Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma (Q36218273)

12 August 2017

Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma (English)

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12 August 2017

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M F Riley

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12 August 2017

M J You

series ordinal

2

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12 August 2017

A S Multani

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3

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12 August 2017

G Lozano

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4

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12 August 2017

language of work or name

English

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publication date

27 April 2015

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12 August 2017

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12 August 2017

35

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12 August 2017

3

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12 August 2017

358-365

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describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4624041/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/onc.2015.88

0 references

cites work

TAp73 enhances the pentose phosphate pathway and supports cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

The Many Faces of MDM2 Binding Partners

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Aging mice have increased chromosome instability that is exacerbated by elevated Mdm2 expression

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Mdm2 promotes genetic instability and transformation independent of p53.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

A novel role for p73 in the regulation of Akt-Foxo1a-Bim signaling and apoptosis induced by the plant lectin, Concanavalin A.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

The role of p73 in hematological malignancies

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

p73 Induces apoptosis via PUMA transactivation and Bax mitochondrial translocation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

p53 family update: p73 and p63 develop their own identities

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Negative regulation of bcl-2 expression by p53 in hematopoietic cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

The p53/p63/p73 family of transcription factors: overlapping and distinct functions.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Mdm2 binds p73 alpha without targeting degradation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia and Burkitt's lymphoma is associated with 5' CpG island methylation.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

MDM2 suppresses p73 function without promoting p73 degradation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Overexpression of Mdm2 in mice reveals a p53-independent role for Mdm2 in tumorigenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Overexpression of the MDM2 oncogene in leukemia and lymphoma

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

MDM2, MDMX and p53 in oncogenesis and cancer therapy

22 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.88

Oncoprotein MDM2 overexpression is associated with poor prognosis in distinct non-Hodgkin's lymphoma entities

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4624041

Elevated Mdm2 expression induces chromosomal instability and confers a survival and growth advantage to B cells

21 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.88

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.88

Frequent inactivation of thep73gene by abnormal methylation or LOH in non-Hodgkin's lymphomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.88

p73 suppresses polyploidy and aneuploidy in the absence of functional p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.88

Effects of dehydroepiandrosterone and calorie restriction on the Bcl-2/Bax-mediated apoptotic pathway in p53-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2015.88

Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25915849

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/ONC.2015.88

1 reference

release_uk4rxnude5gkrkpohyfpxoexau

12 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/uk4rxnude5gkrkpohyfpxoexau

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

12 August 2017

1 reference