The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. (Q36193554)

12 August 2017

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. (English)

1 reference

12 August 2017

Jörg Heierhorst

8

0 references

Carl R Walkley

Carl R Walkley

5

0 references

David M Tarlinton

David M Tarlinton

7

0 references

Andreas Strasser

Andreas Strasser

6

0 references

Sabine Jurado

1

Sabine Jurado

1 reference

12 August 2017

3

Kristy O'Donnell

1 reference

12 August 2017

Kimberly Gleeson

2

1 reference

PMCID

3428950

12 August 2017

David J Izon

4

1 reference

PMCID

3428950

12 August 2017

language of work or name

English

0 references

publication date

13 August 2012

1 reference

Journal of Experimental Medicine

12 August 2017

1 reference

12 August 2017

209

1 reference

12 August 2017

9

1 reference

12 August 2017

1629-1639

1 reference

ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Directed Evolution Reveals the Binding Motif Preference of the LC8/DYNLL Hub Protein and Predicts Large Numbers of Novel Binders in the Human Proteome

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Dampening of death pathways by schnurri-2 is essential for T-cell development

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Apurinic/apyrimidinic endonuclease 2 is necessary for normal B cell development and recovery of lymphoid progenitors after chemotherapeutic challenge.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Dynein-independent functions of DYNLL1/LC8: redox state sensing and transcriptional control

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

B lymphocytes: how they develop and function.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

DNA damage response protein ASCIZ links base excision repair with immunoglobulin gene conversion

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Mechanism and regulation of class switch recombination

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

The biochemistry of somatic hypermutation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Testing gene function early in the B cell lineage in mb1-cre mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

The role of BH3-only proteins in the immune system

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

B lymphocyte-specific, Cre-mediated mutagenesis in mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Production of high-titer helper-free retroviruses by transient transfection

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Inducible gene targeting in mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

RAG-1-deficient mice have no mature B and T lymphocytes

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

Dynein light chain LC8 is a dimerization hub essential in diverse protein networks.

2 July 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120785

Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120785

Noradrenaline represses PPAR (peroxisome-proliferator-activated receptor) gamma2 gene expression in brown adipocytes: intracellular signalling and effects on PPARgamma2 and PPARgamma1 protein levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120785

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120785

The M(r) = 8,000 and 11,000 outer arm dynein light chains from Chlamydomonas flagella have cytoplasmic homologues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120785

B cell receptor-mediated antigen gathering requires ubiquitin ligase Cbl and adaptors Grb2 and Dok-3 to recruit dynein to the signaling microcluster.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120785

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120785

Insulin-like growth factor 2 expressed in a novel fetal liver cell population is a growth factor for hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20120785

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3428950

A breathtaking phenotype: Unexpected roles of the DNA base damage response protein ASCIZ as a key regulator of early lung development

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22891272

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1084/JEM.20120785

1 reference

12 August 2017

1 reference

12 August 2017

1 reference

PMCID

3428950