Mechanisms of disease: beta-adrenergic receptors--alterations in signal transduction and pharmacogenomics in heart failure (Q36304375)

13 August 2017

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title

Mechanisms of disease: beta-adrenergic receptors--alterations in signal transduction and pharmacogenomics in heart failure (English)

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13 August 2017

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Cynthia A Carnes

2

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William T Abraham

series ordinal

3

object named as

William T Abraham

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13 August 2017

David S Feldman

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PubMed ID

16265588

13 August 2017

Michael R Bristow

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4

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13 August 2017

1 September 2005

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13 August 2017

9

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Nature Clinical Practice Cardiovascular Medicine

inferred from page(s)

published in

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13 August 2017

2

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13 August 2017

9

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13 August 2017

475-483

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Catecholamines, cardiac beta-adrenergic receptors, and heart failure

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Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure

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beta-adrenergic receptor blockade in chronic heart failure

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A comparative analysis of the results from 4 trials of beta-blocker therapy for heart failure: BEST, CIBIS-II, MERIT-HF, and COPERNICUS.

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Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice

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Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heart

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Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus

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What is the role of beta-adrenergic signaling in heart failure?

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Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

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PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

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Cardiac HCN channels: structure, function, and modulation

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The effects of norepinephrine on myocardial biology: implications for the therapy of heart failure

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Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart

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Protein kinase C switches the Raf kinase inhibitor from Raf-1 to GRK-2

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G protein-coupled receptor kinase 2--a feedback regulator of Gq pathway signalling

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Genetic manipulation of myocardial beta-adrenergic receptor activation and desensitization

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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.

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Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor

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Recent advances in cardiac beta(2)-adrenergic signal transduction

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'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors

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Mechanisms of beta-adrenergic receptor desensitization: from molecular biology to heart failure

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G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.

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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

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Adrenergic regulation of cardiac myocyte apoptosis

1 reference

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Linkage of beta1-adrenergic stimulation to apoptotic heart cell death through protein kinase A-independent activation of Ca2+/calmodulin kinase II.

1 reference

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7 January 2021

Adrenergic effects on the biology of the adult mammalian cardiocyte

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Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis : role of a pertussis toxin-sensitive G protein

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β1 integrins expression in adult rat ventricular myocytes and its role in the regulation of β‐adrenergic receptor‐stimulated apoptosis

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G-proteins in growth and apoptosis: lessons from the heart

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Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents

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Phospholamban: a promising therapeutic target in heart failure?

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Manipulating cardiac contractility in heart failure: data from mice and men.

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Decoding calcium signals involved in cardiac growth and function

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Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytes

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Predictors of lack of response to resynchronization therapy.

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Cardiac Resynchronization Therapy for Advanced Heart Failure

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Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment

1 reference

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Increased frequency of cytochrome P450 2D6 poor metabolizers among patients with metoprolol-associated adverse effects

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Pharmacogenomics of heart failure -- focus on drug disposition and action

1 reference

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beta-Adrenergic receptor polymorphisms and responses during titration of metoprolol controlled release/extended release in heart failure.

1 reference

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Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness

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Physiological significance of beta-adrenergic receptor polymorphisms: in-vivo or in-vitro veritas?

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A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

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Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure

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Pharmacology and physiology of human adrenergic receptor polymorphisms

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A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure

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Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice

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The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure

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Selective versus nonselective beta-blockade for heart failure therapy: are there lessons to be learned from the COMET trial?

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Effect of baseline or changes in adrenergic activity on clinical outcomes in the beta-blocker evaluation of survival trial.

1 reference

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7 January 2021

Different intrinsic activities of bucindolol, carvedilol and metoprolol in human failing myocardium

1 reference

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Polymorphisms of beta-adrenergic receptors in heart failure

1 reference

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7 January 2021

β1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure

1 reference

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7 January 2021

Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to beta-blocker therapy

1 reference

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7 January 2021

Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure

1 reference

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7 January 2021

An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study

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Inotropes and beta-blockers: is there a need for new guidelines?

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7 January 2021

Identifiers

DOI

10.1038/NCPCARDIO0309

1 reference

13 August 2017

1 reference

PubMed ID

16265588