Some issues with composite endpoints in clinical trials (Q36324876)

13 August 2017

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title

Some issues with composite endpoints in clinical trials (English)

1 reference

13 August 2017

George Y H Chi

1

1 reference

PubMed ID

16313272

13 August 2017

language of work or name

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1 December 2005

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Fundamental and Clinical Pharmacology

13 August 2017

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13 August 2017

19

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13 August 2017

6

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13 August 2017

609-619

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Mirtazapine orally disintegrating tablet versus sertraline: a prospective onset of action study

13 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

A Double-Blind, Randomized, Placebo-Controlled Trial of Olanzapine in the Prevention of Psychotic Relapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Antidepressant properties of anticonvulsant drugs for bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

End points and United States Food and Drug Administration approval of oncology drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Increasing burden of treatment in the acute coronary syndromes: is it justified?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Low molecular weight heparin in acute coronary syndrome: evidence for superior or equivalent efficacy compared with unfractionated heparin?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Comparison of low-molecular-weight heparin with unfractionated heparin acutely and with placebo for 6 weeks in the management of unstable coronary artery disease. Fragmin in unstable coronary artery disease study (FRIC)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Enoxaparin prevents death and cardiac ischemic events in unstable angina/non-Q-wave myocardial infarction. Results of the thrombolysis in myocardial infarction (TIMI) 11B trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Inhibition of platelet glycoprotein IIb/IIIa with eptifibatide in patients with acute coronary syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Effect of fluvastatin on cardiac outcomes in renal transplant recipients: a multicentre, randomised, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Monitoring mortality at interim analyses while testing a composite endpoint at the final analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Combined endpoints: can we use them?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Clinical perspectives on the use of composite endpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Clinical trials with multiple outcomes: a statistical perspective on their design, analysis, and interpretation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Commentary on 'Alpha calculus in clinical trials: considerations and commentary for the new millennium'.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

Morbidity and mortality in patients randomised to double-blind treatment with a long-acting calcium-channel blocker or diuretic in the International Nifedipine GITS study: Intervention as a Goal in Hypertension Treatment (INSIGHT).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2005.00370.X

10.1111/J.1472-8206.2005.00370.X

21 January 2018

Identifiers

DOI

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release_3k6dxcs5vrh3jhn6crxbu2hkf4

13 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/3k6dxcs5vrh3jhn6crxbu2hkf4

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24 November 2022

based on heuristic

PubMed ID

16313272

1 reference

PubMed ID

16313272