Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases (Q36289023)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

title

Odanacatib, A Cathepsin K-Specific Inhibitor, Inhibits Inflammation and Bone Loss Caused by Periodontal Diseases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

0 references

1

1 reference

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5 March 2020

author name string

Jianwei Chen

2

1 reference

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5 March 2020

Zheng Zhu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Michael S Reddy

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

John D Mountz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Wei Chen

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Yi-Ping Li

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

language of work or name

English

0 references

publication date

16 April 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

Journal of Periodontology

5 March 2020

published in

1 reference

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5 March 2020

volume

86

1 reference

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5 March 2020

issue

8

1 reference

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5 March 2020

page(s)

972-983

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

TLR2 promoter hypermethylation creates innate immune dysbiosis

5 March 2020

cites work

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Cbfβ deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbfβ required for skeletal development.

30 September 2017

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Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction

30 September 2017

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Periodontopathogen profile of healthy and oral lichen planus patients with gingivitis or periodontitis

30 September 2017

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C/EBPα regulates osteoclast lineage commitment

30 September 2017

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RNAi-mediated silencing of Atp6i and Atp6i haploinsufficiency prevents both bone loss and inflammation in a mouse model of periodontal disease

30 September 2017

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Activation of invariant NK T cells in periodontitis lesions

30 September 2017

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Cathepsin-mediated necrosis controls the adaptive immune response by Th2 (T helper type 2)-associated adjuvants

30 September 2017

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RNA interference-mediated silencing of Atp6i prevents both periapical bone erosion and inflammation in the mouse model of endodontic disease

30 September 2017

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Inhibiting periapical lesions through AAV-RNAi silencing of cathepsin K.

30 September 2017

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Identification, characterization, and isolation of a common progenitor for osteoclasts, macrophages, and dendritic cells from murine bone marrow and periphery

30 September 2017

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Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function

30 September 2017

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Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

30 September 2017

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Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey

30 September 2017

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Toll-like receptors and their dual role in periodontitis: a review

30 September 2017

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Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues

30 September 2017

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The role of bacterial biofilm in persistent infections and control strategies

30 September 2017

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Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

30 September 2017

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Cathepsins and their involvement in immune responses

30 September 2017

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Bisphosphonates cause osteonecrosis of the jaw-like disease in mice

30 September 2017

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Taking a toll on the bones: regulation of bone metabolism by innate immune regulators

30 September 2017

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Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence

30 September 2017

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Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease

30 September 2017

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Interleukin-6 and chronic inflammation

30 September 2017

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Cysteine cathepsins in the immune response

30 September 2017

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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

30 September 2017

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Macrophages in periapical lesions

30 September 2017

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TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

30 September 2017

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30 September 2017

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Progression of chronic periodontitis can be predicted by the levels of Porphyromonas gingivalis and Treponema denticola in subgingival plaque.

30 September 2017

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29 June 2018

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29 June 2018

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29 June 2018

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22 September 2018

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Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies.

22 September 2018

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Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts

22 September 2018

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T cell response mediated by myeloid cell-derived IL-12 is responsible for Porphyromonas gingivalis-induced periodontitis in IL-10-deficient mice

22 September 2018

1 reference

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The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss.

22 September 2018

1 reference

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Oral infection with a periodontal pathogen accelerates early atherosclerosis in apolipoprotein E-null mice

22 September 2018

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Relationship between rheumatoid arthritis and periodontitis.

22 September 2018

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Human osteoclast cathepsin K is processed intracellularly prior to attachment and bone resorption

22 September 2018

1 reference

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Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

22 September 2018

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Crossref

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Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect

21 January 2018

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Crossref

https://api.crossref.org/works/10.1902%2FJOP.2015.140643

IL-10, but not IL-4, suppresses infection-stimulated bone resorption in vivo

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25879791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Immunology. The toll of cathepsin K deficiency

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25879791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Characterization of mouse cathepsin K gene, the gene promoter, and the gene expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25879791

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1902/JOP.2015.140643

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25879791%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference