Priorities and standards in pharmacogenetic research (Q36180606)

12 August 2017

title

Priorities and standards in pharmacogenetic research (English)

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12 August 2017

1

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12 August 2017

Arno G Motulsky

2

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12 August 2017

David B Goldstein

series ordinal

3

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12 August 2017

publication date

1 July 2005

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12 August 2017

language of work or name

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12 August 2017

volume

37

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12 August 2017

issue

7

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12 August 2017

page(s)

671-681

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publication type of scholarly work

12 August 2017

review article

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Pharmacogenetics goes genomic

cites work

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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Management of treatment resistance in schizophrenia

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Modelling the impact of clozapine on suicide in patients with treatment-resistant schizophrenia in the UK.

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Pharmacogenetic aspects of drug-induced torsade de pointes: potential tool for improving clinical drug development and prescribing

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Drugs that cause Torsades de pointes and increase the risk of sudden cardiac death

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Pharmacogenetics and drug development: the path to safer and more effective drugs

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Cancer statistics, 1997.

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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Beyond Herceptin and Gleevec

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Inheritance and drug response

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Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

21 January 2018

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The role of cost-effectiveness analysis in the era of pharmacogenomics

21 January 2018

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Disease-specific target selection: a critical first step down the right road

21 January 2018

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Pharmacogenomics and "individualized drug therapy": high expectations and disappointing achievements

21 January 2018

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Advances in pharmacogenomics and individualized drug therapy: exciting challenges that lie ahead

21 January 2018

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Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin

21 January 2018

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Clinical-pathological study of levodopa complications

21 January 2018

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Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia

21 January 2018

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Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis

21 January 2018

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Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment

21 January 2018

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Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics

21 January 2018

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Genome-wide discovery of loci influencing chemotherapy cytotoxicity

21 January 2018

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Serum proteomic profiles suggest celecoxib-modulated targets and response predictors

21 January 2018

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Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease

21 January 2018

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Efficiency and consistency of haplotype tagging of dense SNP maps in multiple samples

21 January 2018

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Linkage disequilibrium in the human genome

21 January 2018

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Demography, recombination hotspot intensity, and the block structure of linkage disequilibrium

21 January 2018

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A permutation procedure for the haplotype method for identification of disease-predisposing variants

21 January 2018

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Detecting association in a case-control study while correcting for population stratification

21 January 2018

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Genomic control for association studies

21 January 2018

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Pharmacogenetics in the laboratory and the clinic

21 January 2018

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Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene

21 January 2018

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Phylogenetic shadowing of primate sequences to find functional regions of the human genome

21 January 2018

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eShadow: a tool for comparing closely related sequences

21 January 2018

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Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus

21 January 2018

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Translation of pharmacogenomics and pharmacogenetics: a regulatory perspective

21 January 2018

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Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response

21 January 2018

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Will tomorrow's medicines work for everyone?

21 January 2018

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Pharmacokinetics of SLI381 (ADDERALL XR), an extended-release formulation of Adderall

21 January 2018

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Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome

21 January 2018

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A frameshift variant of CYP2C8 was identified in a patient who suffered from rhabdomyolysis after administration of cerivastatin

21 January 2018

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A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter

21 January 2018

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Medical genetics: a marker for Stevens-Johnson syndrome

21 January 2018

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Evidence for a cardiac ion channel mutation underlying drug-induced QT prolongation and life-threatening arrhythmias

21 January 2018

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Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation

21 January 2018

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The fenfluramine metabolite (+)-norfenfluramine is vasoactive

21 January 2018

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The influence of the sparteine/debrisoquine genetic polymorphism on the disposition of dexfenfluramine

21 January 2018

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Serotonin 5-HT(2B) receptor loss of function mutation in a patient with fenfluramine-associated primary pulmonary hypertension.

21 January 2018

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BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives.

21 January 2018

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Involvement of Human UGT2B7 and 2B15 in Rofecoxib Metabolism

21 January 2018

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CYP2D6 and CYP2C19 genotypes of patients with terodiline cardiotoxicity identified through the yellow card system

21 January 2018

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Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity

21 January 2018

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Association of troglitazone-induced liver injury with mutation of the cytochrome P450 2C19 gene

21 January 2018

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A study to survey susceptible genetic factors responsible for troglitazone‐associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus

21 January 2018

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Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin.

21 January 2018

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Cardiovascular hazard and non-steroidal anti-inflammatory drugs

21 January 2018

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A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke

21 January 2018

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Mechanistic basis of adverse drug reactions: the perils of inappropriate dose schedules

21 January 2018

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Reply to 'Haplotype block structure of the cytochrome P450 CYP2C gene cluster on chromosome 10'

21 January 2018

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Genome scans and candidate gene approaches in the study of common diseases and variable drug responses

21 January 2018

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Association studies for quantitative traits in structured populations

21 January 2018

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Haplotype tagging for the identification of common disease genes

21 January 2018

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Waiting for the second coming

21 January 2018

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7 January 2021

Haplotype block structures show significant variation among populations

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7 January 2021

A single-nucleotide polymorphism tagging set for human drug metabolism and transport

1 reference

7 January 2021

Prospects for whole-genome linkage disequilibrium mapping of common disease genes

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7 January 2021

Fenfluramine-induced pulmonary vasoconstriction: role of serotonin receptors and potassium channels

1 reference

7 January 2021

KVLQT1 C-Terminal Missense Mutation Causes a Forme Fruste Long-QT Syndrome

1 reference

7 January 2021

Identifiers

DOI

10.1038/NG1593

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12 August 2017

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