Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation (Q36317256)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23071152%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

title

Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation (English)

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15 February 2020

1

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15 February 2020

Debasis Patnaik

4

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15 February 2020

Gary J. Gorbsky

6

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15 February 2020

Jonathan Higgins

7

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15 February 2020

author name string

Natalia P Ulyanova

2

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15 February 2020

John R Daum

3

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15 February 2020

Anna V Kateneva

5

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15 February 2020

language of work or name

English

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publication date

1 October 2012

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15 February 2020

published in

Journal of Cell Biology

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15 February 2020

volume

199

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15 February 2020

issue

2

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15 February 2020

page(s)

251-268

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describes a project that uses

15 February 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3471242/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B

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A conserved role for COMA/CENP-H/I/N kinetochore proteins in the spindle checkpoint.

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Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres

30 September 2017

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CLASPs prevent irreversible multipolarity by ensuring spindle-pole resistance to traction forces during chromosome alignment.

30 September 2017

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Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.

30 September 2017

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Phosphorylation at serine 331 is required for Aurora B activation.

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Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient.

30 September 2017

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Uncoordinated loss of chromatid cohesion is a common outcome of extended metaphase arrest

30 September 2017

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Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin

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Feedback control in sensing chromosome biorientation by the Aurora B kinase.

30 September 2017

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A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis

30 September 2017

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Cohesion fatigue induces chromatid separation in cells delayed at metaphase

30 September 2017

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Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis.

30 September 2017

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Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction

30 September 2017

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Temporal changes in Hec1 phosphorylation control kinetochore-microtubule attachment stability during mitosis

30 September 2017

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Shared and separate functions of polo-like kinases and aurora kinases in cancer

30 September 2017

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Survivin reads phosphorylated histone H3 threonine 3 to activate the mitotic kinase Aurora B.

30 September 2017

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Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis

30 September 2017

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Dual detection of chromosomes and microtubules by the chromosomal passenger complex drives spindle assembly

30 September 2017

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Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.

30 September 2017

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Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface

30 September 2017

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INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization

30 September 2017

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Structure and functional characterization of the atypical human kinase haspin

30 September 2017

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Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion

30 September 2017

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Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments

30 September 2017

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30 September 2017

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Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay

30 September 2017

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The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells

30 September 2017

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Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly

30 September 2017

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Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation

30 September 2017

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30 September 2017

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MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover

30 September 2017

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30 September 2017

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The chromosomal passenger complex controls spindle checkpoint function independent from its role in correcting microtubule kinetochore interactions

30 September 2017

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Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores.

30 September 2017

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The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

30 September 2017

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Kinetochore microtubule dynamics and attachment stability are regulated by Hec1

30 September 2017

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Regulation of mitotic chromosome cohesion by Haspin and Aurora B.

30 September 2017

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Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint

30 September 2017

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The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores

30 September 2017

1 reference

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30 September 2017

1 reference

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The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment

30 September 2017

1 reference

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30 September 2017

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Aurora B regulates MCAK at the mitotic centromere

30 September 2017

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30 September 2017

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Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

30 September 2017

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The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

30 September 2017

1 reference

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The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity

30 September 2017

1 reference

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Rapid exchange of mammalian topoisomerase II alpha at kinetochores and chromosome arms in mitosis

30 September 2017

1 reference

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Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Pole-to-chromosome movements induced at metaphase: sites of microtubule disassembly

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

A dual role for Bub1 in the spindle checkpoint and chromosome congression

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Anaphase onset and dephosphorylation of mitotic phosphoproteins occur concomitantly

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

A general framework for inhibitor resistance in protein kinases.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Two histone marks establish the inner centromere and chromosome bi-orientation

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Centromere localization of INCENP-Aurora B is sufficient to support spindle checkpoint function

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

A novel protein phosphatase 1-dependent spindle checkpoint silencing mechanism

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Validating Aurora B as an anti-cancer drug target.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3471242

Driving the cell cycle with a minimal CDK control network

22 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083%2FJCB.201205106

S. pombe aurora kinase/survivin is required for chromosome condensation and the spindle checkpoint attachment response

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23071152

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.201205106

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23071152%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23071152%20AND%20SRC:MED&resulttype=core&format=json

15 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23071152%20AND%20SRC:MED&resulttype=core&format=json