A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self. (Q36275699)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22921379%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

A broad range of self-reactivity drives thymic regulatory T cell selection to limit responses to self (English)

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12 February 2020

2

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12 February 2020

Chyi-Song Hsieh

5

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12 February 2020

author name string

Hyang-Mi Lee

1

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12 February 2020

James F Mohan

4

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12 February 2020

James Scott-Browne

3

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12 February 2020

language of work or name

English

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publication date

23 August 2012

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12 February 2020

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12 February 2020

volume

37

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12 February 2020

issue

3

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12 February 2020

page(s)

475-486

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Evolutionarily conserved features contribute to αβ T cell receptor specificity

12 February 2020

cites work

1 reference

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Peripheral education of the immune system by colonic commensal microbiota.

30 September 2017

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CD4⁺CD25⁺Foxp3⁺ regulatory T cell formation requires more specific recognition of a self-peptide than thymocyte deletion

30 September 2017

1 reference

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Quantitative impact of thymic selection on Foxp3+ and Foxp3- subsets of self-peptide/MHC class II-specific CD4+ T cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

30 September 2017

1 reference

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TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

30 September 2017

1 reference

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Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated mice

30 September 2017

1 reference

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Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell tolerance

30 September 2017

1 reference

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CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms

30 September 2017

1 reference

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Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell induction

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Central tolerance: what have we learned from mice?

30 September 2017

1 reference

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DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

A two-step process for thymic regulatory T cell development.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Regulatory T cell lineage specification by the forkhead transcription factor foxp3

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3456990

Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

30 September 2017

1 reference

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Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance

30 September 2017

1 reference

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Constitutive class I-restricted exogenous presentation of self antigens in vivo

30 September 2017

1 reference

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Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells

30 September 2017

1 reference

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A kinetic basis for T cell receptor repertoire selection during an immune response

29 June 2018

1 reference

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Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes.

29 June 2018

1 reference

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V beta 5+ T cell receptors skew toward OVA+H-2Kb recognition

29 June 2018

1 reference

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Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

22 September 2018

1 reference

12 December 2020

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

12 December 2020

Origin of regulatory T cells with known specificity for antigen

1 reference

12 December 2020

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors

1 reference

12 December 2020

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1 reference

12 December 2020

Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper

1 reference

12 December 2020

10.1016/J.IMMUNI.2012.07.009

Identifiers

DOI

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12 February 2020

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12 February 2020

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