Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain. (Q36379547)

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English	Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain.	scientific article

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12 February 2020

Thioredoxin-80 is a product of alpha-secretase cleavage that inhibits amyloid-beta aggregation and is decreased in Alzheimer's disease brain (English)

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12 February 2020

Alzheimer's disease

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Francisco J Gil-Bea

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12 February 2020

Angel Gutiérrez-Rodríguez

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12 February 2020

Angel Cedazo-Minguez

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12 February 2020

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Susanne Akterin

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12 February 2020

Torbjörn Persson

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12 February 2020

Laura Mateos

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12 February 2020

Anna Sandebring

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12 February 2020

Javier Avila-Cariño

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12 February 2020

Erik Sundström

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12 February 2020

Arne Holmgren

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12 February 2020

Bengt Winblad

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12 February 2020

publication date

30 August 2012

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12 February 2020

EMBO Molecular Medicine

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12 February 2020

4

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12 February 2020

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12 February 2020

1097-1111

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12 February 2020

The characterization of the Caenorhabditis elegans mitochondrial thioredoxin system uncovers an unexpected protective role of thioredoxin reductase 2 in β-amyloid peptide toxicity

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30 September 2017

α-Secretase in Alzheimer's disease and beyond: mechanistic, regulation and function in the shedding of membrane proteins

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30 September 2017

Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2.

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Molecular basis for insulin fibril assembly

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Biomarkers for Alzheimer's disease and other forms of dementia: clinical needs, limitations and future aspects

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Thioredoxin and related molecules--from biology to health and disease

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Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's disease.

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Truncated thioredoxin: physiological functions and mechanism

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In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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[alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients

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Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome

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Physiological functions of thioredoxin and thioredoxin reductase

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Production and secretion of thioredoxin from transformed human trophoblast cells.

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Thioredoxin expression and localization in human cell lines: detection of full-length and truncated species

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Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer

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Macroautophagy-generated increase of lysosomal amyloid β-protein mediates oxidant-induced apoptosis of cultured neuroblastoma cells

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28 June 2018

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28 June 2018

Truncated thioredoxin (Trx80) exerts unique mitogenic cytokine effects via a mechanism independent of thiol oxido-reductase activity

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Human eosinophil cytotoxicity-enhancing factor. II. Multiple forms synthesized by U937 cells and their relationship to thioredoxin/adult T cell leukemia-derived factor.

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alpha- and beta-secretase: profound changes in Alzheimer's disease.

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21 September 2018

Truncated thioredoxin (Trx80) induces production of interleukin-12 and enhances CD14 expression in human monocytes

1 reference

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12 December 2020

based on heuristic

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Effects of apolipoprotein E (apoE) isoforms, beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22933306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arrest of beta-amyloid fibril formation by a pentapeptide ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/22933306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Truncated thioredoxin is a mitogenic cytokine for resting human peripheral blood mononuclear cells and is present in human plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22933306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Properties and biological activities of thioredoxins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22933306

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nitric oxide synthases: structure, function and inhibition

1 reference

https://api.crossref.org/works/10.1002%2FEMMM.201201462

7 January 2021

based on heuristic

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Identifiers

10.1002/EMMM.201201462

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12 February 2020

1 reference

Europe PubMed Central

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12 February 2020

1 reference

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12 February 2020

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