Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment (Q36149287)

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English	Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment	scientific article

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scholarly article

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Europe PubMed Central

12 August 2017

Regulation of HIF-1α signaling and chemoresistance in acute lymphocytic leukemia under hypoxic conditions of the bone marrow microenvironment (English)

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Europe PubMed Central

12 August 2017

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acute lymphocytic leukemia

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based on heuristic

inferred from title

Hagop Kantarjian

16

object named as

Hagop Kantarjian

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Europe PubMed Central

12 August 2017

12

object named as

Sherry Pierce

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Europe PubMed Central

12 August 2017

Marina Konopleva

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object named as

Marina Konopleva

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Europe PubMed Central

12 August 2017

Michael Andreeff

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object named as

Michael Andreeff

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12 August 2017

Elizabeth J Shpall

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object named as

Elizabeth Shpall

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Rodrigo O Jacamo

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object named as

Rodrigo Jacamo

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Teresa S McQueen

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object named as

Teresa McQueen

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Wendy D Schober

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object named as

Wendy Schober

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Steven M Kornblau

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object named as

Steven M Kornblau

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17

object named as

Richard Lock

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2

object named as

Ismael Samudio

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Europe PubMed Central

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Sergej Konoplev

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object named as

Sergej Konoplev

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Europe PubMed Central

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Juliana Maria Benito

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object named as

Juliana Maria Benito

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author name string

Olga Frolova

1

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12 August 2017

Ana Markovic

6

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12 August 2017

Hongbo Lu

8

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12 August 2017

Yi Hua Qiu

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Daniela Buglio

10

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12 August 2017

Deborah Thomas

15

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12 August 2017

language of work or name

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publication date

1 August 2012

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Cancer Biology and Therapy

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13

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858-870

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10

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12 August 2017

Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Pronounced hypoxia in models of murine and human leukemia: high efficacy of hypoxia-activated prodrug PR-104

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Targeting HIF1α eliminates cancer stem cells in hematological malignancies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Regulation of the HIF-1alpha level is essential for hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Anthracycline chemotherapy inhibits HIF-1 transcriptional activity and tumor-induced mobilization of circulating angiogenic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL).

1 reference

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2 October 2017

A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth

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2 October 2017

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure

1 reference

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2 October 2017

Functional proteomic profiling of AML predicts response and survival

1 reference

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2 October 2017

Evaluation of HIF-1 inhibitors as anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Hypoxia-inducible factor 1alpha is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase

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2 October 2017

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Hypoxia signalling in cancer and approaches to enforce tumour regression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-alpha/Sima

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes

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2 October 2017

PML-RARalpha is associated with leptin-receptor induction: the role of mesenchymal stem cell-derived adipocytes in APL cell survival

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2 October 2017

Mitochondrial respiratory control is lost during growth factor deprivation

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2 October 2017

Growth factors can influence cell growth and survival through effects on glucose metabolism

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2 October 2017

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

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2 October 2017

Stroma-supported culture in childhood B-lineage acute lymphoblastic leukemia cells predicts treatment outcome

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2 October 2017

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3414410

2 October 2017

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction

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2 October 2017

Bone marrow-derived stromal cells prevent apoptotic cell death in B-lineage acute lymphoblastic leukemia

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2 July 2018

Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

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https://api.crossref.org/works/10.4161%2FCBT.20838

21 January 2018

Activation of the HIF pathway in childhood ALL, prognostic implications of VEGF.

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21 January 2018

Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia

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21 January 2018

Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells

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https://api.crossref.org/works/10.4161%2FCBT.20838

21 January 2018

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways

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https://api.crossref.org/works/10.4161%2FCBT.20838

21 January 2018

Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells.

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https://api.crossref.org/works/10.4161%2FCBT.20838

21 January 2018

Hypoxia mediates low cell-cycle activity and increases the proportion of long-term-reconstituting hematopoietic stem cells during in vitro culture.

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https://api.crossref.org/works/10.4161%2FCBT.20838

21 January 2018

High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response.

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https://api.crossref.org/works/10.4161%2FCBT.20838

21 January 2018

Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells.

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https://api.crossref.org/works/10.4161%2FCBT.20838

21 January 2018

Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditions

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https://api.crossref.org/works/10.4161%2FCBT.20838

21 January 2018

Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia

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https://pubmed.ncbi.nlm.nih.gov/22785211

12 December 2020

based on heuristic

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Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway

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https://pubmed.ncbi.nlm.nih.gov/22785211

12 December 2020

based on heuristic

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The nonobese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biologic characteristics at diagnosis and relapse

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https://pubmed.ncbi.nlm.nih.gov/22785211

12 December 2020

based on heuristic

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Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22785211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changing bone marrow micro-environment during development of acute myeloid leukaemia in rats

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https://pubmed.ncbi.nlm.nih.gov/22785211

12 December 2020

based on heuristic

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Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22785211

12 December 2020

based on heuristic

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Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22785211

12 December 2020

based on heuristic

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Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22785211

12 December 2020

based on heuristic

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Identifiers

10.4161/CBT.20838

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Europe PubMed Central

12 August 2017

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Europe PubMed Central

12 August 2017

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Europe PubMed Central

12 August 2017

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