Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization (Q36380741)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9334368%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

title

Inhibition of virus attachment to CD4+ target cells is a major mechanism of T cell line-adapted HIV-1 neutralization (English)

1 reference

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6 November 2019

0 references

0 references

1

1 reference

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6 November 2019

Paul Whi Parren

3

1 reference

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6 November 2019

6

P J Klasse

1 reference

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6 November 2019

author name string

I Mondor

2

1 reference

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6 November 2019

D R Burton

4

1 reference

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6 November 2019

S A Tilley

5

1 reference

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6 November 2019

Q J Sattentau

7

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6 November 2019

language of work or name

English

0 references

publication date

1 October 1997

1 reference

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Journal of Experimental Medicine

6 November 2019

published in

1 reference

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6 November 2019

volume

186

1 reference

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6 November 2019

page(s)

1287-1298

1 reference

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6 November 2019

issue

8

1 reference

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A human IgG1 (b12) specific for the CD4 binding site of HIV-1 neutralizes by inhibiting the virus fusion entry process, but b12 Fab neutralizes by inhibiting a postfusion event

6 November 2019

cites work

1 reference

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Microvesicles are a source of contaminating cellular proteins found in purified HIV-1 preparations

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Soluble CD4 induces the binding of human immunodeficiency virus type 1 to cells via the V3 loop of glycoprotein 120 and specific sites in glycoprotein 41.

30 September 2017

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Synergistic neutralization of human immunodeficiency virus type 1 by a chimpanzee monoclonal antibody against the V2 domain of gp120 in combination with monoclonal antibodies against the V3 loop and the CD4-binding site

30 September 2017

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Quantitative model of antibody- and soluble CD4-mediated neutralization of primary isolates and T-cell line-adapted strains of human immunodeficiency virus type 1.

30 September 2017

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Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein.

30 September 2017

1 reference

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Neutralizing antibodies to human immunodeficiency virus type-1 gp120 induce envelope glycoprotein subunit dissociation.

30 September 2017

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Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1

30 September 2017

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Molecular profile of an antibody response to HIV-1 as probed by combinatorial libraries

30 September 2017

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V3-specific neutralizing antibodies in sera from HIV-1 gp160-immunized volunteers block virus fusion and act synergistically with human monoclonal antibody to the conformation-dependent CD4 binding site of gp120. NIH-NIAID AIDS Vaccine Clinical Tria

30 September 2017

1 reference

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Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1.

30 September 2017

1 reference

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Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization

30 September 2017

1 reference

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Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody

30 September 2017

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Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D

30 September 2017

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Growth of macrophage-tropic and primary human immunodeficiency virus type 1 (HIV-1) isolates in a unique CD4+ T-cell clone (PM1): failure to downregulate CD4 and to interfere with cell-line-tropic HIV-1.

30 September 2017

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Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding

30 September 2017

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A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1

30 September 2017

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Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding

30 September 2017

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Structure of human rhinovirus complexed with Fab fragments from a neutralizing antibody.

30 September 2017

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Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding

30 September 2017

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Human immunodeficiency virus type 1 neutralization is determined by epitope exposure on the gp120 oligomer

30 September 2017

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A human monoclonal antibody to a complex epitope in the V3 region of gp120 of human immunodeficiency virus type 1 has broad reactivity within and outside clade B.

30 September 2017

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Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.

30 September 2017

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A novel, glycan-dependent epitope in the V2 domain of human immunodeficiency virus type 1 gp120 is recognized by a highly potent, neutralizing chimpanzee monoclonal antibody.

30 September 2017

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30 September 2017

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Native oligomeric human immunodeficiency virus type 1 envelope glycoprotein elicits diverse monoclonal antibody reactivities.

30 September 2017

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Role of CD4 endocytosis in human immunodeficiency virus infection.

30 September 2017

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Cross-clade neutralization of primary isolates of human immunodeficiency virus type 1 by human monoclonal antibodies and tetrameric CD4-IgG.

30 September 2017

1 reference

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Neutralizing antibodies to visna lentivirus: mechanism of action and possible role in virus persistence

30 September 2017

1 reference

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Neutralizing antibodies to an immunodominant envelope sequence do not prevent gp120 binding to CD4.

30 September 2017

1 reference

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HIV infection is blocked in vitro by recombinant soluble CD4.

30 September 2017

1 reference

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Generation and characterization of monoclonal antibodies to the putative CD4-binding domain of human immunodeficiency virus type 1 gp120.

30 September 2017

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Effects of anti-gp120 monoclonal antibodies on CD4 receptor binding by the env protein of human immunodeficiency virus type 1

30 September 2017

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Binding of the human retrovirus HTLV-III/LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry

30 September 2017

1 reference

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Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4.

30 September 2017

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Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization

30 September 2017

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Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates

30 September 2017

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A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals

30 September 2017

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Characterization of a discontinuous human immunodeficiency virus type 1 gp120 epitope recognized by a broadly reactive neutralizing human monoclonal antibody

30 September 2017

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Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding

30 September 2017

1 reference

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Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding

30 September 2017

1 reference

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Human immunodeficiency virus type 1 NL4-3 replication in four T-cell lines: rate and efficiency of entry, a major determinant of permissiveness

30 September 2017

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Human immunodeficiency virus type 1 entry into T cells: more-rapid escape from an anti-V3 loop than from an antireceptor antibody

30 September 2017

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Neutralization of diverse human immunodeficiency virus type 1 variants by an anti-V3 human monoclonal antibody

30 September 2017

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Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro

30 September 2017

1 reference

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Synergistic interaction between ligands binding to the CD4 binding site and V3 domain of human immunodeficiency virus type I gp120

30 September 2017

1 reference

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Antibody neutralization of HIV-1.

30 September 2017

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The antibody response in HIV-1 infection.

30 September 2017

1 reference

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Cell membrane vesicles are a major contaminant of gradient-enriched human immunodeficiency virus type-1 preparations

28 June 2018

1 reference

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Synergistic inhibition of HIV-1 by CD4 binding domain reagents and V3-directed monoclonal antibodies

28 June 2018

1 reference

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Topographical analysis of viral epitopes using monoclonal antibodies: Mechanism of virus neutralization

28 June 2018

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Functional and neutralization profile of seven overlapping antigenic sites on the HN glycoprotein of Newcastle disease virus: monoclonal antibodies to some sites prevent viral attachment

28 June 2018

1 reference

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Dissociation of gp120 from HIV-1 virions induced by soluble CD4.

28 June 2018

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A human monoclonal antibody against the CD4-binding site of HIV1 gp120 exhibits potent, broadly neutralizing activity

28 June 2018

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An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infection

28 June 2018

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Analysis of synergism/antagonism between HIV-1 antibody-positive human sera and soluble CD4 in blocking HIV-1 binding and infectivity

28 June 2018

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Synergistic neutralization of HIV-1 by human monoclonal antibodies against the V3 loop and the CD4-binding site of gp120

28 June 2018

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Two neutralizing anti-V3 monoclonal antibodies act by affecting different functions of human immunodeficiency virus type 1.

28 June 2018

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Neutralizing monoclonal antibodies to the AIDS virus

21 January 2018

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Biologically diverse molecular variants within a single HIV-1 isolate

21 September 2018

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Second conserved domain of gp120 is important for HIV infectivity and antibody neutralization

21 January 2018

1 reference

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21 January 2018

Too much of a good thing

1 reference

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Bathophenanthroline Disulfonate and Soluble CD4 as Probes for Early Events of HIV Type 1 Entry

21 January 2018

1 reference

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A molecular mechanism of inhibition of HIV-1 binding to CD4+ cells by monoclonal antibodies to gp110

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9334368

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neutralization of animal viruses

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9334368

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two major groups of neutralizing anti-gp120 antibodies exist in HIV-infected individuals. Evidence for epitope diversity around the CD4 attachment site

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/9334368

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.186.8.1287

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9334368%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9334368%20AND%20SRC:MED&resulttype=core&format=json

6 November 2019

1 reference