Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson's disease (Q36123393)

12 August 2017

Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson's disease (English)

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12 August 2017

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7

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4 June 2020

author name string

Won-Ho Shin

1

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4 June 2020

Min-Tae Jeon

2

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4 June 2020

Eunju Leem

3

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4 June 2020

So-Yoon Won

4

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4 June 2020

Kyoung Hoon Jeong

5

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4 June 2020

Sang-Joon Park

6

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4 June 2020

Sung Joong Lee

8

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4 June 2020

Byung Kwan Jin

9

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4 June 2020

Un Ju Jung

10

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4 June 2020

Sang Ryoung Kim

11

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4 June 2020

language of work or name

English

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publication date

6 October 2015

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12 August 2017

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4 June 2020

volume

5

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4 June 2020

page(s)

14764

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Creative Commons Attribution 4.0 International

4 June 2020

copyright license

start time

6 October 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/srep14764

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cites work

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Induction of GDNF and BDNF by hRheb(S16H) transduction of SNpc neurons: neuroprotective mechanisms of hRheb(S16H) in a model of Parkinson's disease.

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Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

2 October 2017

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Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease?

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AAV transduction of dopamine neurons with constitutively active Rheb protects from neurodegeneration and mediates axon regrowth.

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TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer's disease

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Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

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Endogenous toll-like receptor ligands and their biological significance

2 October 2017

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Neuroinflammation in Parkinson's disease: a target for neuroprotection?

2 October 2017

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The blood-brain barrier in health and chronic neurodegenerative disorders

2 October 2017

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Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion

2 October 2017

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Diagnosis and treatment of Parkinson disease: molecules to medicine

2 October 2017

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

2 October 2017

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Pathogen recognition and innate immunity

2 October 2017

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Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase

2 October 2017

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Inflammation, the complement system and the diseases of aging

2 October 2017

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Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism

2 October 2017

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Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

2 October 2017

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2 October 2017

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Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

2 October 2017

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

2 October 2017

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2 October 2017

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Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia.

2 October 2017

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2 July 2018

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Prothrombin kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation

2 July 2018

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Prothrombin mRNA is expressed by cells of the nervous system.

2 July 2018

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Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation.

2 July 2018

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Inhibition of thrombin-induced microglial activation and NADPH oxidase by minocycline protects dopaminergic neurons in the substantia nigra in vivo

23 September 2018

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Cultured astrocytes express toll-like receptors for bacterial products.

23 September 2018

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Thrombin-induced microglial activation produces degeneration of nigral dopaminergic neurons in vivo.

23 September 2018

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Broad expression of Toll-like receptors in the human central nervous system

23 September 2018

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Increased dopamine turnover after partial loss of dopaminergic neurons: compensation or toxicity?

23 September 2018

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Microglial activation mediates neurodegeneration related to oligodendroglial α-synucleinopathy: Implications for multiple system atrophy

23 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSREP14764

Agrin and microvascular damage in Alzheimer’s disease

21 January 2018

1 reference

12 December 2020

The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS

1 reference

12 December 2020

1 reference

12 December 2020

Blood coagulation factor Xa interacts with a linear sequence of the kringle 2 domain of prothrombin

1 reference

12 December 2020

Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: localization, expression and participation in neurodegenerative diseases

1 reference

12 December 2020

Expression of TLR4 and CD14 in the central nervous system (CNS) in a MPTP mouse model of Parkinson's-like disease

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP14764

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26440368%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

4 June 2020

0 references

1 reference

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4 June 2020

PubMed publication ID

26440368

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26440368%20AND%20SRC:MED&resulttype=core&format=json