Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling (Q36269317)

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English	Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling	scientific article

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scholarly article

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

Basal forebrain cholinergic dysfunction in Alzheimer's disease--interrelationship with beta-amyloid, inflammation and neurotrophin signaling (English)

1 reference

Europe PubMed Central

13 August 2017

Alzheimer's disease

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author name string

Reinhard Schliebs

1

1 reference

Europe PubMed Central

13 August 2017

publication date

1 June 2005

1 reference

Europe PubMed Central

13 August 2017

Neurochemical Research

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Europe PubMed Central

13 August 2017

30

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Europe PubMed Central

13 August 2017

6-7

1 reference

Europe PubMed Central

13 August 2017

895-908

1 reference

Europe PubMed Central

13 August 2017

https://scigraph.springernature.com/pub.10.1007/s11064-005-6962-9

0 references

Acetylcholinesterase-Abeta complexes are more toxic than Abeta fibrils in rat hippocampus: effect on rat beta-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss

1 reference

https://api.crossref.org/works/10.1007%2FS11064-005-6962-9

21 January 2018

Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11064-005-6962-9

21 January 2018

Mechanisms of beta-amyloid neurotoxicity: perspectives of pharmacotherapy

1 reference

https://api.crossref.org/works/10.1007%2FS11064-005-6962-9

21 January 2018

Stable beta-secretase activity and presynaptic cholinergic markers during progressive central nervous system amyloidogenesis in Tg2576 mice

1 reference

https://api.crossref.org/works/10.1007%2FS11064-005-6962-9

21 January 2018

The cholinergic deficit coincides with Abeta deposition at the earliest histopathologic stages of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1007%2FS11064-005-6962-9

21 January 2018

New trends in the design of drugs against Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS11064-005-6962-9

21 January 2018

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase promotes beta-amyloid plaques in cerebral cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid-induced cholinergic denervation correlates with enhanced nitric oxide synthase activity in rat cerebral cortex: reversal by NMDA receptor blockade.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine inhibits amyloid formation by the beta-peptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic activity and amyloid precursor protein processing in aging and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combination therapy in Alzheimer's disease: a review of current evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degeneration of beta-amyloid-associated cholinergic structures in transgenic APP SW mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein kinase C inhibits cellular production of the amyloid beta-protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha7-nicotinic acetylcholine receptors mediate an Abeta(1-42)-induced increase in the level of acetylcholinesterase in primary cortical neurones.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase promotes the aggregation of amyloid-beta-peptide fragments by forming a complex with the growing fibrils.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracerebroventricular infusion of nerve growth factor in three patients with Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid(1-42) peptide directly modulates nicotinic receptors in the rat hippocampal slice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The impact of Aβ-plaques on cortical cholinergic and non-cholinergic presynaptic boutons in alzheimer's disease-like transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroreceptor changes in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cholinergic neuronal phenotype in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction during amyloid-beta-peptide neurotoxicity: role in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta(1-42) peptide alters the gating of human and mouse alpha-bungarotoxin-sensitive nicotinic receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitors: new roles and therapeutic alternatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of p75 neurotrophin receptor in the neurotoxicity by beta-amyloid peptides and synergistic effect of inflammatory cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of cholinesterase inhibitors on the secretion of beta-amyloid precursor protein in cell cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the low-affinity nerve growth factor receptor enhances beta-amyloid peptide toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid beta-protein of Alzheimer's disease increases acetylcholinesterase expression by increasing intracellular calcium in embryonal carcinoma P19 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated secretion of beta-amyloid precursor protein in rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NGF level of is not decreased in the serum, brain-spinal fluid, hippocampus, or parietal cortex of individuals with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal-induced death of neuronal PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NGF promotes amyloid precursor protein secretion via muscarinic receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-Methyl-D-aspartate receptor antagonist MK-801 and radical scavengers protect cholinergic nucleus basalis neurons against beta-amyloid neurotoxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of amyloid precursor protein processing.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intraparenchymal NGF infusions rescue degenerating cholinergic neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokines in neuroinflammation and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of amyloid precursor protein metabolism by cholinergic mechanisms and neurotrophin receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective killing of cholinergic neurons by microglial activation in basal forebrain mixed neuronal/glial cultures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta-protein reduces acetylcholine synthesis in a cell line derived from cholinergic neurons of the basal forebrain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacotherapeutic approaches to the prevention of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic neuropathology in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of nicotine on APP secretion and Abeta- or CT(105)-induced toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Short- and long-term effect of acetylcholinesterase inhibition on the expression and metabolism of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein and membrane phospholipids in primary cortical neurons increase with development, or after exposure to nerve growth factor or Abeta(1-40)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of PPF and ALCAR on the induction of NGF- and p75-mRNA and on APP processing in Tg2576 brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinesterase inhibitors increase secretion of APPs in rat brain cortex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscarinic M1 receptor agonists increase the secretion of the amyloid precursor protein ectodomain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Competitive substrate inhibition in the histochemistry of cholinesterase activity in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Muscarine enhances soluble amyloid precursor protein secretion in human neuroblastoma SH-SY5Y by a pathway dependent on protein kinase C(alpha), src-tyrosine kinase and extracellular signal-regulated kinase but not phospholipase C.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

P75 neurotrophin receptor in the nucleus basalis of meynert in relation to age, sex, and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular interactions of acetylcholinesterase with senile plaques.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholinergic agonists stimulate secretion of soluble full-length amyloid precursor protein in neuroendocrine cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The toxicity of tumor necrosis factor-α upon cholinergic neurons within the nucleus basalis and the role of norepinephrine in the regulation of inflammation: implications for alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nontoxic amyloid beta peptide 1-42 suppresses acetylcholine synthesis. Possible role in cholinergic dysfunction in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid(Phe(SO3H)24)25-35 in rat nucleus basalis induces behavioral dysfunctions, impairs learning and memory and disrupts cortical cholinergic innervation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic acetylcholine receptor immunohistochemistry in Alzheimer's disease and dementia with Lewy bodies: differential neuronal and astroglial pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cholesterol, statins and dementia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable complexes involving acetylcholinesterase and amyloid-beta peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cholinergic lesion of Alzheimer's disease: pivotal factor or side show?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathological and biochemical consequences of acute and chronic neuroinflammation within the basal forebrain cholinergic system of rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta -Amyloid peptide blocks the response of alpha 7-containing nicotinic receptors on hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A monoclonal antibody against acetylcholinesterase inhibits the formation of amyloid fibrils induced by the enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor signaling, neuroprotection, and neural repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase-positive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein london mutant transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurotrophin binding to the p75 neurotrophin receptor is necessary but not sufficient to mediate NGF-effects on APP secretion in PC-12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time course of the development of Alzheimer-like pathology in the doubly transgenic PS1+APP mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The neural mechanisms underlying cholinergic cell death within the basal forebrain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease and the basal forebrain cholinergic system: relations to beta-amyloid peptides, cognition, and treatment strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of presenilin-1 by nerve growth factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine breaks down preformed Alzheimer's beta-amyloid fibrils in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer plaques and cortical cholinergic innervation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The presence of the APP(swe) mutation in mice does not increase the vulnerability of cholinergic basal forebrain neurons to neuroinflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging, amyloid, and Alzheimer's disease: a perspective in honor of Carl Cotman

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibitory and facilitatory actions of amyloid-beta peptides on nicotinic ACh receptors and AMPA receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cortico-hippocampal APP and NGF levels are dynamically altered by cholinergic muscarinic antagonist or M1 agonist treatment in normal mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid neurotoxicity is mediated by a glutamate-triggered excitotoxic cascade in rat nucleus basalis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor modulates the expression and secretion of beta-amyloid precursor protein through different mechanisms in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central cholinergic functions in human amyloid precursor protein knock-in/presenilin-1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppressed expression of nicotinic acetylcholine receptors by nanomolar beta-amyloid peptides in PC12 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta -Amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammatory perspectives on the two faces of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WAL 2014--a muscarinic agonist with preferential neuron-stimulating properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor (NGF) augments cortical and hippocampal cholinergic functioning after p75NGF receptor-mediated deafferentation but impairs inhibitory avoidance and induces fear-related behaviors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotine reduces A beta in the brain and cerebral vessels of APPsw mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease and NGF signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alterations in cholinergic and non‐cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with β‐amyloid plaque pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase BACE1 is differentially controlled through muscarinic acetylcholine receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

NGF content in the cerebral cortex of non-demented patients with amyloid-plaques and in symptomatic Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid binds to p57NTR and activates NFkappaB in human neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Entorhinal cortex beta-amyloid load in individuals with mild cognitive impairment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tyrosine phosphorylation-dependent stimulation of amyloid precursor protein secretion by the m3 muscarinic acetylcholine receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo consequences of M1-receptor activation by talsaclidine

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogen-activated protein kinase-dependent and protein kinase C-dependent pathways link the m1 muscarinic receptor to beta-amyloid precursor protein secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of nicotinic receptors induced by beta-amyloid peptides in PC12 cells: possible mechanism involving lipid peroxidation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging-related down-regulation of neprilysin, a putative beta-amyloid-degrading enzyme, in transgenic Tg2576 Alzheimer-like mouse brain is accompanied by an astroglial upregulation in the vicinity of beta-amyloid plaques.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Colocalization of cholinesterases with beta amyloid protein in aged and Alzheimer's brains.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adult mouse astrocytes degrade amyloid-beta in vitro and in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16187224

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11064-005-6962-9

1 reference

Europe PubMed Central

13 August 2017

1 reference

Europe PubMed Central

13 August 2017

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