2020

published in

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16 February 2020

volume

134

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16 February 2020

issue

45

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16 February 2020

page(s)

18695-18704

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A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.

16 February 2020

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Qinghaosu (Artemisinin): The Price of Success

30 September 2017

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A medicinal chemistry perspective on artemisinin and related endoperoxides

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30 September 2017

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30 September 2017

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28 June 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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21 September 2018

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Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution

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21 October 2018

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21 October 2018

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12 December 2020

A Single Mutation in Cytochrome P450 BM3 Changes Substrate Orientation in a Catalytic Intermediate and the Regiospecificity of Hydroxylation†

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Late-stage intermolecular CH activation for lead diversification: a highly chemoselective oxyfunctionalization of the C-9 position of potent bryostatin analogues

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Identifiers

DOI

10.1021/JA3073462

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23121379%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

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16 February 2020

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