Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease (Q36284342)

13 August 2017

Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease (English)

1 reference

13 August 2017

0 references

L Geng

1

1 reference

13 August 2017

M Solimena

2

1 reference

13 August 2017

R A Flavell

3

1 reference

13 August 2017

R S Sherwin

4

1 reference

13 August 2017

A C Hayday

5

1 reference

13 August 2017

language of work or name

English

0 references

publication date

1 August 1998

1 reference

Proceedings of the National Academy of Sciences of the United States of America

13 August 2017

1 reference

13 August 2017

95

1 reference

13 August 2017

17

1 reference

13 August 2017

10055-10060

1 reference

Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice

13 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

A mechanism for the major histocompatibility complex-linked resistance to autoimmunity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

The thymus and self-tolerance: co-existence of encephalitogenic S100 beta-specific T cells and their nominal autoantigen in the normal adult rat thymus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

The shaping of the brain-specific T lymphocyte repertoire in the thymus.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Infection, autoimmunity and autoimmune disease.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Association of GAD-65, but not of GAD-67, with the Golgi complex of transfected Chinese hamster ovary cells mediated by the N-terminal region

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

A dominant-negative transgene defines a role for p56lck in thymopoiesis

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Non-genetic risk determinants of type 1 diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Genetic control of autoimmune diabetes in the NOD mouse

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Genetic analysis of type 1 diabetes using whole genome approaches

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. I. Its general distribution in synapses of the central and peripheral nervous system demonstrated by immunofluorescence in frozen and plastic sections

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Introns increase transcriptional efficiency in transgenic mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Pathogenesis of myasthenia gravis. Acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Transgenic mouse models of self-tolerance and autoreactivity by the immune system

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Autoantibodies to GABA-ergic neurons and pancreatic beta cells in stiff-man syndrome

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

An overview on possible mechanisms of destruction of the insulin-producing beta cell

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Two genes encode distinct glutamate decarboxylases

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Sex steroids, glucocorticoids, stress and autoimmunity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Autoimmunity to glutamic acid decarboxylase (GAD) in stiffman syndrome and insulin-dependent diabetes mellitus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Co-segregation of a gene encoding a deletion ligand for Tcrb-V3+ T cells with Mtv-3.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Islet cell antigens in insulin-dependent diabetes: Pandora's box revisited

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

The murine autoimmune diabetes model: NOD and related strains

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

In vivo and in vitro clonal deletion of double-positive thymocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

T cell autoreactivity to insulin in diabetic and related non-diabetic individuals

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Identification of immunogenic epitopes of GAD 65 presented by Ag7 in non-obese diabetic mice

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Late complications of immune deviation therapy in a nonhuman primate

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Genetic control of giant perivascular space formation in the thymus of NOD mice.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Antigen compartmentation and T helper cell tolerance induction

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Identification of a dominant epitope of glutamic acid decarboxylase (GAD-65) recognized by autoantibodies in stiff-man syndrome

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Localization and quantitation of expression of two glutamate decarboxylase genes in pancreatic beta-cells and other peripheral tissues of mouse and rat.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Prevention of overt diabetes and insulitis by intrathymic injection of syngeneic islets in newborn nonobese diabetic (NOD) mice

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Positive and negative selection of an antigen receptor on T cells in transgenic mice.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

A general method for rapid site-directed mutagenesis using the polymerase chain reaction.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Ablation of "tolerance" and induction of diabetes by virus infection in viral antigen transgenic mice

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

The chymotryptic phosphopyridoxyl peptide of DOPA decarboxylase from pig kidney

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=21460

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

29 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Effect of 5-alpha dihydrotestosterone on T-cell proliferation of the female nonobese diabetic mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

T cell tolerance by clonal elimination in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Autoimmune diabetes as a consequence of locally produced interleukin-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Revelation of specificity of 64K autoantibodies in IDDM serums by high-resolution 2-D gel electrophoresis. Unambiguous identification of 64K target antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Autoantibodies in nonobese diabetic mice immunoprecipitate 64,000-Mr islet antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Transgenic plants expressing autoantigens fed to mice to induce oral immune tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Levels of peripheral T cell tolerance induced by different doses of tolerogen

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Inherent β-Cell Dysfunction Induced by Transgenic Expression of Allogeneic Major Histocompatibility Complex Class I Antigen in Islet Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Organ-specific disease provoked by systemic autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Following a diabetogenic T cell from genesis through pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate beta-cell antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Prevention of autoimmune diabetes in the BB rat by intrathymic islet transplantation at birth

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Quantitation of glutamic acid decarboxylase autoantibody levels in prospectively evaluated relatives of patients with type I diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.95.17.10055

21 January 2018

Identifiers

DOI

10.1073/PNAS.95.17.10055

1 reference

13 August 2017

0 references

1 reference

13 August 2017

1 reference