TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury (Q36387273)

13 August 2017

TGF-β-SMAD3 signaling mediates hepatic bile acid and phospholipid metabolism following lithocholic acid-induced liver injury (English)

1 reference

13 August 2017

Hans Luecke

8

0 references

Lalage M Wakefield

object named as

Lalage M Wakefield

9

0 references

author name string

Tsutomu Matsubara

1

1 reference

13 August 2017

Naoki Tanaka

2

1 reference

13 August 2017

Misako Sato

3

1 reference

13 August 2017

Dong Wook Kang

4

1 reference

13 August 2017

Kristopher W Krausz

5

1 reference

13 August 2017

Kathleen C Flanders

6

1 reference

13 August 2017

Kazuo Ikeda

7

1 reference

13 August 2017

Frank J Gonzalez

10

1 reference

13 August 2017

3 October 2012

1 reference

Journal of Lipid Research

13 August 2017

1 reference

13 August 2017

53

1 reference

13 August 2017

12

1 reference

13 August 2017

2698-2707

1 reference

Metabolomics reveals an essential role for peroxisome proliferator-activated receptor α in bile acid homeostasis.

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Pediatric nonalcoholic fatty liver disease: a multidisciplinary approach.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Smad phosphoisoform signals in acute and chronic liver injury: similarities and differences between epithelial and mesenchymal cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Lithocholic acid disrupts phospholipid and sphingolipid homeostasis leading to cholestasis in mice.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Organic anion transporting polypeptides (OATPs): regulation of expression and function.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

The coagulation system contributes to alphaVbeta6 integrin expression and liver fibrosis induced by cholestasis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Plasma metabolomic profile in nonalcoholic fatty liver disease.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Urinary metabolomics in Fxr-null mice reveals activated adaptive metabolic pathways upon bile acid challenge

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Expression of TGF-beta signaling factors in invasive breast cancers: relationships with age at diagnosis and tumor characteristics

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Role of alphavbeta6 integrin in acute biliary fibrosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

The effect of peroxisome-proliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes

30 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

30 September 2017

https://api.crossref.org/works/10.1194%2FJLR.M031773

Role of transforming growth factor beta 1 on hepatic regeneration and apoptosis in liver diseases

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Regulation of bile acid synthesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Fibroblast growth factor 19 treatment ameliorates disruption of hepatic lipid metabolism in farnesoid X receptor (Fxr)-null mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Themes in fibrosis and gastrointestinal inflammation

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

28 June 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Regulation of drug transporters by the farnesoid X receptor in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

FXR signaling in the enterohepatic system

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Tumor necrosis factor alpha-dependent up-regulation of Lrh-1 and Mrp3(Abcc3) reduces liver injury in obstructive cholestasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

3-ketocholanoic acid is the major in vitro human hepatic microsomal metabolite of lithocholic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Novel pathways of bile acid metabolism involving CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Possible protective role of pregnenolone-16 alpha-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Induction of hepatic transporters multidrug resistance-associated proteins (Mrp) 3 and 4 by clofibrate is regulated by peroxisome proliferator-activated receptor alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031773

Diagnostic effectiveness of serum bile acids in liver diseases as evaluated by multivariate statistical methods.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494264

Diagnosis of nonalcoholic fatty liver disease in children and adolescents: position paper of the ESPGHAN Hepatology Committee

21 September 2018

1 reference

12 December 2020

Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription

1 reference

12 December 2020

Tumor necrosis factor-alpha and interleukin-6 reduce bile canalicular contractions of rat hepatocytes

1 reference

12 December 2020

In situ localization of the hepatocytic Na+/Taurocholate cotransporting polypeptide in rat liver

1 reference

12 December 2020

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump

1 reference

12 December 2020

Identifiers

DOI

10.1194/JLR.M031773

1 reference

13 August 2017

1 reference

13 August 2017

PubMed publication ID

23034213

1 reference