Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation. (Q36369402)

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English	Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation.	scientific article

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9 November 2019

Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation (English)

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9 November 2019

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Richard M. Pope

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9 November 2019

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H Liu

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9 November 2019

H Perlman

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9 November 2019

L J Pagliari

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1 July 2001

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9 November 2019

Journal of Experimental Medicine

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9 November 2019

194

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9 November 2019

113-126

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9 November 2019

2

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9 November 2019

Macrophages require constitutive NF-kappaB activation to maintain A1 expression and mitochondrial homeostasis

1 reference

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30 September 2017

Akt regulates cell survival and apoptosis at a postmitochondrial level

1 reference

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30 September 2017

Role of BAX in the apoptotic response to anticancer agents

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30 September 2017

ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice

1 reference

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30 September 2017

Two distinct pathways leading to nuclear apoptosis

1 reference

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30 September 2017

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

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30 September 2017

TNF-alpha gene expression in macrophages: regulation by NF-kappa B is independent of c-Jun or C/EBP beta

1 reference

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30 September 2017

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Mcl-1 deficiency results in peri-implantation embryonic lethality

1 reference

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30 September 2017

FLICE-inhibitory protein expression during macrophage differentiation confers resistance to fas-mediated apoptosis

1 reference

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30 September 2017

Cellular survival: a play in three Akts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Hematopoietic, immunomodulatory and epithelial effects of interleukin-11.

1 reference

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30 September 2017

The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Induction of NF-kappaB by the Akt/PKB kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-kappaB activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Mitochondrial release of caspase-2 and -9 during the apoptotic process

1 reference

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30 September 2017

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Regulation of cell death protease caspase-9 by phosphorylation

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30 September 2017

Mcl-1 in transgenic mice promotes survival in a spectrum of hematopoietic cell types and immortalization in the myeloid lineage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Lysophosphatidic acid is a major serum noncytokine survival factor for murine macrophages which acts via the phosphatidylinositol 3-kinase signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity

1 reference

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30 September 2017

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line

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30 September 2017

Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria

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30 September 2017

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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30 September 2017

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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30 September 2017

Human A1, a Bcl-2-related gene, is induced in leukemic cells by cytokines as well as differentiating factors

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30 September 2017

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

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30 September 2017

Role of cytokines in rheumatoid arthritis

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30 September 2017

A1, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Immunohistochemical analysis of Mcl-1 protein in human tissues. Differential regulation of Mcl-1 and Bcl-2 protein production suggests a unique role for Mcl-1 in control of programmed cell death in vivo.

1 reference

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30 September 2017

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

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30 September 2017

PI3K: downstream AKTion blocks apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

30 September 2017

Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B.

1 reference

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28 June 2018

Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells.

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28 June 2018

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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28 June 2018

Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

21 September 2018

1alpha,25-dihydroxyvitamin D(3)-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

21 September 2018

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2193455

21 September 2018

Impaired Fas response and autoimmunity in Pten+/- mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional consequences of the sustained or transient activation by Bax of the mitochondrial permeability transition pore

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD45-induced tumor necrosis factor alpha production in monocytes is phosphatidylinositol 3-kinase-dependent and nuclear factor-kappaB-independent

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinase as a mediator of TNF-induced NF-kappa B activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiapoptotic action of 1,25-dihydroxyvitamin D3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome c

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protection of CD95-mediated apoptosis by activation of phosphatidylinositide 3-kinase and protein kinase B

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteases to die for

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MRL/lpr and MRL+/+ macrophage DNA synthesis in the absence and the presence of colony-stimulating factor-1 and granulocyte-macrophage colony-stimulating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The possible role of apoptosis-suppressing genes, bcl-2 and mcl-1/EAT in human adrenal tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11457886

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.194.2.113

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11457886%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11457886%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11457886%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

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