Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2 (Q36354944)

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English	Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2	scientific article

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scholarly article

1 reference

Europe PubMed Central

13 August 2017

Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2 (English)

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Europe PubMed Central

13 August 2017

spinocerebellar ataxia type 2

1 reference

based on heuristic

inferred from title

Palle Christophersen

11

object named as

Palle Christophersen

1 reference

Europe PubMed Central

13 August 2017

author name string

Adebimpe W Kasumu

1

1 reference

Europe PubMed Central

13 August 2017

Charlotte Hougaard

2

1 reference

Europe PubMed Central

13 August 2017

Frederik Rode

3

1 reference

Europe PubMed Central

13 August 2017

Thomas A Jacobsen

4

1 reference

Europe PubMed Central

13 August 2017

Jean Marc Sabatier

5

1 reference

Europe PubMed Central

13 August 2017

Birgitte L Eriksen

6

1 reference

Europe PubMed Central

13 August 2017

Dorte Strøbæk

7

1 reference

Europe PubMed Central

13 August 2017

Xia Liang

8

1 reference

Europe PubMed Central

13 August 2017

Polina Egorova

9

1 reference

Europe PubMed Central

13 August 2017

Dasha Vorontsova

10

1 reference

Europe PubMed Central

13 August 2017

Lars Christian B Rønn

12

1 reference

Europe PubMed Central

13 August 2017

Ilya Bezprozvanny

13

1 reference

Europe PubMed Central

13 August 2017

publication date

1 October 2012

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Europe PubMed Central

13 August 2017

Chemistry and Biology

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Europe PubMed Central

13 August 2017

19

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Europe PubMed Central

13 August 2017

10

1 reference

Europe PubMed Central

13 August 2017

1340-1353

1 reference

Europe PubMed Central

13 August 2017

Therapeutic prospects for spinocerebellar ataxia type 2 and 3.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

K(Ca)2 and k(ca)3 channels in learning and memory processes, and neurodegeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Purkinje neuron synchrony elicits time-locked spiking in the cerebellar nuclei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Small-conductance Ca2+-activated K+ channels: form and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Ataxin-2 repeat-length variation and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

SK2 channel expression and function in cerebellar Purkinje cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Ataxias and cerebellar dysfunction: involvement of synaptic plasticity deficits?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Functional reduction of SK3-mediated currents precedes AMPA-receptor-mediated excitotoxicity in dopaminergic neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Calcium channel blocker use and risk of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

KCa channels as therapeutic targets in episodic ataxia type-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Deranged calcium signaling in Purkinje cells and pathogenesis in spinocerebellar ataxia 2 (SCA2) and other ataxias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

L-type calcium channel blockers and Parkinson disease in Denmark

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

In vivo pharmacological manipulation of small conductance Ca(2+)-activated K(+) channels influences motor behavior, object memory and fear conditioning

1 reference

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30 September 2017

Cellular and molecular pathways triggering neurodegeneration in the spinocerebellar ataxias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Antihypertensive agents and risk of Parkinson's disease, essential tremor and dementia: a population-based prospective study (NEDICES).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Emerging pathogenic pathways in the spinocerebellar ataxias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Calcium homeostasis, selective vulnerability and Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressure

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30 September 2017

Spinocerebellar ataxia 2 (SCA2).

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30 September 2017

Contextual memory deficits observed in mice overexpressing small conductance Ca2+-activated K+ type 2 (KCa2.2, SK2) channels are caused by an encoding deficit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Calcium, ageing, and neuronal vulnerability in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

On-beam synchrony in the cerebellum as the mechanism for the timing and coordination of movement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Trinucleotide Repeat Disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime)

1 reference

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30 September 2017

Ca(2+)-activated K+ channels: molecular determinants and function of the SK family

1 reference

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30 September 2017

Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Historical review of the significance of the cerebellum and the role of Purkinje cells in motor learning

1 reference

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30 September 2017

Small conductance Ca2+-activated K+ channels modulate synaptic plasticity and memory encoding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3483567

30 September 2017

Developmental regulation of small-conductance Ca2+-activated K+ channel expression and function in rat Purkinje neurons.

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30 September 2017

Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2.

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30 September 2017

Ca(2+) signaling in dendritic spines

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30 September 2017

Modulation of recombinant small-conductance Ca(2+)-activated K(+) channels by the muscle relaxant chlorzoxazone and structurally related compounds.

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30 September 2017

Nuclear localization or inclusion body formation of ataxin-2 are not necessary for SCA2 pathogenesis in mouse or human

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30 September 2017

Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons.

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30 September 2017

Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration

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30 September 2017

Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2.

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30 September 2017

Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices

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30 September 2017

Electrophysiological properties of in vitro Purkinje cell somata in mammalian cerebellar slices

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30 September 2017

Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain

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29 June 2018

The natural history of degenerative ataxia: a retrospective study in 466 patients.

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29 June 2018

Analysis of spontaneous electrical activity in cerebellar Purkinje cells acutely isolated from postnatal rats.

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29 June 2018

Riluzole in cerebellar ataxia: a randomized, double-blind, placebo-controlled pilot trial

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22 September 2018

A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease

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22 September 2018

Haploinsufficiency of AFG3L2, the gene responsible for spinocerebellar ataxia type 28, causes mitochondria-mediated Purkinje cell dark degeneration.

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22 September 2018

Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice

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22 September 2018

KCa2 channels transiently downregulated during spatial learning and memory in rats

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22 September 2018

SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors

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22 September 2018

High-frequency organization and synchrony of activity in the purkinje cell layer of the cerebellum

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22 September 2018

Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport.

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22 September 2018

Small-conductance Ca2+-activated K+ channel type 2 (SK2) modulates hippocampal learning, memory, and synaptic plasticity.

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22 September 2018

Transient high-frequency firing in a coupled-oscillator model of the mesencephalic dopaminergic neuron

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22 September 2018

Analysis of SCA-2 and SCA-3 repeats in Parkinsonism: evidence of SCA-2 expansion in a family with autosomal dominant Parkinson's disease.

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22 September 2018

Multiple mechanisms underlie burst firing in rat midbrain dopamine neurons in vitro

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22 September 2018

Somatic and dendritic small-conductance calcium-activated potassium channels regulate the output of cerebellar Purkinje neurons.

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22 September 2018

Modulation of the voltage-gated sodium- and calcium-dependent potassium channels in rat vestibular and facial nuclei after unilateral labyrinthectomy and facial nerve transsection: an in situ hybridization study.

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22 September 2018

Persistent changes in spontaneous firing of Purkinje neurons triggered by the nitric oxide signaling cascade.

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22 September 2018

Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons.

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22 September 2018

Regional differences in distribution and functional expression of small-conductance Ca2+-activated K+ channels in rat brain.

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22 September 2018

The frissonnant mutant mouse, a model of dopamino-sensitive, inherited motor syndrome

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22 September 2018

Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3.

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22 September 2018

Differential distribution of three Ca(2+)-activated K(+) channel subunits, SK1, SK2, and SK3, in the adult rat central nervous system.

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22 September 2018

Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons.

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22 September 2018

Use of antihypertensives and the risk of Parkinson disease

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21 October 2018

Profound alterations in the intrinsic excitability of cerebellar Purkinje neurons following neurotoxin 3-acetylpyridine (3-AP)-induced ataxia in rat: new insights into the role of small conductance K+ channels

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of apamin on the discharge properties of putative dopamine-containing neurons in vitro

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.CHEMBIOL.2012.07.013

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Europe PubMed Central

13 August 2017

release_4arwtocwgrhpvcd2ykbcxj3mou

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https://api.fatcat.wiki/v0/release/4arwtocwgrhpvcd2ykbcxj3mou

24 November 2022

based on heuristic

mapped directly with Wikidata item

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Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

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