Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult (Q36278646)

13 August 2017

Transgenic APP expression during postnatal development causes persistent locomotor hyperactivity in the adult (English)

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13 August 2017

Shaefali P Rodgers

1

1 reference

13 August 2017

Heather A Born

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2

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13 August 2017

Pritam Das

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3

1 reference

13 August 2017

Joanna L Jankowsky

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4

1 reference

13 August 2017

18 June 2012

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Molecular Neurodegeneration

13 August 2017

1 reference

13 August 2017

7

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13 August 2017

28

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https://scigraph.springernature.com/pub.10.1186/1750-1326-7-28

13 August 2017

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cites work

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Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy

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The upside of APP at synapses

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Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease

30 September 2017

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Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.

30 September 2017

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Amyloid plaque and neurofibrillary tangle pathology in a regulatable mouse model of Alzheimer's disease

30 September 2017

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Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1.

30 September 2017

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Behavioral phenotyping strategies for mutant mice

30 September 2017

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Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice

30 September 2017

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Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

30 September 2017

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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

30 September 2017

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beta-Secretase, APP and Abeta in Alzheimer's disease.

30 September 2017

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Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2

30 September 2017

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Molecular genetics of Alzheimer's disease.

30 September 2017

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Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

30 September 2017

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Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

30 September 2017

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Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene

30 September 2017

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Control of memory formation through regulated expression of a CaMKII transgene

30 September 2017

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

30 September 2017

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

30 September 2017

1 reference

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Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

30 September 2017

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

30 September 2017

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Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

30 September 2017

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Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes

29 June 2018

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Thigmotaxis as a test for anxiolytic activity in rats.

29 June 2018

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PDGF B-chain in neurons of the central nervous system, posterior pituitary, and in a transgenic model

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Medium spiny neurons of the neostriatal matrix exhibit specific, stereotyped changes in dendritic arborization during a critical developmental period in mice.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease.

22 September 2018

1 reference

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Increased aggression in males in transgenic Tg2576 mouse model of Alzheimer's disease.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Characterization of the 3xTg-AD mouse model of Alzheimer's disease: part 1. Circadian changes.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

FAD-mutation of APP is associated with a loss of its synaptotrophic activity.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Dopamine release in prefrontal cortex in response to beta-amyloid activation of alpha7 * nicotinic receptors

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Soluble amyloid beta1-42 reduces dopamine levels in rat prefrontal cortex: relationship to nitric oxide.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Activity changes and marked stereotypic behavior precede Abeta pathology in TgCRND8 Alzheimer mice

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Age-dependent cognitive decline in the APP23 model precedes amyloid deposition.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Characterization of transgene expression and Cre recombinase activity in a panel of Thy-1 promoter-Cre transgenic mice.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Transgenic calmodulin-dependent protein kinase II activation: dose-dependent effects on synaptic plasticity, learning, and memory.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Early-onset amyloid deposition and cognitive deficits in transgenic mice expressing a double mutant form of amyloid precursor protein 695.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Behavioral disturbances without amyloid deposits in mice overexpressing human amyloid precursor protein with Flemish (A692G) or Dutch (E693Q) mutation.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Behavioral disturbances in transgenic mice overexpressing the V717F beta-amyloid precursor protein.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Developmental expression of the CaM kinase II isoforms: ubiquitous gamma- and delta-CaM kinase II are the early isoforms and most abundant in the developing nervous system.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Aggressive behaviour in transgenic mice expressing APP is alleviated by serotonergic drugs.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3457908

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

22 September 2018

1 reference

12 December 2020

Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner

1 reference

12 December 2020

Altered circadian locomotor activity in APP23 mice: a model for BPSD disturbances

1 reference

12 December 2020

Aggressive male APP23 mice modeling behavioral alterations in dementia

1 reference

12 December 2020

Identifiers

DOI

10.1186/1750-1326-7-28

1 reference

Dimensions Publication ID

13 August 2017

0 references

1 reference

13 August 2017

1 reference