Polycystins: polymodal receptor/ion-channel cellular sensors (Q36124622)

12 August 2017

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title

Polycystins: polymodal receptor/ion-channel cellular sensors (English)

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12 August 2017

Patrick Delmas

1

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12 August 2017

12 May 2005

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12 August 2017

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12 August 2017

451

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12 August 2017

264-276

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12 August 2017

1

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https://scigraph.springernature.com/pub.10.1007/s00424-005-1431-5

12 August 2017

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cites work

The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00424-005-1431-5

Transepithelial pressure pulses induce nucleotide release in polarized MDCK cells

21 January 2018

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Crossref

https://api.crossref.org/works/10.1007%2FS00424-005-1431-5

Autosomal dominant polycystic kidney disease

21 January 2018

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12 December 2020

Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease

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12 December 2020

Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology.

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12 December 2020

Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene

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12 December 2020

Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins

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12 December 2020

Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins

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12 December 2020

Polycystins, calcium signaling, and human diseases.

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12 December 2020

The renal cell primary cilium functions as a flow sensor

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12 December 2020

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2

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12 December 2020

Genetic models of mechanotransduction: the nematode Caenorhabditis elegans

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12 December 2020

Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease

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12 December 2020

TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

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12 December 2020

Transport function of the naturally occurring pathogenic polycystin-2 mutant, R742X.

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12 December 2020

Bending the MDCK cell primary cilium increases intracellular calcium

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12 December 2020

New TRP channels in hearing and mechanosensation.

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12 December 2020

A flagellar polycystin-2 homolog required for male fertility in Drosophila

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12 December 2020

Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2

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12 December 2020

Polycystin-1L2 is a novel G-protein-binding protein

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12 December 2020

Polycystin-2 associates with the polycystin-1 homolog, suREJ3, and localizes to the acrosomal region of sea urchin spermatozoa

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12 December 2020

Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia

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12 December 2020

Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex

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12 December 2020

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

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12 December 2020

Polycystin-1 transforms the cAMP growth-responsive phenotype of M-1 cells

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12 December 2020

Polycystins: from mechanosensation to gene regulation

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12 December 2020

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

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12 December 2020

Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells

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12 December 2020

Identification and characterization of polycystin-2, the PKD2 gene product

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12 December 2020

The polycystic kidney disease 1 gene product modulates Wnt signaling

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12 December 2020

Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease

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12 December 2020

Hypotonicity induces TRPV4-mediated nociception in rat.

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12 December 2020

Molecular genetics and mechanism of autosomal dominant polycystic kidney disease

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12 December 2020

Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype

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12 December 2020

LNB-TM7, a group of seven-transmembrane proteins related to family-B G-protein-coupled receptors

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12 December 2020

The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro.

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12 December 2020

Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812.

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12 December 2020

Gating of the polycystin ion channel signaling complex in neurons and kidney cells

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12 December 2020

Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor

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12 December 2020

The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton

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12 December 2020

Molecular basis of mechanotransduction in living cells.

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12 December 2020

PKD2 cation channel is required for directional sperm movement and male fertility

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12 December 2020

Somatic inactivation of Pkd2 results in polycystic kidney disease

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12 December 2020

The ion channel polycystin-2 is required for left-right axis determination in mice

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12 December 2020

Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations.

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12 December 2020

Assembly and gating of TRPC channels in signalling microdomains

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12 December 2020

Aberrant polycystin-1 expression results in modification of activator protein-1 activity, whereas Wnt signaling remains unaffected

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12 December 2020

Global cytoskeletal control of mechanotransduction in kidney epithelial cells

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12 December 2020

New insights into ciliary function: kidney cysts and photoreceptors

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12 December 2020

Polycystin-2 associates with tropomyosin-1, an actin microfilament component

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12 December 2020

Polycystin-1 activates the calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway

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12 December 2020

Identification of two novel polycystic kidney disease-1-like genes in human and mouse genomes

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12 December 2020

Specific association of the gene product of PKD2 with the TRPC1 channel

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12 December 2020

TRPC1 forms the stretch-activated cation channel in vertebrate cells.

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12 December 2020

A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells

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12 December 2020

Interaction between RGS7 and polycystin

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12 December 2020

Polycystin-L is a calcium-regulated cation channel permeable to calcium ions

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12 December 2020

suREJ proteins: new signalling molecules in sea urchin spermatozoa.

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12 December 2020

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

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12 December 2020

Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel

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12 December 2020

Two populations of node monocilia initiate left-right asymmetry in the mouse

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12 December 2020

Polycystin-2 is an intracellular calcium release channel

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12 December 2020

Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist

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12 December 2020

Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation

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12 December 2020

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

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12 December 2020

Polycystin-1 interacts with intermediate filaments

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12 December 2020

A unified nomenclature for the superfamily of TRP cation channels.

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12 December 2020

Polycystin-1 activates and stabilizes the polycystin-2 channel.

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12 December 2020

Cell adhesion system and human cancer morphogenesis

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12 December 2020

A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans

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12 December 2020

High molecular mass egg fucose sulfate polymer is required for opening both Ca2+ channels involved in triggering the sea urchin sperm acrosome reaction

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12 December 2020

The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1.

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12 December 2020

Polycystic kidney disease--the ciliary connection

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12 December 2020

The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway

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12 December 2020

ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

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12 December 2020

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

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12 December 2020

Removal of the MDCK cell primary cilium abolishes flow sensing

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12 December 2020

Altered distribution and co-localization of polycystin-2 with polycystin-1 in MDCK cells after wounding stress

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12 December 2020

10.1007/S00424-005-1431-5

Identifiers

DOI

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12 August 2017

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PubMed ID

15889307