Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis. (Q36100570)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22117694%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22117694%20AND%20SRC:MED&resulttype=core&format=json

amyotrophic lateral sclerosis

17 January 2020

main subject

0 references

D-Serine

1 reference

ChEBI release 2020-05-28

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22117694%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Steven Barger

6

1 reference

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17 January 2020

author name string

Misty Thompson

1

1 reference

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17 January 2020

John C Marecki

2

1 reference

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17 January 2020

Stephane Marinesco

3

1 reference

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17 January 2020

John C Roder

5

1 reference

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17 January 2020

John P Crow

7

1 reference

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17 January 2020

language of work or name

English

0 references

publication date

4 January 2012

1 reference

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Journal of Neurochemistry

17 January 2020

published in

1 reference

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17 January 2020

volume

120

1 reference

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17 January 2020

issue

4

1 reference

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17 January 2020

page(s)

598-610

1 reference

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Familial amyotrophic lateral sclerosis is associated with a mutation in D-amino acid oxidase

17 January 2020

cites work

1 reference

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Metabolism of the neuromodulator D-serine.

2 October 2017

1 reference

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Serine racemase deletion protects against cerebral ischemia and excitotoxicity

2 October 2017

1 reference

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Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model.

2 October 2017

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Glutamatergic regulation of serine racemase via reversal of PIP2 inhibition

2 October 2017

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Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior

2 October 2017

1 reference

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Serine racemase is predominantly localized in neurons in mouse brain

2 October 2017

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D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis

2 October 2017

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

2 October 2017

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Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

2 October 2017

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Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS

2 October 2017

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ALS: a disease of motor neurons and their nonneuronal neighbors

2 October 2017

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D-serine signalling in the brain: friend and foe.

2 October 2017

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Sensitive determination of D-amino acids in mammals and the effect of D-amino-acid oxidase activity on their amounts

2 October 2017

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Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine

2 October 2017

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Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression.

2 October 2017

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Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity

2 October 2017

1 reference

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Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide

2 October 2017

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Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis

2 October 2017

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Distribution and pharmacology of alanine–serine–cysteine transporter 1 (asc‐1) in rodent brain

2 October 2017

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Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis

2 October 2017

1 reference

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A new strategy to decrease N-methyl-D-aspartate (NMDA) receptor coactivation: inhibition of D-serine synthesis by converting serine racemase into an eliminase

2 October 2017

1 reference

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Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity

2 October 2017

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Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

2 October 2017

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Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

2 October 2017

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D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release

2 October 2017

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2 October 2017

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Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

2 October 2017

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Glycine decreases desensitization of N-methyl-D-aspartate (NMDA) receptors expressed in Xenopus oocytes and is required for NMDA responses.

2 October 2017

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Extracellular concentration of endogenous free D-serine in the rat brain as revealed by in vivo microdialysis

2 October 2017

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Manganese porphyrin given at symptom onset markedly extends survival of ALS mice

2 July 2018

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Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection

21 January 2018

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Levels of D-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice.

21 January 2018

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NMDA- and beta-amyloid1-42-induced neurotoxicity is attenuated in serine racemase knock-out mice.

21 January 2018

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Characterization of a yeast D-amino acid oxidase microbiosensor for D-serine detection in the central nervous system

21 January 2018

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Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity

21 January 2018

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Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice.

21 January 2018

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Glutamate-induced neuron death requires mitochondrial calcium uptake

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/22117694

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Specificity and kinetics of Rhodotorula gracilis D-amino acid oxidase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22117694

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Glycine and D-serine increase the affinity of N-methyl-D-aspartate sensitive glutamate binding sites in rat brain synaptic membranes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22117694

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1471-4159.2011.07601.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22117694%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22117694%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference