Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism (Q36099442)

12 August 2017

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title

Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism (English)

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12 August 2017

11

Jos H Beijnen

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12 August 2017

Antonius E van Herwaarden

1

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12 August 2017

Els Wagenaar

2

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12 August 2017

Cornelia M M van der Kruijssen

3

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12 August 2017

Robert A B van Waterschoot

4

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12 August 2017

Johan W Smit

5

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12 August 2017

Ji-Ying Song

6

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12 August 2017

Martin A van der Valk

7

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12 August 2017

Olaf van Tellingen

8

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12 August 2017

José W A van der Hoorn

9

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12 August 2017

Hilde Rosing

10

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12 August 2017

Alfred H Schinkel

12

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12 August 2017

language of work or name

English

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publication date

1 November 2007

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Journal of Clinical Investigation

12 August 2017

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12 August 2017

117

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12 August 2017

11

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12 August 2017

3583-3592

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Potential for improvement of docetaxel-based chemotherapy: a pharmacological review

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Drug metabolism and variability among patients in drug response

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Quantitative analysis of docetaxel in human plasma using liquid chromatography coupled with tandem mass spectrometry

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Genetic contribution to variable human CYP3A-mediated metabolism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Is the role of the small intestine in first-pass metabolism overemphasized?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Cytochrome P-450 3A4: regulation and role in drug metabolism

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Hepatic biotransformation of docetaxel (Taxotere) in vitro: involvement of the CYP3A subfamily in humans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Population pharmacokinetics/pharmacodynamics of docetaxel in phase II studies in patients with cancer.

2 October 2017

1 reference

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Corticosterone 6 beta-hydroxylase in A6 epithelia: a steroid-inducible cytochrome P-450.

2 July 2018

1 reference

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Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Association between the CYP3A5 genotype and blood pressure

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Megabase deletions of gene deserts result in viable mice

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

Hormonal regulation of the zonated expression of cytochrome P-450 3A in rat liver

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

No association of theCYP3A5*1allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045619

P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate

5 December 2018

1 reference

12 December 2020

Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver

1 reference

12 December 2020

Molecular and physical mechanisms of first-pass extraction

1 reference

12 December 2020

Intestinal and Hepatic Metabolic Activity of Five Cytochrome P450 Enzymes: Impact on Prediction of First-Pass Metabolism

1 reference

12 December 2020

The effect of an individual's cytochrome CYP3A4 activity on docetaxel clearance

1 reference

12 December 2020

Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes

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12 December 2020

Identifiers

DOI

10.1172/JCI33435

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12 August 2017

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12 August 2017

PubMed publication ID

17975676

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