Targeting of cytotoxic luteinizing hormone-releasing hormone analogs to breast, ovarian, endometrial, and prostate cancers (Q36202016)

12 August 2017

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title

Targeting of cytotoxic luteinizing hormone-releasing hormone analogs to breast, ovarian, endometrial, and prostate cancers (English)

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12 August 2017

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2

Andrew V Schally

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12 August 2017

Attila Nagy

1

1 reference

PubMed ID

16033997

12 August 2017

language of work or name

English

1 reference

inferred from

Biology of Reproduction

publication date

20 July 2005

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12 August 2017

Biology of Reproduction

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12 August 2017

73

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12 August 2017

5

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12 August 2017

851-859

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Chemotherapy targeted to cancers through tumoral hormone receptors

12 August 2017

1 reference

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Peptide receptors as molecular targets for cancer diagnosis and therapy

21 January 2018

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Cancer chemotherapy based on targeting of cytotoxic peptide conjugates to their receptors on tumors.

21 January 2018

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New approaches to treatment of various cancers based on cytotoxic analogs of LHRH, somatostatin and bombesin

21 January 2018

1 reference

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Targeting cytotoxic conjugates of somatostatin, luteinizing hormone-releasing hormone and bombesin to cancers expressing their receptors: a "smarter" chemotherapy

21 January 2018

1 reference

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Cytotoxic analogs of luteinizing hormone-releasing hormone containing doxorubicin or 2-pyrrolinodoxorubicin, a derivative 500-1000 times more potent

21 January 2018

1 reference

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Gonadotropin-releasing hormone: one polypeptide regulates secretion of luteinizing and follicle-stimulating hormones.

21 January 2018

1 reference

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Hypothalamic hormones and cancer

21 January 2018

1 reference

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Inhibition of growth of human mammary tumor cells by potent antagonists of luteinizing hormone-releasing hormone

21 January 2018

1 reference

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Expression of receptors for luteinizing hormone-releasing hormone in human ovarian and endometrial cancers: frequency, autoregulation, and correlation with direct antiproliferative activity of luteinizing hormone-releasing hormone analogues

21 January 2018

1 reference

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Specific low affinity binding sites for gonadotropin-releasing hormone in human endometrial carcinomata

21 January 2018

1 reference

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The effects of gonadotrophin releasing hormone analogues in prostate cancer are mediated through specific tumour receptors

21 January 2018

1 reference

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Gonadotropin-releasing hormone receptor expression in the human prostate

21 January 2018

1 reference

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A conjugate of doxorubicin and an analog of Luteinizing Hormone-Releasing Hormone shows increased efficacy against oral and laryngeal cancers

21 January 2018

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Effects of luteinising-hormone-releasing hormone on nervous-system tumours.

21 January 2018

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Locally expressed LHRH receptors mediate the oncostatic and antimetastatic activity of LHRH agonists on melanoma cells.

21 January 2018

1 reference

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Targeted cancer therapy with gonadotropin-releasing hormone chimeric proteins

21 January 2018

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The molecular basis of gonadotropin-releasing hormone action

21 January 2018

1 reference

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Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus

21 January 2018

1 reference

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Regulation of gonadotropin-releasing hormone receptors by protein kinase C: inside out signalling and evidence for multiple active conformations

21 January 2018

1 reference

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Signalling and anti-proliferative effects mediated by gonadotrophin-releasing hormone receptors after expression in prostate cancer cells using recombinant adenovirus

21 January 2018

1 reference

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Signaling and antiproliferative effects of type I and II gonadotropin-releasing hormone receptors in breast cancer cells

21 January 2018

1 reference

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Effects of LHRH-analogues on mitogenic signal transduction in cancer cells.

21 January 2018

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Regulation of luteinizing hormone-releasing hormone receptor binding by heterologous and autologous receptor-stimulated tyrosine phosphorylation

21 January 2018

1 reference

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LHRH might act as a negative autocrine regulator of proliferation of human ovarian cancer

21 January 2018

1 reference

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The nucleotide sequences of human GnRH receptors in breast and ovarian tumors are identical with that found in pituitary

21 January 2018

1 reference

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Binding and cytotoxicity of conjugated and recombinant fusion proteins targeted to the gonadotropin-releasing hormone receptor.

21 January 2018

1 reference

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Anti-gonadotrophin releasing hormone antibodies inhibit the growth of MCF7 human breast cancer xenografts

21 January 2018

1 reference

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Linker-based GnRH-PE chimeric proteins inhibit cancer growth in nude mice

21 January 2018

1 reference

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I.V. Administration of L-GNRH-PE66 efficiently inhibits growth of colon adenocarcinoma xenografts in nude mice

21 January 2018

1 reference

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Cytotoxic activity of a recombinant GnRH-PAP fusion toxin on human tumor cell lines.

21 January 2018

1 reference

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Analogues of luteinizing hormone-releasing hormone containing cytotoxic groups

21 January 2018

1 reference

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High yield conversion of doxorubicin to 2-pyrrolinodoxorubicin, an analog 500-1000 times more potent: structure-activity relationship of daunosamine-modified derivatives of doxorubicin

21 January 2018

1 reference

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A chemically labeled cytotoxic agent: two-photon fluorophore for optical tracking of cellular pathway in chemotherapy

21 January 2018

1 reference

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Administration of a targeted cytotoxic analog of luteinizing hormone-releasing hormone inhibits growth of estrogen-independent MDA-MB-231 human breast cancers in nude mice.

21 January 2018

1 reference

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Effective treatment of experimental ES-2 human ovarian cancers with a cytotoxic analog of luteinizing hormone-releasing hormone AN-207.

21 January 2018

1 reference

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In vitro targeting of a cytotoxic analog of luteinizing hormone-releasing hormone AN-207 to ES-2 human ovarian cancer cells as demonstrated by microsatellite analyses.

21 January 2018

1 reference

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Effective treatment of experimental human endometrial cancers with targeted cytotoxic luteinizing hormone-releasing hormone analogues AN-152 and AN-207.

21 January 2018

1 reference

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Internalization of cytotoxic analog AN-152 of luteinizing hormone-releasing hormone induces apoptosis in human endometrial and ovarian cancer cell lines independent of multidrug resistance-1 (MDR-1) system

21 January 2018

1 reference

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Role of programmed (apoptotic) cell death during the progression and therapy for prostate cancer

21 January 2018

1 reference

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Recovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone.

21 January 2018

1 reference

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Stability of cytotoxic luteinizing hormone-releasing hormone conjugate (AN-152) containing doxorubicin 14-O-hemiglutarate in mouse and human serum in vitro: implications for the design of preclinical studies.

21 January 2018

1 reference

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Outside-In and Inside-Out Signaling: The New Concept that Selectivity of Ligand Binding at the Gonadotropin-Releasing Hormone Receptor Is Modulated by the Intracellular Environment

21 January 2018

1 reference

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Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist

21 January 2018

1 reference

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Gonadotropin-releasing hormone specific binding sites in normal and malignant renal tissue

21 January 2018

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11 October 2022

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Doxoform and Daunoform: anthracycline-formaldehyde conjugates toxic to resistant tumor cells

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Targeted cytotoxic analog of luteinizing hormone-releasing hormone AN-207 inhibits the growth of PC-82 human prostate cancer in nude mice

1 reference

11 October 2022

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Targeted cytotoxic analog of luteinizing hormone-releasing hormone AN-207 inhibits growth of OV-1063 human epithelial ovarian cancers in nude mice

1 reference

11 October 2022

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Inhibition of growth of experimental prostate cancer in rats by LH-RH analogs linked to cytotoxic radicals

1 reference

11 October 2022

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High incidence of receptors for luteinizing hormone-releasing hormone (LHRH) and LHRH receptor gene expression in human prostate cancers

1 reference

11 October 2022

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Growth inhibition of human ovarian cancers by cytotoxic analogues of luteinizing hormone-releasing hormone

1 reference

11 October 2022

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Gonadotropin releasing hormone binding sites in human epithelial ovarian carcinomata

1 reference

11 October 2022

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Characteristics and distribution of receptors for [D-TRP6]-luteinizing hormone-releasing hormone, somatostatin, epidermal growth factor, and sex steroids in 500 biopsy samples of human breast cancer

1 reference

11 October 2022

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Complete regression of MX-1 human breast carcinoma xenografts after targeted chemotherapy with a cytotoxic analog of luteinizing hormone-releasing hormone, AN-207

1 reference

11 October 2022

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Human prostate cancer cells and xenografts are targeted and destroyed through luteinizing hormone releasing hormone receptors

1 reference

11 October 2022

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Gonadotropin-releasing hormone binding sites in human breast carcinoma

1 reference

11 October 2022

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Characterization of binding sites for a GnRH-agonist (buserelin) in human breast cancer biopsies and their distribution in relation to tumor parameters

1 reference

11 October 2022

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Binding and activation of gonadotropin-releasing hormone receptors in pituitary and gonadal cells.

1 reference

11 October 2022

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Inhibition of in vivo proliferation of MDA-PCa-2b human prostate cancer by a targeted cytotoxic analog of luteinizing hormone-releasing hormone AN-207

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1095/BIOLREPROD.105.043489

Cytotoxic analogs of luteinizing hormone-releasing hormone bind with high affinity to human breast cancers

1 reference

11 October 2022

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Antitumor effects of the cytotoxic luteinizing hormone-releasing hormone analog AN-152 on human endometrial and ovarian cancers xenografted into nude mice

1 reference

11 October 2022

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Membrane receptors for peptides in experimental and human pancreatic cancers

1 reference

11 October 2022

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Targeted cytotoxic luteinizing hormone releasing hormone (LH-RH) anlalogs inhibit growth of estrogen independent MXT mouse mammary cancers in vivo by decreasing cell proliferation and inducing apoptosis

1 reference

11 October 2022

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Identifiers

DOI

10.1095/BIOLREPROD.105.043489

1 reference

12 August 2017

1 reference

PubMed ID

16033997