Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke (Q36319554)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22632606%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Preclinical safety and pharmacokinetic profile of 3K3A-APC, a novel, modified activated protein C for ischemic stroke (English)

1 reference

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2 February 2020

1 reference

1 reference

3

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2 February 2020

author name string

Patricia D Williams

1

1 reference

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2 February 2020

Berislav V Zlokovic

2

1 reference

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2 February 2020

Kent E Pryor

4

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2 February 2020

Thomas P Davis

5

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2 February 2020

publication date

1 January 2012

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Current Pharmaceutical Design

2 February 2020

published in

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2 February 2020

volume

18

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2 February 2020

issue

27

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2 February 2020

page(s)

4215-4222

1 reference

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Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

2 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

From bench to bedside: a review of the clinical trial development plan of drotrecogin alfa (activated).

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

The cytoprotective protein C pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease-activated receptor-1 and endothelial cell protein C receptor

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Efficacy and safety of recombinant human activated protein C for severe sepsis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Functional recovery after embolic stroke in rodents by activated protein C.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Tissue plasminogen activator neurovascular toxicity is controlled by activated protein C.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Molecular characterization of an extended binding site for coagulation factor Va in the positive exosite of activated protein C.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3472038

The long-term effects of pre-treatment with activated protein C in a rat model of compression-induced spinal cord injury

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22632606

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.2174/138161212802430413

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22632606%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

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2 February 2020

PubMed publication ID

22632606

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22632606%20AND%20SRC:MED&resulttype=core&format=json