TAp73 depletion accelerates aging through metabolic dysregulation (Q36240893)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22987635%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

title

TAp73 depletion accelerates aging through metabolic dysregulation (English)

1 reference

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13 February 2020

4

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13 February 2020

Isaac Harris

5

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13 February 2020

Massimo Federici

7

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13 February 2020

author name string

Alessandro Rufini

1

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13 February 2020

Maria Victoria Niklison-Chirou

2

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13 February 2020

Satoshi Inoue

3

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13 February 2020

Arianna Marino

6

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13 February 2020

David Dinsdale

8

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13 February 2020

Richard A Knight

9

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13 February 2020

Gerry Melino

10

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13 February 2020

Tak Wah Mak

11

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13 February 2020

publication date

1 September 2012

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13 February 2020

1 reference

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13 February 2020

volume

26

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13 February 2020

issue

18

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13 February 2020

page(s)

2009-2014

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Axis of ageing: telomeres, p53 and mitochondria

13 February 2020

cites work

1 reference

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Telomere dysfunction induces metabolic and mitochondrial compromise.

1 October 2017

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Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

1 October 2017

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Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration

1 October 2017

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Mitochondrial respiration protects against oxygen-associated DNA damage

1 October 2017

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The origins and evolution of the p53 family of genes

1 October 2017

1 reference

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p53 regulation of metabolic pathways

1 October 2017

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1 October 2017

The genetics of ageing

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Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

1 October 2017

1 reference

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p63 and p73 transcriptionally regulate genes involved in DNA repair

1 October 2017

1 reference

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Reactive oxygen species enhance insulin sensitivity

1 October 2017

1 reference

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When a theory of aging ages badly.

1 October 2017

1 reference

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TAp63 prevents premature aging by promoting adult stem cell maintenance

1 October 2017

1 reference

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Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice

1 October 2017

1 reference

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Bmi1 regulates mitochondrial function and the DNA damage response pathway

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444727

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

1 October 2017

1 reference

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The Arf/p53 pathway in cancer and aging

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444727

p53 regulates mitochondrial respiration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444727

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444727

p63 deficiency activates a program of cellular senescence and leads to accelerated aging

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3444727

Mitochondria, oxidants, and aging

1 October 2017

1 reference

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Ink4a/Arf expression is a biomarker of aging

1 October 2017

1 reference

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

1 October 2017

1 reference

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

1 October 2017

1 reference

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p73: Friend or foe in tumorigenesis

1 October 2017

1 reference

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

1 October 2017

1 reference

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The p53 family: guardians of maternal reproduction.

1 October 2017

1 reference

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Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice

22 September 2018

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A crucial role for adipose tissue p53 in the regulation of insulin resistance

22 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22987635

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Liver mitochondrial respiratory functions decline with age

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22987635

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Oxidative Stress Contributes to Aging by Enhancing Pancreatic Angiogenesis and Insulin Signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22987635

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.197640.112

1 reference

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13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22987635%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22987635%20AND%20SRC:MED&resulttype=core&format=json