PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with 177Lu-DOTA-bombesin analogues. (Q36338484)

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English	PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with 177Lu-DOTA-bombesin analogues.	scientific article

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4 February 2020

PEGylation, increasing specific activity and multiple dosing as strategies to improve the risk-benefit profile of targeted radionuclide therapy with 177Lu-DOTA-bombesin analogues (English)

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4 February 2020

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Simone Däpp

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4 February 2020

Cristina Müller

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4 February 2020

Elisa García Garayoa

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4 February 2020

Peter Bläuenstein

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4 February 2020

Veronique Maes

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4 February 2020

Luc Brans

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4 February 2020

Dirk A Tourwé

7

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publication date

9 June 2012

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EJNMMI Research

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2

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1

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4 February 2020

https://scigraph.springernature.com/pub.10.1186/2191-219x-2-24

0 references

PEGylation of (99m)Tc-labeled bombesin analogues improves their pharmacokinetic properties

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In vitro and in vivo evaluation of 64Cu-labeled SarAr-bombesin analogs in gastrin-releasing peptide receptor-expressing prostate cancer

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18F-labeled bombesin analog for specific and effective targeting of prostate tumors expressing gastrin-releasing peptide receptors.

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In vitro and in vivo characterization of novel 18F-labeled bombesin analogues for targeting GRPR-positive tumors.

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30 September 2017

A standardised study to compare prostate cancer targeting efficacy of five radiolabelled bombesin analogues

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30 September 2017

Peptide receptor imaging of prostate cancer with radiolabelled bombesin analogues

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30 September 2017

Novel glycated [99mTc(CO)3]-labeled bombesin analogues for improved targeting of gastrin-releasing peptide receptor-positive tumors

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30 September 2017

Influence of the molecular charge on the biodistribution of bombesin analogues labeled with the [99mTc(CO)3]-core

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30 September 2017

Chemical and biological characterization of new Re(CO)3/[99mTc](CO)3 bombesin analogues

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30 September 2017

Synthesis and evaluation of [18F] labeled pyrimidine nucleosides for positron emission tomography imaging of herpes simplex virus 1 thymidine kinase gene expression.

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30 September 2017

177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer.

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30 September 2017

Evaluation of combined (177)Lu-DOTA-8-AOC-BBN (7-14)NH(2) GRP receptor-targeted radiotherapy and chemotherapy in PC-3 human prostate tumor cell xenografted SCID mice

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30 September 2017

Protein PEGylation decreases observed target association rates via a dual blocking mechanism

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30 September 2017

GRP receptor-targeted PET of a rat pancreas carcinoma xenograft in nude mice with a 68Ga-labeled bombesin(6-14) analog

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30 September 2017

Overview of results of peptide receptor radionuclide therapy with 3 radiolabeled somatostatin analogs.

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30 September 2017

Renal toxicity after radionuclide therapy

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30 September 2017

Gastrin releasing peptide (GRP) receptor targeted radiopharmaceuticals: a concise update

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30 September 2017

Effect of pegylation on pharmaceuticals

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30 September 2017

[99mTc]Demobesin 1, a novel potent bombesin analogue for GRP receptor-targeted tumour imaging

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30 September 2017

A 99mTc(I)-postlabeled high affinity bombesin analogue as a potential tumor imaging agent

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30 September 2017

There are three distinct forms of bombesin. Identification of [Leu13]bombesin, [Phe13]bombesin, and [Ser3,Arg10,Phe13]bombesin in the frog Bombina orientalis

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30 September 2017

Long-term evaluation of renal toxicity after peptide receptor radionuclide therapy with 90Y-DOTATOC and 177Lu-DOTATATE: the role of associated risk factors.

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29 June 2018

68Ga-labeled bombesin studies in patients with gastrointestinal stromal tumors: comparison with 18F-FDG.

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29 June 2018

Long-term follow-up of renal function after peptide receptor radiation therapy with (90)Y-DOTA(0),Tyr(3)-octreotide and (177)Lu-DOTA(0), Tyr(3)-octreotate

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29 June 2018

Gastrin-releasing peptide receptors in non-neoplastic and neoplastic human breast

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29 June 2018

Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation.

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29 June 2018

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22 September 2018

Alpha- versus beta-particle radiopeptide therapy in a human prostate cancer model (213Bi-DOTA-PESIN and 213Bi-AMBA versus 177Lu-DOTA-PESIN).

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22 September 2018

Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks.

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22 September 2018

Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: toxicity, efficacy, and survival

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22 September 2018

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22 September 2018

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22 September 2018

Synthesis and evaluation of bombesin derivatives on the basis of pan-bombesin peptides labeled with indium-111, lutetium-177, and yttrium-90 for targeting bombesin receptor-expressing tumors

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22 September 2018

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel series of 111In-labeled bombesin analogs as potential radiopharmaceuticals for specific targeting of gastrin-releasing peptide receptors expressed on human prostate cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/22681935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A method to separate the rectum from the prostate during proton beam radiotherapy of prostate cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22681935

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/2191-219X-2-24

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4 February 2020

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4 February 2020

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4 February 2020

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