The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity (Q36359800)

13 August 2017

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity (English)

1 reference

13 August 2017

1 reference

10

Michael S Diamond

0 references

Bimmi Shrestha

3

object named as

Bimmi Shrestha

1 reference

13 August 2017

Helen M Lazear

6

0 references

Jose Luiz Proenca-Modena

object named as

Jose L Proenca-Modena

4

0 references

Jonathan J Miner

1

object named as

Jonathan J Miner

1 reference

13 August 2017

7

Matthew J Gorman

1 reference

13 August 2017

Brian P Daniels

2

1 reference

13 August 2017

Erin D Lew

5

1 reference

13 August 2017

Greg Lemke

8

1 reference

13 August 2017

Robyn S Klein

9

1 reference

13 August 2017

language of work or name

English

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publication date

2 November 2015

1 reference

13 August 2017

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13 August 2017

21

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13 August 2017

12

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13 August 2017

1464-1472

1 reference

https://scigraph.springernature.com/pub.10.1038/nm.3974

13 August 2017

0 references

cites work

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

1 reference

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Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities

30 September 2017

1 reference

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Diversification of TAM receptor tyrosine kinase function

30 September 2017

1 reference

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Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals

30 September 2017

1 reference

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Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection

30 September 2017

1 reference

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Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma

30 September 2017

1 reference

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The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.

30 September 2017

1 reference

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An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.

30 September 2017

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Replication cycle and molecular biology of the West Nile virus

30 September 2017

1 reference

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Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Biology of the TAM receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Pattern recognition receptor MDA5 modulates CD8+ T cell-dependent clearance of West Nile virus from the central nervous system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Systemic autoimmunity in TAM triple knockout mice causes inflammatory brain damage and cell death

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Therapeutic efficacy of Tyro3, Axl, and Mer tyrosine kinase agonists in collagen-induced arthritis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Critical role for interferon regulatory factor 3 (IRF-3) and IRF-7 in type I interferon-mediated control of murine norovirus replication

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Targeting Axl and Mer kinases in cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

TAM receptors are pleiotropic inhibitors of the innate immune response

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Protective capacity and epitope specificity of CD8(+) T cells responding to lethal West Nile virus infection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Antigen-specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases

30 September 2017

1 reference

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Protective immune responses against West Nile virus are primed by distinct complement activation pathways

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Multiple roles for the receptor tyrosine kinase axl in tumor formation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

30 September 2017

1 reference

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Role of CD8+ T cells in control of West Nile virus infection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

A Critical Role for Induced IgM in the Protection against West Nile Virus Infection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Rho GTPases in cell biology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Phagocytosis and clearance of apoptotic cells is mediated by MER.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

La Crosse encephalitis in children

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Expression of the receptor protein-tyrosine kinases Tyro-3, Axl, and mer in the developing rat central nervous system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activat

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer.

28 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

The vitamin K-dependent anticoagulant factor, protein S, inhibits multiple VEGF-A-induced angiogenesis events in a Mer- and SHP2-dependent manner.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

Inhibitors of the TAM subfamily of tyrosine kinases: synthesis and biological evaluation

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

An SH2 domain-dependent, phosphotyrosine-independent interaction between Vav1 and the Mer receptor tyrosine kinase: a mechanism for localizing guanine nucleotide-exchange factor action

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4674389

TAM receptor function in the retinal pigment epithelium

22 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3974

Blocking Monoclonal Antibodies Specific for Mouse IFN-α/β Receptor Subunit 1 (IFNAR-1) from Mice Immunized by In Vivo Hydrodynamic Transfection

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.3974

First Axl inhibitor enters clinical trials

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26523970

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NM.3974

1 reference

Dimensions Publication ID

13 August 2017

1022540248

0 references

Fatcat ID

release_ary33rsidvhkzaa2fjck2wq52i

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ary33rsidvhkzaa2fjck2wq52i

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

13 August 2017

1 reference