Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity (Q36321491)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19701246%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity (English)

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6 February 2020

1 reference

3

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6 February 2020

Anna Sparatore

4

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6 February 2020

David D Roberts

8

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6 February 2020

author name string

C H Switzer

1

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6 February 2020

L A Ridnour

2

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6 February 2020

P Del Soldato

5

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6 February 2020

T W Moody

6

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6 February 2020

M P Vitek

7

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D A Wink

9

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language of work or name

English

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publication date

24 August 2009

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6 February 2020

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6 February 2020

volume

28

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issue

43

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6 February 2020

page(s)

3837-3846

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describes a project that uses

6 February 2020

ImageQuant

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11 June 2022

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based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/onc.2009.244

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cites work

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Metastasis and AKT activation

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Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway

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30 September 2017

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Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway

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Sphingosine and its analog, the immunosuppressant 2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol, interact with the CB1 cannabinoid receptor

30 September 2017

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Integrin-linked kinase activity is associated with interleukin-1 alpha-induced progressive behavior of pancreatic cancer and poor patient survival

30 September 2017

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Nrf2 as a novel molecular target for chemoprevention

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Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes

30 September 2017

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Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol

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The role of integrin-linked kinase (ILK) in cancer progression

30 September 2017

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A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

30 September 2017

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Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

30 September 2017

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

30 September 2017

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30 September 2017

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Protein phosphatase 2A forms a molecular complex with Shc and regulates Shc tyrosine phosphorylation and downstream mitogenic signaling

30 September 2017

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Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes

30 September 2017

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30 September 2017

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

30 September 2017

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Modulation of Akt kinase activity by binding to Hsp90

30 September 2017

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Treatment of xerostomia with the bile secretion-stimulating drug anethole trithione: a clinical trial

30 September 2017

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Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

30 September 2017

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Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

30 September 2017

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Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

30 September 2017

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29 June 2018

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Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity

22 September 2018

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

22 September 2018

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A randomized phase IIb trial of anethole dithiolethione in smokers with bronchial dysplasia

22 September 2018

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Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.

22 September 2018

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The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation

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In vivo radioprotective effects of oltipraz in gamma-irradiated mice

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Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney

31 March 2020

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Selection of Protein Phosphatase 2A Regulatory Subunits Is Mediated by the C Terminus of the Catalytic Subunit

31 March 2020

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Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.

31 March 2020

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Endostatin influences endothelial morphology via the activated ERK1/2-kinase endothelial morphology and signal transduction

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31 March 2020

Identifiers

DOI

10.1038/ONC.2009.244

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19701246%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19701246%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

19701246

1 reference