STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 (Q36351195)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22693070%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

title

STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3 (English)

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4 February 2020

1 reference

4

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4 February 2020

author name string

Woody Han

series ordinal

1

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4 February 2020

Richard L Carpenter

series ordinal

2

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4 February 2020

Xinyu Cao

series ordinal

3

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4 February 2020

publication date

12 June 2012

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4 February 2020

published in

Molecular Carcinogenesis

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4 February 2020

volume

52

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4 February 2020

issue

12

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4 February 2020

page(s)

959-969

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Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations

4 February 2020

cites work

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Hyperactive EGF receptor, Jaks and Stat3 signaling promote enhanced colony-forming ability, motility and migration of cisplatin-resistant ovarian cancer cells

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STAT3 is necessary for proliferation and survival in colon cancer-initiating cells

30 September 2017

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Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells.

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Retracted: A Functional Nuclear Epidermal Growth Factor Receptor, Src and Stat3 Heteromeric Complex in Pancreatic Cancer Cells

30 September 2017

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HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis

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Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells

30 September 2017

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EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: a potential mechanism of EGFR-driven antagonism of apoptosis

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Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3

30 September 2017

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Nuclear mode of the EGFR signaling network: biology, prognostic value, and therapeutic implications

30 September 2017

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Understanding resistance to EGFR inhibitors-impact on future treatment strategies

30 September 2017

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Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes

30 September 2017

1 reference

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EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance

30 September 2017

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Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors

30 September 2017

1 reference

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STATs in cancer inflammation and immunity: a leading role for STAT3

30 September 2017

1 reference

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A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion

30 September 2017

1 reference

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Nuclear EGFR contributes to acquired resistance to cetuximab

30 September 2017

1 reference

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The epidermal growth factor receptor: a link between inflammation and liver cancer.

30 September 2017

1 reference

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The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas.

30 September 2017

1 reference

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Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer

30 September 2017

1 reference

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Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Nuclear epidermal growth factor receptor (EGFR) interacts with signal transducer and activator of transcription 5 (STAT5) in activating Aurora-A gene expression

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.

30 September 2017

1 reference

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Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

30 September 2017

1 reference

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Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity

30 September 2017

1 reference

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The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus

30 September 2017

1 reference

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Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression

30 September 2017

1 reference

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Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications

30 September 2017

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Small molecule inhibitors of Stat3 signaling pathway.

30 September 2017

1 reference

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STAT1 as a key modulator of cell death

30 September 2017

1 reference

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Erbb2 regulates inflammation and proliferation in the skin after ultraviolet irradiation

30 September 2017

1 reference

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Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival.

30 September 2017

1 reference

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Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor

30 September 2017

1 reference

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Co-regulation of B-Myb expression by E2F1 and EGF receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Stat3 is required for the development of skin cancer

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

c-erbB-3: a nuclear protein in mammary epithelial cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Nuclear localization of EGF receptor and its potential new role as a transcription factor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

ErbB-2 kinase is required for constitutive stat 3 activation in malignant human lung epithelial cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Purification and characterization of epidermal growth factor receptor/protein kinase from normal mouse liver

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

A deletion mutation within the ligand binding domain is responsible for activation of epidermal growth factor receptor gene in human brain tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Structural alterations of the epidermal growth factor receptor gene in human gliomas

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivation

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Epidermal growth factor-receptor-protein kinase interactions

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

The role of HER1-HER4 and EGFRvIII in hormone-refractory prostate cancer

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Stat3 activation in prostatic carcinomas.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3482422

Potential use of an anticancer drug gefinitib, an EGFR inhibitor, on allergic airway inflammation

22 September 2018

1 reference

12 December 2020

SnapShot: EGFR signaling pathway

1 reference

12 December 2020

The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma

1 reference

12 December 2020

Epidermal growth factor-receptor-protein kinase interactions. Co-purification of receptor and epidermal growth factor-enhanced phosphorylation activity

1 reference

12 December 2020

Identifiers

DOI

10.1002/MC.21936

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22693070%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22693070%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22693070%20AND%20SRC:MED&resulttype=core&format=json