A physiologically based in silico kinetic model predicting plasma cholesterol concentrations in humans (Q36387268)

13 August 2017

A physiologically based in silico kinetic model predicting plasma cholesterol concentrations in humans (English)

1 reference

13 August 2017

1 reference

3

Ben van Ommen

0 references

author name string

Niek C A van de Pas

1

1 reference

13 August 2017

Ruud A Woutersen

2

1 reference

13 August 2017

Ben van Ommen

3

1 reference

13 August 2017

Ivonne M C M Rietjens

4

1 reference

13 August 2017

Albert A de Graaf

5

1 reference

13 August 2017

29 September 2012

1 reference

Journal of Lipid Research

13 August 2017

1 reference

13 August 2017

53

1 reference

13 August 2017

12

1 reference

13 August 2017

2734-2746

1 reference

Parameter adaptations during phenotype transitions in progressive diseases.

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Biological, clinical and population relevance of 95 loci for blood lipids

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Systematic construction of a conceptual minimal model of plasma cholesterol levels based on knockout mouse phenotypes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Improved cholesterol phenotype analysis by a model relating lipoprotein life cycle processes to particle size

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Use of physiologically based biokinetic (PBBK) modeling to study estragole bioactivation and detoxification in humans as compared with male rats.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

ABCA1 plays no role in the centripetal movement of cholesterol from peripheral tissues to the liver and intestine in the mouse

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Mechanism of inhibition defines CETP activity: a mathematical model for CETP in vitro

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Dynamical modeling of the cholesterol regulatory pathway with Boolean networks

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Origins of intestinal ABCA1-mediated HDL-cholesterol

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Computational lipidology: predicting lipoprotein density profiles in human blood plasma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Heart Disease and Stroke Statistics--2008 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Effects of torcetrapib in patients at high risk for coronary events

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Management of lipids in the prevention of cardiovascular events

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Efficacy and safety of torcetrapib, a novel cholesteryl ester transfer protein inhibitor, in individuals with below-average high-density lipoprotein cholesterol levels

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

The molecular basis of lecithin:cholesterol acyltransferase deficiency syndromes: a comprehensive study of molecular and biochemical findings in 13 unrelated Italian families

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Comparative effects of lipid-lowering therapies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Control of cholesterol turnover in the mouse

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Use of in vitro data for construction of a physiologically based pharmacokinetic model for naphthalene in rats and mice to probe species differences

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Smith-Lemli-Opitz syndrome is caused by mutations in the 7-dehydrocholesterol reductase gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Smith-Lemli-Opitz syndrome: deficient delta 7-reductase activity in cultured skin fibroblasts and chorionic villus fibroblasts and its application to pre- and postnatal detection.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Dietary lipids and blood cholesterol: quantitative meta-analysis of metabolic ward studies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Cholesterol distribution in the bulk tissues of man: variation with age

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Cholesterol synthesis in the intestine of man: regional differences and control mechanisms

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

A molecular defect causing fish eye disease: an amino acid exchange in lecithin-cholesterol acyltransferase (LCAT) leads to the selective loss of alpha-LCAT activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

A frameshift mutation in the human apolipoprotein A-I gene causes high density lipoprotein deficiency, partial lecithin: cholesterol-acyltransferase deficiency, and corneal opacities

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Effects of obesity and caloric intake on biliary lipid metabolism in man

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Measurement of daily cholesterol synthesis rates in man by assay of the fractional conversion of mevalonic acid to cholesterol

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Effect of a coffee lipid (cafestol) on regulation of lipid metabolism in CaCo-2 cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Good news for 'good' cholesterol

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Delayed increase in high density lipoprotein-phospholipids after ingestion of a fat load in normolipidemic patients with coronary artery disease.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Lipoprotein heterogeneity and apolipoprotein B metabolism

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Physiological parameter values for physiologically based pharmacokinetic models

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Reduced high density lipoprotein cholesterol in human cholesteryl ester transfer protein transgenic mice

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Cholesterol absorption and synthesis related to low density lipoprotein metabolism during varying cholesterol intake in men with different apoE phenotypes.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3494263

Differences in simulated liver concentrations of toxic coumarin metabolites in rats and different human populations evaluated through physiologically based biokinetic (PBBK) modeling.

28 June 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

A computer model of the gene network of the cholesterol biosynthesis regulation in the cell: analysis of the effect of mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

Trends in serum lipids and lipoproteins of adults, 1960-2002.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

Development and application of physiologically based pharmacokinetic-modeling tools to support drug discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

A physiologically based pharmacokinetic (PB-PK) model for 1,2-dichlorobenzene linked to two possible parameters of toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

Free cholesterol-induced cytotoxicity a possible contributing factor to macrophage foam cell necrosis in advanced atherosclerotic lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

Lipoprotein cholesteryl ester production, transfer, and output in vivo in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

A pathway model of lipid metabolism to predict the effect of genetic variability on lipid levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

Quantitative evaluation of sebum lipid components with nuclear magnetic resonance

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

Comparison of apolipoprotein B metabolism in familial defective apolipoprotein B and heterogeneous familial hypercholesterolemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

Physiologically Based Pharmacokinetic Modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

Statins, High-Density Lipoprotein Cholesterol, and Regression of Coronary Atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1194%2FJLR.M031930

A physiologically-based kinetic model for the prediction of plasma cholesterol concentrations in the mouse

21 January 2018

1 reference

12 December 2020

Cholesterol absorption: regulation of cholesterol synthesis and elimination and within-population variations of serum cholesterol levels

1 reference

12 December 2020

Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E

1 reference

12 December 2020

The surface cholesteryl ester content of donor and acceptor particles regulates CETP: a liposome-based approach to assess the substrate properties of lipoproteins

1 reference

12 December 2020

Decreased cellular cholesterol efflux is a common cause of familial hypoalphalipoproteinemia: role of the ABCA1 gene mutations

1 reference

12 December 2020

Pitfalls in measuring plasma cholesterol in the Smith-Lemli-Opitz syndrome

1 reference

12 December 2020

A pool of reversibly cell-associated cholesteryl esters involved in the selective uptake of cholesteryl esters from high-density lipoproteins by Hep G2 hepatoma cells

1 reference

12 December 2020

Accumulation of 7 alpha-hydroxycholesterol in liver tissue of patients with cholesterol gallstones

1 reference

12 December 2020

Excretion rate and composition of skin surface lipids on the foreheads of adult males with type IV hyperlipoproteinemia

1 reference

12 December 2020

A minimal model for human whole body cholesterol metabolism

1 reference

12 December 2020

Erythrocyte volume, plasma volume, and lean body mass in adult men and women

1 reference

12 December 2020

TISSUE DISTRIBUTION OF CHOLESTEROL AND 24-DEHYDROCHOLESTEROL DURING CHRONIC TRIPARANOL THERAPY

1 reference

12 December 2020

Identifiers

DOI

10.1194/JLR.M031930

1 reference

13 August 2017

1 reference

13 August 2017

1 reference