Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis. (Q36121733)

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English	Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis.	scientific article

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7 February 2020

Promoter methylation of argininosuccinate synthetase-1 sensitises lymphomas to arginine deiminase treatment, autophagy and caspase-dependent apoptosis (English)

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7 February 2020

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Eleftheria Hatzimichael

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Alexandra Papoudou-Bai

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Tracey Mitchell

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B Delage

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P Luong

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L Maharaj

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C O'Riain

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N Syed

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T Crook

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S J Whittaker

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R Cerio

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J Gribben

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N Lemoine

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J Bomalaski

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C-F Li

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S Joel

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J Fitzgibbon

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L-T Chen

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P W Szlosarek

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publication date

5 July 2012

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Cell Death and Disease

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7 February 2020

3

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e342

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7 February 2020

Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells

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A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients

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Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer.

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2 October 2017

Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.

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L-arginine deprivation impairs Leishmania major-specific T-cell responses

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Large-scale profiling of archival lymph nodes reveals pervasive remodeling of the follicular lymphoma methylome

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Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis

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2 October 2017

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

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2 October 2017

In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion

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Regulation of immune responses by L-arginine metabolism

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2 October 2017

The Effects of Arginine Deficiency on Lymphoma Cells

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Effect of arginine deficiency on synthesis of DNA and immunoglobulin receptor of Burkitt lymphoma cells.

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Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma

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Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer.

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Citrulline can preserve proliferation and prevent the loss of CD3 zeta chain under conditions of low arginine

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23 September 2018

Arginine deiminase enhances dexamethasone-induced cytotoxicity in human T-lymphoblastic leukemia CCRF-CEM cells.

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Elevated gene expression of argininosuccinate synthetase in peripheral lymphocytes from systemic lupus erythematosus (SLE) patients

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12 December 2020

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The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes

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https://pubmed.ncbi.nlm.nih.gov/22764101

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10.1038/CDDIS.2012.83

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24 November 2022

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7 February 2020

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