Aurora A and B kinases as targets for cancer: will they be selective for tumors? (Q36352091)

13 August 2017

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title

Aurora A and B kinases as targets for cancer: will they be selective for tumors? (English)

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13 August 2017

Nick Matthews

1

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13 August 2017

Cristina Visintin

2

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13 August 2017

Basil Hartzoulakis

3

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13 August 2017

Ashley Jarvis

4

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13 August 2017

David L Selwood

5

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13 August 2017

1 January 2006

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Expert Review of Anticancer Therapy

13 August 2017

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13 August 2017

6

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13 August 2017

1

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13 August 2017

109-120

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Evolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugs

13 August 2017

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Genomic organization, expression, and chromosome localization of a third aurora-related kinase gene, Aie1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

The protein kinase complement of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

An antibody against DR4 (TRAIL-R1) in combination with doxorubicin selectively kills malignant but not normal prostate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Crystal structure of aurora-2, an oncogenic serine/threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

The cellular geography of aurora kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Regulation of Aurora-A kinase on the mitotic spindle

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Chromosomal passengers and the (aurora) ABCs of mitosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Cloning of STK13, a third human protein kinase related to Drosophila aurora and budding yeast Ipl1 that maps on chromosome 19q13.3-ter

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Protein kinase profile of sperm and eggs: cloning and characterization of two novel testis-specific protein kinases (AIE1, AIE2) related to yeast and fly chromosome segregation regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Overexpression and amplification of Aurora-A in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Aurora B overexpression associates with the thyroid carcinoma undifferentiated phenotype and is required for thyroid carcinoma cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Aurora B expression in normal testis and seminomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Survivin, versatile modulation of cell division and apoptosis in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Centrosomal kinases, HsAIRK1 and HsAIRK3, are overexpressed in primary colorectal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Structure-based design of novel anti-cancer agents targeting aurora kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Progress in the development of selective inhibitors of aurora kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Mechanism of Aurora B activation by INCENP and inhibition by hesperadin

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Structural basis of inhibitor selectivity in MAP kinases

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Characterization of a conserved structural determinant controlling protein kinase sensitivity to selective inhibitors.

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Features of selective kinase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Strategies to overcome resistance to targeted protein kinase inhibitors

21 January 2018

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https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Aurora-kinase inhibitors as anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

G1 tetraploidy checkpoint and the suppression of tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Arrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Potent and selective Aurora inhibitors identified by the expansion of a novel scaffold for protein kinase inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Molecular properties that influence the oral bioavailability of drug candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1586%2F14737140.6.1.109

21 January 2018

Identifiers

DOI

10.1586/14737140.6.1.109

1 reference

13 August 2017

1 reference