Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma (Q36247293)

13 August 2017

Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma (English)

1 reference

13 August 2017

Ju-Fang Liu

1

1 reference

13 August 2017

Chun-Han Hou

2

1 reference

13 August 2017

Feng-Ling Lin

3

1 reference

13 August 2017

Ya-Ting Tsao

4

1 reference

13 August 2017

Sheng-Mou Hou

5

1 reference

13 August 2017

language of work or name

English

0 references

publication date

29 September 2015

1 reference

International Journal of Molecular Sciences

13 August 2017

1 reference

13 August 2017

16

1 reference

13 August 2017

10

1 reference

13 August 2017

23405-23424

1 reference

Creative Commons Attribution 4.0 International

13 August 2017

start time

29 September 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Cantharidin induces G2/M phase arrest by inhibition of Cdc25c and Cyclin A and triggers apoptosis through reactive oxygen species and the mitochondria‑dependent pathways of A375.S2 human melanoma cells

1 October 2017

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Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

1 October 2017

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Chemopreventive and therapeutic effects of nimbolide in cancer: the underlying mechanisms

1 October 2017

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1 October 2017

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1 October 2017

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Ribosylation of bovine serum albumin induces ROS accumulation and cell death in cancer line (MCF-7).

1 October 2017

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Role of the ROS/AMPK signaling pathway in tetramethylpyrazine-induced apoptosis in gastric cancer cells

1 October 2017

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Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line

1 October 2017

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1 October 2017

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1 October 2017

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Calpain system protein expression in basal-like and triple-negative invasive breast cancer

1 October 2017

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

1 October 2017

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Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells

1 October 2017

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Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

1 October 2017

1 reference

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FPTB, a novel CA-4 derivative, induces cell apoptosis of human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways

1 October 2017

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Role of Bcl-2 family proteins and caspases in the regulation of apoptosis.

1 October 2017

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Nephroblastoma overexpressed gene (NOV) enhances cell motility and COX-2 upregulation of human osteosarcoma involves αvβ5 integrin, ILK and AP-1-dependent pathways

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

The oxidative stress: endoplasmic reticulum stress axis in cadmium toxicity

1 October 2017

1 reference

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BFPP, a phloroglucinol derivative, induces cell apoptosis in human chondrosarcoma cells through endoplasmic reticulum stress

1 October 2017

1 reference

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The role of mitochondria in apoptosis*.

1 October 2017

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DDTD, an isoflavone derivative, induces cell apoptosis through the reactive oxygen species/apoptosis signal-regulating kinase 1 pathway in human osteosarcoma cells

1 October 2017

1 reference

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Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

1 October 2017

1 reference

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Dysregulation of apoptotic signaling in cancer: molecular mechanisms and therapeutic opportunities

1 October 2017

1 reference

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Involvement of matrix metalloproteinase-9 in stromal cell-derived factor-1/CXCR4 pathway of lung cancer metastasis

1 October 2017

1 reference

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Integrin trafficking and its role in cancer metastasis

1 October 2017

1 reference

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Antiproliferative effect on human cancer cell lines after treatment with nimbolide extracted from an edible part of the neem tree (Azadirachta indica).

1 October 2017

1 reference

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DNA damage-induced cell death by apoptosis.

1 October 2017

1 reference

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The role of high-dose therapy and autologous stem cell transplantation for pediatric bone and soft tissue sarcomas.

1 October 2017

1 reference

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Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

1 October 2017

Cell migration in tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Tirapazamine cytotoxicity for neuroblastoma is p53 dependent.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Reactive oxygen species in tumor progression

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Functional dichotomy of A20 in apoptotic and necrotic cell death

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Apoptosis as a novel target for cancer chemoprevention

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Reactive oxygen special (ROS), troublemakers between nuclear factor-kB (NF-kB) and c-Jun NH2-terminal kinase (JNK)

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Cell respiration and formation of reactive oxygen species: facts and artefacts

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Reduced DNA double strand breaks in chlorambucil resistant cells are related to high DNA-PKcs activity and low oxidative stress.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

ROS, stress-activated kinases and stress signaling in cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity

1 October 2017

1 reference

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The glucose-regulated proteins: stress induction and clinical applications

1 October 2017

1 reference

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Mitochondrial permeability transition and oxidative stress

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.

1 October 2017

1 reference

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Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress

1 October 2017

1 reference

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Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells

29 June 2018

1 reference

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Nimbolide, a constituent of Azadirachta indica, inhibits Plasmodium falciparum in culture.

29 June 2018

1 reference

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Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. Updated results of the Multi-Institutional Osteosarcoma Study

29 June 2018

1 reference

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Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Gambogenic acid induced mitochondrial-dependent apoptosis and referred to phospho-Erk1/2 and phospho-p38 MAPK in human hepatoma HepG2 cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Ubiquitous calpains promote caspase-12 and JNK activation during endoplasmic reticulum stress-induced apoptosis.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

Estrogen exerts a spatial and temporal influence on reactive oxygen species generation that precedes calcium uptake in high-capacity mitochondria: implications for rapid nongenomic signaling of cell growth

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4632706

22 September 2018

Road map to metastasis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26426012

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/IJMS161023405

1 reference

release_vlun36xoazhsdhunqdgs7kkp4u

13 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vlun36xoazhsdhunqdgs7kkp4u

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

13 August 2017

1 reference