Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks. (Q36349861)

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29 February 2020

title

Non-redundant Functions of ATM and DNA-PKcs in Response to DNA Double-Strand Breaks (English)

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29 February 2020

1

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29 February 2020

Thomas Clouaire

3

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29 February 2020

Felipe Cortes Ledesma

10

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29 February 2020

author name string

Jonathan Choudjaye

2

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29 February 2020

Béatrix Bugler

4

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29 February 2020

Virginie Daburon

5

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29 February 2020

Marion Aguirrebengoa

6

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29 February 2020

Thomas Mangeat

7

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29 February 2020

Jason S Iacovoni

8

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29 February 2020

Alejandro Álvarez-Quilón

9

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29 February 2020

Gaëlle Legube

11

1 reference

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29 February 2020

publication date

12 November 2015

1 reference

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29 February 2020

number of pages

12

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based on heuristic

inferred from page(s)

published in

Cell Reports

1 reference

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volume

13

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29 February 2020

page(s)

1598-1609

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29 February 2020

issue

8

1 reference

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DNA double strand break repair pathway choice: a chromatin based decision?

29 February 2020

cites work

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair

30 September 2017

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DNA damage response: three levels of DNA repair regulation

30 September 2017

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Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks

30 September 2017

1 reference

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Genome-wide profiles of H2AX and γ-H2AX differentiate endogenous and exogenous DNA damage hotspots in human cells

30 September 2017

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Spatial organization of the mouse genome and its role in recurrent chromosomal translocations

30 September 2017

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Chromatin mobility is increased at sites of DNA double-strand breaks

30 September 2017

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Cohesin protects genes against γH2AX Induced by DNA double-strand breaks

30 September 2017

1 reference

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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

30 September 2017

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Factors determining DNA double-strand break repair pathway choice in G2 phase

30 September 2017

1 reference

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ATM limits incorrect end utilization during non-homologous end joining of multiple chromosome breaks

30 September 2017

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High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome.

30 September 2017

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53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

30 September 2017

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ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

30 September 2017

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Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin.

30 September 2017

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Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes

30 September 2017

1 reference

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Live cell microscopy analysis of radiation-induced DNA double-strand break motion.

30 September 2017

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53BP1 facilitates long-range DNA end-joining during V(D)J recombination

30 September 2017

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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin

30 September 2017

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Positional stability of single double-strand breaks in mammalian cells

30 September 2017

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Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.

30 September 2017

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Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

30 September 2017

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Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

30 September 2017

1 reference

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Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

30 September 2017

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

30 September 2017

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Complex H2AX phosphorylation patterns by multiple kinases including ATM and DNA-PK in human cells exposed to ionizing radiation and treated with kinase inhibitors

30 September 2017

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ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation

30 September 2017

1 reference

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Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

30 September 2017

1 reference

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Synapsis of DNA ends by DNA-dependent protein kinase

30 September 2017

1 reference

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

30 September 2017

1 reference

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ATM phosphorylates histone H2AX in response to DNA double-strand breaks

30 September 2017

1 reference

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Rad52 forms DNA repair and recombination centers during S phase

30 September 2017

1 reference

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The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity

30 September 2017

1 reference

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

30 September 2017

1 reference

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ATM specifically mediates repair of double-strand breaks with blocked DNA ends

30 September 2017

1 reference

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Spatial dynamics of chromosome translocations in living cells.

29 June 2018

1 reference

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γH2AX spreading linked to homology search.

29 June 2018

1 reference

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Role of ATM and the damage response mediator proteins 53BP1 and MDC1 in the maintenance of G(2)/M checkpoint arrest

29 June 2018

1 reference

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53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility

29 June 2018

1 reference

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Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.

29 June 2018

1 reference

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Control of sister chromatid recombination by histone H2AX.

29 June 2018

1 reference

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Quantifying DNA double-strand breaks induced by site-specific endonucleases in living cells by ligation-mediated purification.

29 June 2018

1 reference

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DNA-dependent protein kinase regulates DNA end resection in concert with Mre11-Rad50-Nbs1 (MRN) and ataxia telangiectasia-mutated (ATM).

22 September 2018

1 reference

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Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machinery.

22 September 2018

1 reference

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Positional stability of damaged chromatin domains along radiation tracks in mammalian cells.

22 September 2018

1 reference

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Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair.

22 September 2018

1 reference

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Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains.

22 September 2018

1 reference

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Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670905

The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4670905

Increased chromosome mobility facilitates homology search during recombination

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26586426

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Clustering of double strand break-containing chromosome domains is not inhibited by inactivation of major repair proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26586426

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELREP.2015.10.024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26586426%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26586426%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26586426%20AND%20SRC:MED&resulttype=core&format=json