Small molecule regulation of Sir2 protein deacetylases (Q36255278)

13 August 2017

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title

Small molecule regulation of Sir2 protein deacetylases (English)

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13 August 2017

Olivera Grubisha

1

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13 August 2017

Brian C Smith

series ordinal

2

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13 August 2017

John M Denu

series ordinal

3

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13 August 2017

language of work or name

English

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publication date

1 September 2005

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13 August 2017

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13 August 2017

272

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13 August 2017

4607-4616

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13 August 2017

18

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The human histone deacetylase family

13 August 2017

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

The Sir2 family of protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Mammalian SIRT1 represses forkhead transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Linking chromatin function with metabolic networks: Sir2 family of NAD(+)-dependent deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Genetic pathways that regulate ageing in model organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Yeast life-span extension by calorie restriction is independent of NAD fluctuation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Calorie restriction extends yeast life span by lowering the level of NADH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

The new life of a centenarian: signalling functions of NAD(P).

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Identification of a small molecule inhibitor of Sir2p

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Nicotinamide: a jack of all trades (but master of none?)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Extrachromosomal rDNA circles--a cause of aging in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Plasmid accumulation reduces life span in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

How does calorie restriction work?

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Caloric restriction and aging: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2005.04862.X

10.1111/J.1742-4658.2005.04862.X

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference