Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence (Q36374210)

13 August 2017

Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence (English)

1 reference

13 August 2017

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1 reference

ChEBI release 2020-05-28

ChEBI ID

9168

pneumococcal pneumonia

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1 reference

7

Carlos J Orihuela

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13 August 2017

5

Richard A Miller

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13 August 2017

Cecilia A Hinojosa

1

1 reference

13 August 2017

Victoria Mgbemena

2

1 reference

13 August 2017

Sabrina Van Roekel

3

1 reference

13 August 2017

Steven N Austad

4

1 reference

13 August 2017

Santanu Bose

6

1 reference

13 August 2017

7 September 2012

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13 August 2017

Experimental Gerontology

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13 August 2017

47

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13 August 2017

958-965

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13 August 2017

12

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Inhibition of autophagy ameliorates acute lung injury caused by avian influenza A H5N1 infection.

13 August 2017

1 reference

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pRB, a tumor suppressor with a stabilizing presence

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Age-associated increase in heterochromatic marks in murine and primate tissues

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

30 September 2017

1 reference

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Novel regulators and drug targets of cardiac hypertrophy

30 September 2017

1 reference

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New inhibitors of the mammalian target of rapamycin signaling pathway for cancer.

30 September 2017

1 reference

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Rapamycin can inhibit the development of Chlamydia pneumoniae, which might partly contribute to the prevention of in-stent restenosis

30 September 2017

1 reference

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

30 September 2017

1 reference

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

30 September 2017

1 reference

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Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments

30 September 2017

1 reference

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mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells

30 September 2017

1 reference

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CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury

30 September 2017

1 reference

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Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

30 September 2017

1 reference

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The Streptococcus pneumoniae adhesin PsrP binds to Keratin 10 on lung cells

30 September 2017

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

30 September 2017

1 reference

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Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumonia

30 September 2017

1 reference

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mTOR regulates memory CD8 T-cell differentiation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Rapamycin decelerates cellular senescence

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Growth stimulation leads to cellular senescence when the cell cycle is blocked

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Cellular senescence: when bad things happen to good cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Deaths: preliminary data for 2004.

30 September 2017

1 reference

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The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability

30 September 2017

1 reference

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Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data

30 September 2017

1 reference

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Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Nontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expression.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Staphylococcus aureus clumping factor B (ClfB) promotes adherence to human type I cytokeratin 10: implications for nasal colonization

30 September 2017

1 reference

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Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Non-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptor

30 September 2017

1 reference

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Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Rapamycin inhibits IL-4--induced dendritic cell maturation in vitro and dendritic cell mobilization and function in vivo

30 September 2017

1 reference

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Inhibition of mammalian target of rapamycin augments lipopolysaccharide-induced lung injury and apoptosis.

28 June 2018

1 reference

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Etiology of community-acquired pneumonia: increased microbiological yield with new diagnostic methods.

21 September 2018

1 reference

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Novel phosphorylcholine-containing protein of Pseudomonas aeruginosa chronic infection isolates interacts with airway epithelial cells

21 September 2018

1 reference

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Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Tissue-specific contributions of pneumococcal virulence factors to pathogenesis

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3490008

Opportunistic mycelial fungal infections in organ transplant recipients: emerging importance of non-Aspergillus mycelial fungi.

21 September 2018

1 reference

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Cell biology. Rapamycin paradox resolved

21 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22981852

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Changing epidemiology of invasive pneumococcal disease among older adults in the era of pediatric pneumococcal conjugate vaccine

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22981852

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.EXGER.2012.08.013

1 reference

13 August 2017

1 reference

13 August 2017

1 reference