Mitochondrial dysfunction and antiretroviral nucleoside analog toxicities: what is the evidence? (Q36239813)

13 August 2017

title

Mitochondrial dysfunction and antiretroviral nucleoside analog toxicities: what is the evidence? (English)

1 reference

13 August 2017

main subject

anti-retroviral agent

0 references

author name string

Tamir Dagan

1

1 reference

13 August 2017

Craig Sable

2

1 reference

13 August 2017

June Bray

3

1 reference

13 August 2017

Mariana Gerschenson

4

1 reference

13 August 2017

publication date

1 May 2002

1 reference

13 August 2017

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13 August 2017

volume

1

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13 August 2017

issue

5

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13 August 2017

page(s)

397-412

1 reference

Emerging patterns of heart disease in HIV infected homosexual subjects with and without opportunistic infections; a prospective colour flow Doppler echocardiographic study

13 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Acute pancreatitis with severe lactic acidosis in an HIV-infected patient on didanosine therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Schwann cell mitochondrial alterations in peripheral nerves of rabbits treated with 2',3'-dideoxycytidine

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Temporal trends in the incidence of HIV-1-related neurologic diseases: Multicenter AIDS Cohort Study, 1985-1992.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Incidence of dilated cardiomyopathy and detection of HIV in myocardial cells of HIV-positive patients. Gruppo Italiano per lo Studio Cardiologico dei Pazienti Affetti da AIDS.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

3′-Azido-3′-deoxythymidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

2',3'-dideoxycytidine (ddC) toxic neuropathy: a study of 52 patients

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Severe polymyositis-like syndrome associated with zidovudine therapy of AIDS and ARC.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Oxidative DNA damage in fetal tissues after transplacental exposure to 3'-azido-3'-deoxythymidine (AZT)

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Hepatic steatosis and lactic acidosis caused by stavudine in an HIV-infected patient

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Favorable interaction of beta-L(-) nucleoside analogues with clinically approved anti-HIV nucleoside analogues for the treatment of human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Editorial response: hyperlactatemia and hepatic steatosis as features of mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Management of hyperlactatemia: no need for routine lactate measurements

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Adverse effects of antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Excess peripheral neuropathy in patients treated with hydroxyurea plus didanosine and stavudine for HIV infection

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Determination of the blood lactate:pyruvate ratio as a noninvasive test for the diagnosis of zidovudine myopathy.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Zidovudine-induced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Survival of a human immunodeficiency patient with nucleoside-induced lactic acidosis--role of haemodialysis treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Predominantly sensory neuropathy in patients with AIDS and AIDS-related complex

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Lack of long-term effects of in utero exposure to zidovudine among uninfected children born to HIV-infected women. Pediatric AIDS Clinical Trials Group Protocol 219/076 Teams.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Early features of zidovudine-associated myopathy: histopathological findings and clinical correlations

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Heart muscle disease related to HIV infection: prognostic implications

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Peripheral neuropathy and antiretroviral drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Mitochondrial myopathy caused by long-term zidovudine therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Peripheral neuropathy in the acquired immunodeficiency syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Effect of zidovudine and didanosine treatment on heart function in children infected with human immunodeficiency virus

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Acetyl-carnitine deficiency in AIDS patients with neurotoxicity on treatment with antiretroviral nucleoside analogues

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Anti-retroviral therapy, insulin resistance and lipodystrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Symptomatic hyperlactataemia: an emerging complication of antiretroviral therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Fetal patas monkeys sustain mitochondrial toxicity as a result of in utero zidovudine exposure

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Zidovudine-associated myopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Zidovudine-associated myopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Cardiomyopathy Associated with Antiretroviral Therapy in Patients with HIV Infection: A Report of Six Cases

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

The pc12 cell as a model for studies of the mechanism of induction of peripheral neuropathy by anti-HIV-1 dideoxynucleoside analogs

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Effect of 2',3'-dideoxycytidine on oxidative phosphorylation in the PC12 cell, a neuronal model

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Relation of peripheral neuropathy to HIV treatment in four randomized clinical trials including didanosine

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Cardiomyopathy in AIDS: a pathophysiological perspective

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Mitochondrial toxicity of antiviral drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Differential incorporation and removal of antiviral deoxynucleotides by human DNA polymerase gamma

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Dilated cardiomyopathy in HIV-infected patients

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Cardiac structure and function in children with human immunodeficiency virus infection treated with zidovudine

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Absence of Cardiac Toxicity of Zidovudine in Infants

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

"Buffalo hump" in men with HIV-1 infection.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Lipodystrophy in patients naive to HIV protease inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Skeletal muscle mitochondria from AZT-treated rats have a diminished response to chronic electrical stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Rhabdomyolysis in antiretroviral therapy with Lamivudin

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Circulating p24 antigen levels and responses to dideoxycytidine in human immunodeficiency virus (HIV) infections. A phase I and II study

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Lactic acidosis and hepatic steatosis associated with use of stavudine: report of four cases

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Lactic acidosis associated with stavudine administration: a report of five cases

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Incidence of neuropathy in HIV-infected patients on monotherapy versus those on combination therapy with didanosine, stavudine and hydroxyurea

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Incidence of pancreatitis in HIV-infected patients receiving nucleoside reverse transcriptase inhibitor drugs

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Lipodystrophy and long-term therapy with nucleoside reverse transcriptase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Mitochondrial respiratory chain disorders and the liver

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Massive hepatic steatosis and lactic acidosis in a patient with AIDS who was receiving zidovudine

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Transplacental effects of 3'-azido-2',3'-dideoxythymidine (AZT): tumorigenicity in mice and genotoxicity in mice and monkeys.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Temporal development of 2',3'-dideoxyinosine (ddI)-induced peripheral myelinopathy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Increased incidence of peripheral neuropathy with co-administration of stavudine and isoniazid in HIV-infected individuals

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

A syndrome of peripheral fat wasting (lipodystrophy) in patients receiving long-term nucleoside analogue therapy.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Antiretroviral therapy 2000.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Rates and risk factors for adverse events associated with didanosine in the expanded access program

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Evaluation of brain and nerve pathology in rats chronically dosed with ddI or isoniazid

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Lactic acidosis in the setting of antiretroviral therapy for the acquired immunodeficiency syndrome. A case report and review of the literature

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Mitochondrial DNA decrease in subcutaneous adipose tissue of HIV-infected individuals with peripheral lipoatrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Myopathies associated with human immunodeficiency virus and zidovudine: can their effects be distinguished?

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Cardiac complications in children with human immunodeficiency virus infection. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group, National Heart, Lung, and Blood Institute

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

3'-Azidothymidine significantly alters glycosphingolipid synthesis in melanoma cells and decreases the shedding of gangliosides

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Acute HIV infection among patients tested for mononucleosis

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Myopathy with human immunodeficiency virus type 1 (HIV-1) infection: HIV-1 or zidovudine?

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Effect of anti-HIV 2'-beta-fluoro-2',3'-dideoxynucleoside analogs on the cellular content of mitochondrial DNA and on lactate production.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Increased risk of lipodystrophy when nucleoside analogue reverse transcriptase inhibitors are included with protease inhibitors in the treatment of HIV-1 infection

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Lipodystrophy in HIV-1-positive patients is associated with insulin resistance in multiple metabolic pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Fulminant neuropathy and lactic acidosis associated with nucleoside analog therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Mitochondrial diseases in man and mouse

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

31P magnetic resonance spectroscopy suggests impaired mitochondrial function in AZT-treated HIV-infected patients

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Frequency of left ventricular dysfunction and other echocardiographic abnormalities in human immunodeficiency virus seronegative intravenous drug users

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

HIV-associated peripheral neuropathy: epidemiology, pathophysiology and treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

3'-Azidothymidine (zidovudine) inhibits glycosylation and dramatically alters glycosphingolipid synthesis in whole cells at clinically relevant concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Cytochrome c oxidase deficiency in the muscle of patients with zidovudine myopathy is segmental and affects both mitochondrial DNA- and nuclear DNA-encoded subunits

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Zalcitabine. Clinical pharmacokinetics and efficacy.

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Riboflavine and severe lactic acidosis

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Abnormalities of peripheral nerve in patients with human immunodeficiency virus infection

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

Toxicity and efficacy of 2',3'-dideoxycytidine in clinical trials of pigtailed macaques infected with simian retrovirus type 2

1 reference

https://api.crossref.org/works/10.1016%2FS1567-7249%2802%2900003-X

7 January 2021

10.1016/S1567-7249(02)00003-X

Identifiers

DOI

1 reference

13 August 2017

1 reference