Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levels (Q36174768)

12 August 2017

Cardiotonic steroids stabilize regulator of G protein signaling 2 protein levels (English)

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12 August 2017

6

Richard R Neubig

1 reference

12 August 2017

Benita Sjögren

1

1 reference

12 August 2017

Sergio Parra

2

1 reference

12 August 2017

Lauren J Heath

3

1 reference

12 August 2017

Kevin B Atkins

4

1 reference

12 August 2017

Zie-Jian Xie

5

1 reference

12 August 2017

13 June 2012

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12 August 2017

Molecular Pharmacology

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12 August 2017

82

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12 August 2017

3

1 reference

12 August 2017

500-509

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describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3422705/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Knockout of the Na,K-ATPase α₂-isoform in the cardiovascular system does not alter basal blood pressure but prevents ACTH-induced hypertension

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Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins.

1 October 2017

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Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses

1 October 2017

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A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins

1 October 2017

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Renal actions of RGS2 control blood pressure

1 October 2017

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Regulators of G protein signaling proteins as targets for drug discovery.

1 October 2017

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Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.

1 October 2017

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Low-Dose Digoxin and Reduction in Mortality and Morbidity in Heart Failure

1 October 2017

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Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins

1 October 2017

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Alterations of Na+/K+-ATPase function in caveolin-1 knockout cardiac fibroblasts

1 October 2017

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RGS2 inhibits beta-adrenergic receptor-induced cardiomyocyte hypertrophy

1 October 2017

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Regulation of GPCR signaling in hypertension

1 October 2017

1 reference

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Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse

1 October 2017

1 reference

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Translational control by RGS2.

1 October 2017

1 reference

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Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets

1 October 2017

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A rapid, PPAR-gamma-dependent effect of pioglitazone on the phosphorylation of MYPT.

1 October 2017

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Enhanced pressor response to increased CSF sodium concentration and to central ANG I in heterozygous alpha2 Na+ -K+ -ATPase knockout mice

1 October 2017

1 reference

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Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Ouabain, a circulating hormone secreted by the adrenals, is pivotal in cardiovascular disease. Fact or fantasy?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Small molecule protein-protein interaction inhibitors as CNS therapeutic agents: current progress and future hurdles.

1 October 2017

1 reference

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Regulation of G protein-coupled receptor signalling: focus on the cardiovascular system and regulator of G protein signalling proteins

1 October 2017

1 reference

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Motor coordination deficits in mice lacking RGS9

1 October 2017

1 reference

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Alternative translation initiation of human regulators of G-protein signaling-2 yields a set of functionally distinct proteins

1 October 2017

1 reference

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Cardiac GPCRs: GPCR signaling in healthy and failing hearts

1 October 2017

1 reference

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N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Functional characterization of Src-interacting Na/K-ATPase using RNA interference assay

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

RGS4 and RGS5 are in vivo substrates of the N-end rule pathway

1 October 2017

1 reference

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Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population

1 October 2017

1 reference

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Multi-tasking RGS proteins in the heart: the next therapeutic target?

1 October 2017

1 reference

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Is RGS-2 a new drug development target in cardiovascular disease?

1 October 2017

1 reference

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Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function

1 October 2017

1 reference

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Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5.

1 October 2017

1 reference

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Differentially Regulated Expression of Endogenous RGS4 and RGS7

1 October 2017

1 reference

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The influence of some cations on an adenosine triphosphatase from peripheral nerves

1 October 2017

1 reference

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Identification of RGS2 and type V adenylyl cyclase interaction sites

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Regulator of G protein signaling proteins: novel multifunctional drug targets

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

RGS2/G0S8 is a selective inhibitor of Gqalpha function

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Comparative pharmacology of cardiac glycosides

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Small Molecule Inhibitors of Regulator of G Protein Signalling (RGS) Proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Association and linkage analyses of RGS4 polymorphisms in schizophrenia

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Fine tuning of blood pressure by the regulator of G protein signaling (RGS) 2.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

RGS2 expression and aldosterone: renin ratio modulate response to drug therapy in hypertensive patients.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

RGS2 is upregulated by and attenuates the hypertrophic effect of alpha1-adrenergic activation in cultured ventricular myocytes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Increased expression of regulator of G protein signaling-2 (RGS-2) in Bartter's/Gitelman's syndrome. A role in the control of vascular tone and implication for hypertension.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Inhibitory effects of digitalis on the proliferation of androgen dependent and independent prostate cancer cells

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Distinct molecular phenotypes in murine cardiac muscle development, growth, and hypertrophy.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3422705

Profile of RGS expression in single rat atrial myocytes

23 September 2018

1 reference

12 December 2020

Nanomolar ouabain augments caffeine-evoked contractions in rat arteries

1 reference

12 December 2020

Regulator of G-protein signaling 2 (RGS2) inhibits androgen-independent activation of androgen receptor in prostate cancer cells

1 reference

12 December 2020

Reconsidering the role for digoxin in the management of acute heart failure syndromes

1 reference

12 December 2020

Less RAAS is more, or not

1 reference

12 December 2020

Identifiers

DOI

10.1124/MOL.112.079293

1 reference

release_6xodgg46prcxtlhzkurr4vpcx4

12 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/6xodgg46prcxtlhzkurr4vpcx4

24 November 2022

mapped directly with Wikidata item

1 reference

12 August 2017

1 reference