Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia (Q36303697)

13 August 2017

Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia (English)

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13 August 2017

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Baozhi Yuan

1

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13 August 2017

Masanori Takaiwa

2

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13 August 2017

Thomas L Clemens

3

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13 August 2017

Jian Q Feng

4

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13 August 2017

Rajiv Kumar

5

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13 August 2017

Peter S Rowe

6

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13 August 2017

Yixia Xie

7

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13 August 2017

Marc K Drezner

8

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13 August 2017

language of work or name

English

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publication date

1 February 2008

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Journal of Clinical Investigation

13 August 2017

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13 August 2017

118

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13 August 2017

2

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13 August 2017

722-734

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describes a project that uses

13 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2157563/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.

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Serum MEPE-ASARM-peptides are elevated in X-linked rickets (HYP): implications for phosphaturia and rickets

30 September 2017

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Fibroblast growth factor 7: an inhibitor of phosphate transport derived from oncogenic osteomalacia-causing tumors

30 September 2017

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MEPE has the properties of an osteoblastic phosphatonin and minhibin.

30 September 2017

1 reference

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Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent

30 September 2017

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New insights into phosphate homeostasis: fibroblast growth factor 23 and frizzled-related protein-4 are phosphaturic factors derived from tumors associated with osteomalacia

30 September 2017

1 reference

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Fibroblast growth factor-23 is the phosphaturic factor in tumor-induced osteomalacia and may be phosphatonin

30 September 2017

1 reference

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Ontogeny of Phex/PHEX protein expression in mouse embryo and subcellular localization in osteoblasts

30 September 2017

1 reference

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Effects of PHEX antisense in human osteoblast cells

30 September 2017

1 reference

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Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Mepe, the gene encoding a tumor-secreted protein in oncogenic hypophosphatemic osteomalacia, is expressed in bone

30 September 2017

1 reference

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FGF-23 inhibits renal tubular phosphate transport and is a PHEX substrate

30 September 2017

1 reference

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Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase

30 September 2017

1 reference

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Intrinsic mineralization defect in Hyp mouse osteoblasts

30 September 2017

1 reference

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The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

30 September 2017

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Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets

30 September 2017

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Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP).

30 September 2017

1 reference

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Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice

30 September 2017

1 reference

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Recent advances in gene mutagenesis by site-directed recombination

30 September 2017

1 reference

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Inducible gene targeting in mice

30 September 2017

1 reference

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Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect

30 September 2017

1 reference

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cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone

30 September 2017

1 reference

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Infertility in male transgenic mice: disruption of sperm development by HSV-tk expression in postmeiotic germ cells

29 June 2018

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Characterization of the defect in the Na(+)-phosphate transporter in vitamin D-resistant hypophosphatemic mice

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Defective bone formation by hyp mouse bone cells transplanted into normal mice: Evidence in favor of an intrinsic osteoblast defect

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

The defect in transcellular transport of phosphate in the nephron is located in brush-border membranes in X-linked hypophosphatemia (Hyp mouse model)

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

A rapid method for the isolation of kidney brush border membranes

29 June 2018

1 reference

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Pathogenic role of Fgf23 in Hyp mice.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Evidence for abnormal translational regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase activity in the hyp-mouse

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Mutant FGF-23 responsible for autosomal dominant hypophosphatemic rickets is resistant to proteolytic cleavage and causes hypophosphatemia in vivo.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

The effects of bone marrow transplantation on X-linked hypophosphatemic mice.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in the human kidney.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Location of crossovers during gene targeting with insertion and replacement vectors

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2157563

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization

22 September 2018

1 reference

12 December 2020

A microassay for 1,25-dihydroxyvitamin D not requiring high performance liquid chromatography: application to clinical studies

1 reference

12 December 2020

Cultured osteoblasts from normal and hypophosphatemic mice: calcitriol receptors and biological response to the hormone

1 reference

12 December 2020

Effect of dietary phosphate deprivation and supplementation of recipient mice on bone formation by transplanted cells from normal and X‐linked hypophosphatemic mice

1 reference

12 December 2020

Gene targeting in embryonic stem cells

1 reference

12 December 2020

Tumor-induced osteomalacia--unveiling a new hormone

1 reference

12 December 2020

X-linked hypophosphatemic rickets and the murine Hyp homologue

1 reference

12 December 2020

Pex mRNA is localized in developing mouse osteoblasts and odontoblasts

1 reference

12 December 2020

Mutational analysis of PHEX gene in X-linked hypophosphatemia

1 reference

12 December 2020

Direct removal in the mouse of a floxed neo gene from a three-loxP conditional knockout allele by two novel approaches

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI32702

1 reference

13 August 2017

1 reference

13 August 2017

1 reference