Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis (Q36165620)

12 August 2017

Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis (English)

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12 August 2017

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Nadine Nagy

1

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12 August 2017

Gernot Kaber

2

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12 August 2017

Pamela Y Johnson

3

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12 August 2017

John A Gebe

4

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12 August 2017

Anton Preisinger

5

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12 August 2017

Ben A Falk

6

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12 August 2017

Vivekananda G Sunkari

7

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12 August 2017

Michel D Gooden

8

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12 August 2017

Robert B Vernon

9

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12 August 2017

Marika Bogdani

10

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12 August 2017

Hedwich F Kuipers

11

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12 August 2017

Anthony J Day

12

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12 August 2017

Daniel J Campbell

13

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12 August 2017

Thomas N Wight

14

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12 August 2017

Paul L Bollyky

15

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12 August 2017

language of work or name

English

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publication date

14 September 2015

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12 August 2017

13

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Journal of Clinical Investigation

inferred from page(s)

published in

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12 August 2017

125

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12 August 2017

3928-3940

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12 August 2017

10

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describes a project that uses

12 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4607113/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS.

1 reference

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Hyaluronan and hyaluronan-binding proteins accumulate in both human type 1 diabetic islets and lymphoid tissues and associate with inflammatory cells in insulitis.

2 October 2017

1 reference

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Targeting hyaluronic acid production for the treatment of leukemia: treatment with 4-methylumbelliferone leads to induction of MAPK-mediated apoptosis in K562 leukemia

2 October 2017

1 reference

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Unexpected new roles for heparanase in Type 1 diabetes and immune gene regulation

2 October 2017

1 reference

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TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity

2 October 2017

1 reference

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Overall sulfation of heparan sulfate from pancreatic islet β-TC3 cells increases maximal fibril formation but does not determine binding to the amyloidogenic peptide islet amyloid polypeptide

2 October 2017

1 reference

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Hyaluronan and hyaluronan binding proteins are normal components of mouse pancreatic islets and are differentially expressed by islet endocrine cell types

2 October 2017

1 reference

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The role of hyaluronan and the extracellular matrix in islet inflammation and immune regulation

2 October 2017

1 reference

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Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes

2 October 2017

1 reference

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Inhibition of hyaluronan retention by 4-methylumbelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo

2 October 2017

1 reference

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The inflammation-associated protein TSG-6 cross-links hyaluronan via hyaluronan-induced TSG-6 oligomers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-κB signaling in resident macrophages.

2 October 2017

1 reference

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ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors.

2 October 2017

1 reference

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Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo

2 October 2017

1 reference

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Hyaluronan deposition and correlation with inflammation in a murine ovalbumin model of asthma

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Hyaluronan as an immune regulator in human diseases.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Cellular requirements for diabetes induction in DO11.10xRIPmOVA mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

2 October 2017

1 reference

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Genetics, pathogenesis and clinical interventions in type 1 diabetes

2 October 2017

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Prediction and pathogenesis in type 1 diabetes.

2 October 2017

1 reference

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Inducible regulatory T cells (iTregs) from recent-onset type 1 diabetes subjects show increased in vitro suppression and higher ITCH levels compared with controls

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Polyinosine-polycytidylic acid stimulates versican accumulation in the extracellular matrix promoting monocyte adhesion.

2 October 2017

1 reference

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Intact extracellular matrix and the maintenance of immune tolerance: high molecular weight hyaluronan promotes persistence of induced CD4+CD25+ regulatory T cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

The role of inflammation in insulitis and beta-cell loss in type 1 diabetes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Expansion of human regulatory T-cells from patients with type 1 diabetes

2 October 2017

1 reference

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Molecular composition of the peri-islet basement membrane in NOD mice: a barrier against destructive insulitis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Toll-like receptor 2 controls expansion and function of regulatory T cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Hyaluronan-binding proteins: tying up the giant

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

The NOD mouse model of type 1 diabetes: as good as it gets?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Treatment with the hyaluronic Acid synthesis inhibitor 4-methylumbelliferone suppresses LPS-induced lung inflammation.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Inhibition of hyaluronan synthesis accelerates murine atherosclerosis: novel insights into the role of hyaluronan synthesis

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

CD44 costimulation promotes FoxP3+ regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Effect of cycloheximide and dexamethasone phosphate on hyaluronic acid synthesis and secretion in cultured human skin fibroblasts

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Inhibition of hyaluronan is protective against renal ischaemia-reperfusion injury

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Role of CD44 in activation-induced cell death: CD44-deficient mice exhibit enhanced T cell response to conventional and superantigens

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Hymecromone in the treatment of motor disorders of the bile ducts: a multicenter, double-blind, placebo-controlled clinical study.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4607113

Suppression of hyaluronan synthesis alleviates inflammatory responses in murine arthritis and in human rheumatoid synovial fibroblasts

23 September 2018

1 reference

12 December 2020

Serum hyaluronan--a non-invasive test for diagnosing liver cirrhosis

1 reference

12 December 2020

Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study

1 reference

12 December 2020

Pharmacokinetics and bioavailabilities of hymecromone in human volunteers

1 reference

12 December 2020

A dot-blot assay of metabolically radiolabeled hyaluronan

1 reference

12 December 2020

Heparanase prevents the development of type 1 diabetes in non-obese diabetic mice by regulating T-cell activation and cytokines production

1 reference

12 December 2020

Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI79271

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12 August 2017

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12 August 2017

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