Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (Q36332978)

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English	Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein	scientific article

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scholarly article

1 reference

Europe PubMed Central

13 August 2017

Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (English)

1 reference

Europe PubMed Central

13 August 2017

ribonucleoprotein complex

1 reference

based on heuristic

inferred from title

Koen Bartholomeeusen

1

object named as

Koen Bartholomeeusen

1 reference

Europe PubMed Central

13 August 2017

Matija Boris Peterlin

4

object named as

B Matija Peterlin

1 reference

Europe PubMed Central

13 August 2017

author name string

Yanhui Xiang

2

1 reference

Europe PubMed Central

13 August 2017

Koh Fujinaga

3

1 reference

Europe PubMed Central

13 August 2017

language of work or name

0 references

publication date

5 September 2012

1 reference

Europe PubMed Central

13 August 2017

number of pages

8

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

13 August 2017

287

1 reference

Europe PubMed Central

13 August 2017

36609-36616

1 reference

Europe PubMed Central

13 August 2017

43

1 reference

Europe PubMed Central

13 August 2017

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

1 reference

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1 reference

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RNA polymerase II elongation control

1 reference

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1 reference

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30 September 2017

Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes.

1 reference

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Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation

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Targeting MYC dependence in cancer by inhibiting BET bromodomains

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Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation.

1 reference

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1 reference

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7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription

1 reference

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Human mediator subunit MED26 functions as a docking site for transcription elongation factors

1 reference

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Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation.

1 reference

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1 reference

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Selective inhibition of BET bromodomains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3476326

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The mechanism of release of P-TEFb and HEXIM1 from the 7SK snRNP by viral and cellular activators includes a conformational change in 7SK

1 reference

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HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription

1 reference

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Misguided transcriptional elongation causes mixed lineage leukemia

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Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing.

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Control of inducible gene expression by signal-dependent transcriptional elongation

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miR-198 inhibits HIV-1 gene expression and replication in monocytes and its mechanism of action appears to involve repression of cyclin T1

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1 reference

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Transcriptional interference antagonizes proviral gene expression to promote HIV latency

1 reference

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PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

1 reference

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HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription

1 reference

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Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex

1 reference

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Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR.

1 reference

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1 reference

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Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription.

1 reference

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Breaking barriers to transcription elongation

1 reference

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30 September 2017

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1 reference

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Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4

1 reference

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The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.410746

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

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