Glutaredoxin 1 protects dopaminergic cells by increased protein glutathionylation in experimental Parkinson's disease (Q36326552)

13 August 2017

Glutaredoxin 1 protects dopaminergic cells by increased protein glutathionylation in experimental Parkinson's disease (English)

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13 August 2017

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1 reference

Humberto Rodríguez-Rocha

object named as

Humberto Rodriguez-Rocha

1

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Rodrigo Franco

object named as

Rodrigo Franco

6

0 references

Aracely Garcia-Garcia

2

object named as

Aracely Garcia Garcia

1 reference

13 August 2017

Laura Zavala-Flores

3

1 reference

13 August 2017

Sumin Li

4

1 reference

13 August 2017

Nandakumar Madayiputhiya

5

1 reference

13 August 2017

14 September 2012

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Antioxidants & Redox Signaling

13 August 2017

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13 August 2017

17

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13 August 2017

12

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13 August 2017

1676-1693

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describes a project that uses

13 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3474191/fullTextXML

inferred from PubMed Central ID database lookup

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A disruption in iron-sulfur center biogenesis via inhibition of mitochondrial dithiol glutaredoxin 2 may contribute to mitochondrial and cellular iron dysregulation in mammalian glutathione-depleted dopaminergic cells: implications for Parkinson's d

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Parkinson's disease and residential exposure to maneb and paraquat from agricultural applications in the central valley of California

30 September 2017

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Cell death pathways in Parkinson's disease: proximal triggers, distal effectors, and final steps

30 September 2017

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30 September 2017

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Knockdown of cytosolic glutaredoxin 1 leads to loss of mitochondrial membrane potential: implication in neurodegenerative diseases

30 September 2017

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30 September 2017

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Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1

30 September 2017

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Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity

30 September 2017

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Neuromelanin selectively induces apoptosis in dopaminergic SH-SY5Y cells by deglutathionylation in mitochondria: involvement of the protein and melanin component

30 September 2017

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Oxidative and nitrative protein modifications in Parkinson's disease

30 September 2017

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Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease

30 September 2017

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30 September 2017

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Mitochondria in the aetiology and pathogenesis of Parkinson's disease

30 September 2017

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30 September 2017

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Constitutive expression and functional characterization of mitochondrial glutaredoxin (Grx2) in mouse and human brain

30 September 2017

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Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia

30 September 2017

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Epidemiologic studies of environmental exposures in Parkinson's disease

30 September 2017

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Glutathione supplementation potentiates hypoxic apoptosis by S-glutathionylation of p65-NFkappaB.

30 September 2017

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Mitochondria are a major source of paraquat-induced reactive oxygen species production in the brain

30 September 2017

1 reference

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Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy

30 September 2017

1 reference

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Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease

30 September 2017

1 reference

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Genome-wide atlas of gene expression in the adult mouse brain

30 September 2017

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Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation

30 September 2017

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Paraquat exposure as an etiological factor of Parkinson's disease

30 September 2017

1 reference

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Pesticide exposure and risk for Parkinson's disease

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Glutathionylation of mitochondrial proteins

30 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Pathogenesis of nigral cell death in Parkinson's disease

30 September 2017

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Evolution of the gelsolin family of actin-binding proteins as novel transcriptional coactivators.

30 September 2017

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POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis

30 September 2017

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Regulation of mitochondrial NADP+-dependent isocitrate dehydrogenase activity by glutathionylation

30 September 2017

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Gelsolin superfamily proteins: key regulators of cellular functions.

30 September 2017

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Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE.

30 September 2017

1 reference

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Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells

30 September 2017

1 reference

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The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Rational siRNA design for RNA interference

30 September 2017

1 reference

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Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors

30 September 2017

1 reference

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The possible physiological function of thioltransferase in cells

30 September 2017

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Stable and controllable RNA interference: Investigating the physiological function of glutathionylated actin

30 September 2017

1 reference

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Identification of S-glutathionylated cellular proteins during oxidative stress and constitutive metabolism by affinity purification and proteomic analysis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2.

30 September 2017

1 reference

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Reversible glutathionylation regulates actin polymerization in A431 cells

30 September 2017

1 reference

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Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by activating NF-kappa B via Ref-1.

30 September 2017

1 reference

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Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic neuronal cell death: role of caspases, ROS, and JNK

30 September 2017

1 reference

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Rat brain thioltransferase: regional distribution, immunological characterization, and localization by fluorescent in situ hybridization

30 September 2017

1 reference

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Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral

30 September 2017

1 reference

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A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra.

30 September 2017

1 reference

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Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease.

30 September 2017

1 reference

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Spectrin isoforms in mammalian brain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Kinetic and mechanistic characterization and versatile catalytic properties of mammalian glutaredoxin 2: implications for intracellular roles

30 September 2017

1 reference

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Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients.

29 June 2018

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Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Posttranslational modification of cysteine in redox signaling and oxidative stress: Focus on s-glutathionylation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Paraquat neurotoxicity is mediated by a Bak-dependent mechanism.

22 September 2018

1 reference

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Complex I is the major site of mitochondrial superoxide production by paraquat

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

S-glutathiolation by peroxynitrite of p21ras at cysteine-118 mediates its direct activation and downstream signaling in endothelial cells

22 September 2018

1 reference

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Actin S-glutathionylation: evidence against a thiol-disulphide exchange mechanism

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

A distinct death mechanism is induced by 1-methyl-4-phenylpyridinium or by 6-hydroxydopamine in cultured rat cortical neurons: degradation and dephosphorylation of tau.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Glutaredoxin is essential for maintenance of brain mitochondrial complex I: studies with MPTP.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Reversible S-glutathionylation of Cys 374 regulates actin filament formation by inducing structural changes in the actin molecule.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Regulation of cAMP-dependent protein kinase activity by glutathionylation.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3474191

Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons.

22 September 2018

1 reference

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Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease

22 September 2018

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12 December 2020

Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells

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12 December 2020

Oxidative damage in Parkinson's disease

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12 December 2020

Identification of oxidant-sensitive proteins: TNF-alpha induces protein glutathiolation

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12 December 2020

Production and titration of lentiviral vectors

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12 December 2020

Identifiers

DOI

10.1089/ARS.2011.4474

1 reference

13 August 2017

1 reference

13 August 2017

1 reference