Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells (Q36186265)

12 August 2017

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells (English)

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12 August 2017

13

Stuart J Frank

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12 August 2017

Hainan Chen

1

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12 August 2017

Jeffrey W Kleinberger

2

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12 August 2017

Karen K Takane

3

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12 August 2017

Fatimah Salim

4

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12 August 2017

Nathalie Fiaschi-Taesch

5

1 reference

12 August 2017

Kyrie Pappas

6

1 reference

12 August 2017

Ramon Parsons

7

1 reference

12 August 2017

Jing Jiang

8

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12 August 2017

Yue Zhang

9

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12 August 2017

Hongtao Liu

10

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12 August 2017

Peng Wang

11

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12 August 2017

Aaron S Bender

12

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12 August 2017

Andrew F Stewart

14

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12 August 2017

language of work or name

English

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publication date

9 July 2015

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12 August 2017

14

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inferred from page(s)

published in

Diabetes

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12 August 2017

64

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12 August 2017

3784-3797

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12 August 2017

11

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describes a project that uses

12 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4613973/fullTextXML

inferred from PubMed Central ID database lookup

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1 October 2017

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Knockdown of prolactin receptors in a pancreatic beta cell line: effects on DNA synthesis, apoptosis, and gene expression

1 October 2017

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CISH has no non-redundant functions in glucose homeostasis or beta cell proliferation during pregnancy in mice

1 October 2017

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Formation of a human β-cell population within pancreatic islets is set early in life

1 October 2017

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Loss of HGF/c-Met signaling in pancreatic β-cells leads to incomplete maternal β-cell adaptation and gestational diabetes mellitus.

1 October 2017

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Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling

1 October 2017

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PDGF signalling controls age-dependent proliferation in pancreatic β-cells

1 October 2017

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cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication.

1 October 2017

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Placental lactogens induce serotonin biosynthesis in a subset of mouse beta cells during pregnancy

1 October 2017

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Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice

1 October 2017

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Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6

1 October 2017

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FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation

1 October 2017

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Serotonin regulates pancreatic beta cell mass during pregnancy

1 October 2017

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Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy

1 October 2017

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Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents

1 October 2017

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1 October 2017

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Gestational diabetes mellitus resulting from impaired beta-cell compensation in the absence of FoxM1, a novel downstream effector of placental lactogen

1 October 2017

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Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states

1 October 2017

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Survey of the human pancreatic beta-cell G1/S proteome reveals a potential therapeutic role for cdk-6 and cyclin D1 in enhancing human beta-cell replication and function in vivo

1 October 2017

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Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function

1 October 2017

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Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus

1 October 2017

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Glucose infusion in mice: a new model to induce beta-cell replication

1 October 2017

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Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1

1 October 2017

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Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice

1 October 2017

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Activated STAT5 proteins induce activation of the PI 3-kinase/Akt and Ras/MAPK pathways via the Gab2 scaffolding adapter

1 October 2017

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Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth

1 October 2017

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 October 2017

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Prolactin receptors and JAK2 in islets of Langerhans: an immunohistochemical analysis

1 October 2017

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Adaptation of islets of Langerhans to pregnancy: beta-cell growth, enhanced insulin secretion and the role of lactogenic hormones

1 October 2017

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Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression.

2 July 2018

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Prolactin treatment improves engraftment and function of transplanted pancreatic islets.

23 September 2018

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Pancreatic beta-cell mass in European subjects with type 2 diabetes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613973

Proliferation of sorted human and rat beta cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613973

Partial pancreatectomy in adult humans does not provoke beta-cell regeneration

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613973

Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613973

Targeted deletion of the PRL receptor: effects on islet development, insulin production, and glucose tolerance

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613973

Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613973

Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells

23 September 2018

1 reference

12 December 2020

Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islet function during pregnancy

1 reference

12 December 2020

Prolactin regulation of islet-derived INS-1 cells: characteristics and immunocytochemical analysis of STAT5 translocation

1 reference

12 December 2020

STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB15-0083

1 reference

12 August 2017

1 reference

12 August 2017

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