Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice. (Q36330343)

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9 March 2020

title

Silencing of lipid metabolism genes through IRE1α-mediated mRNA decay lowers plasma lipids in mice (English)

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9 March 2020

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4

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9 March 2020

Takao Iwawaki

9

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9 March 2020

Victor E. Koteliansky

7

object named as

Victor Koteliansky

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9 March 2020

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Ann-Hwee Lee

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9 March 2020

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Laurie H Glimcher

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9 March 2020

author name string

Jae-Seon So

1

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9 March 2020

Kyu Yeon Hur

2

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9 March 2020

Margarite Tarrio

3

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9 March 2020

Maria Frank-Kamenetsky

5

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9 March 2020

Kevin Fitzgerald

6

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9 March 2020

Andrew H Lichtman

8

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publication date

1 October 2012

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9 March 2020

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9 March 2020

volume

16

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9 March 2020

page(s)

487-499

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9 March 2020

issue

4

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IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

9 March 2020

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IRE1α disruption causes histological abnormality of exocrine tissues, increase of blood glucose level, and decrease of serum immunoglobulin level

30 September 2017

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Identification of a consensus element recognized and cleaved by IRE1 alpha.

30 September 2017

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The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

30 September 2017

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A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response

30 September 2017

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Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure

30 September 2017

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Lipid-like materials for low-dose, in vivo gene silencing

30 September 2017

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Modulation of plasma TG lipolysis by Angiopoietin-like proteins and GPIHBP1.

30 September 2017

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Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

30 September 2017

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IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

30 September 2017

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30 September 2017

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30 September 2017

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Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans.

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response.

30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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30 September 2017

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

30 September 2017

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30 September 2017

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30 September 2017

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Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1

30 September 2017

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Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice

30 September 2017

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Cloning of mammalian Ire1 reveals diversity in the ER stress responses

30 September 2017

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Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

30 September 2017

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A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus

30 September 2017

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The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

30 September 2017

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Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease

29 June 2018

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Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.

22 September 2018

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Involvement of endoplasmic reticulum stress in insulin resistance and diabetes

22 September 2018

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Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity

22 September 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23040070

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2012.09.004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23040070%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23040070%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23040070%20AND%20SRC:MED&resulttype=core&format=json